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What is the primary purpose of sodium chloride in eye lotion?

  • To act as a preservative
  • To provide antibacterial properties
  • To enhance therapeutic efficacy
  • To dissolve and create a saline solution (correct)
  • What is a major consideration in the formulation of ear drops?

  • The packaging type of the drops
  • The selection of a suitable vehicle (correct)
  • The color of the solution
  • The temperature of the solution
  • Which vehicle is NOT commonly used in ear drop formulations?

  • Oily liquid (correct)
  • Water
  • Glycerin
  • Propylene glycol
  • What is the role of glycerin in sodium bicarbonate ear drops?

    <p>To provide softening capacity (A)</p> Signup and view all the answers

    Why are nasal drops required to be isotonic with nasal secretions?

    <p>To prevent irritation (D)</p> Signup and view all the answers

    What pH level is generally ideal for nasal drops to mimic nasal secretions?

    <p>6.8 (D)</p> Signup and view all the answers

    What can be a consequence of using oily vehicles in nasal formulations over time?

    <p>Development of lipoidal pneumonia (C)</p> Signup and view all the answers

    Which preservative is mentioned as commonly used in ear drop formulations?

    <p>Chlorobutanol (A)</p> Signup and view all the answers

    What is the purpose of flavoring agents in mouthwashes?

    <p>To reduce unpleasant taste and odor (D)</p> Signup and view all the answers

    Which ingredient is NOT typically included in a throat paint formulation?

    <p>Methyl salicylate (A)</p> Signup and view all the answers

    For which condition are throat paints particularly used?

    <p>Pharyngitis (B)</p> Signup and view all the answers

    What is a common drawback of throat paints?

    <p>Increased salivary secretion (C)</p> Signup and view all the answers

    Which labeling requirement is essential for throat paints?

    <p>For external use only (C)</p> Signup and view all the answers

    What type of container should throat paints be stored in?

    <p>Coloured fluted airtight containers (D)</p> Signup and view all the answers

    What is the main reason for adding glycerin to throat paints?

    <p>To prolong contact with the mucous membrane (A)</p> Signup and view all the answers

    Which of the following is NOT a component typically cited for mouthwash formulations?

    <p>Astringents (A)</p> Signup and view all the answers

    What is the primary advantage of a cylindrical percolator in drug extraction?

    <p>It minimizes the expenditure of menstruum while providing complete extraction. (C)</p> Signup and view all the answers

    Which type of percolator is best suited for drugs that swell significantly during maceration?

    <p>Funnel shaped percolator (D)</p> Signup and view all the answers

    What is the main component of fluidextracts that contributes to their potency?

    <p>Alcohol (A)</p> Signup and view all the answers

    What factor makes many fluidextracts unsuitable for self-administration?

    <p>They are too potent or unpalatable. (D)</p> Signup and view all the answers

    How are extracts primarily obtained from drugs?

    <p>By employing percolation and evaporation of solvents. (D)</p> Signup and view all the answers

    What is the typical potency range of extracts compared to crude drugs?

    <p>They are two to six times more potent. (C)</p> Signup and view all the answers

    What is the purpose of reducing the volume of percolates by distillation?

    <p>To protect against thermal decomposition of active substances. (D)</p> Signup and view all the answers

    What role do flavoring or sweetening agents play in fluidextracts?

    <p>They make the fluidextracts more palatable. (C)</p> Signup and view all the answers

    What is the correct formula used to calculate the amount of concentrated HCl required for preparing diluted HCl?

    <p>$ rac{ ext{percentage strength of concentrated acid X specific gravity of concentrated acid}}{ ext{percentage strength of diluted acid X volume of diluted acid to be prepared}} = ext{volume of concentrated acid to use}$ (B)</p> Signup and view all the answers

    How much concentrated HCl is needed to prepare 100 mL of diluted hydrochloric acid with a 10% strength from a concentrated acid with a specific gravity of 1.17?

    <p>23.41 ml (A)</p> Signup and view all the answers

    In drug extraction, what term is used to refer to the exhausted plant residue after extraction?

    <p>Marc (C)</p> Signup and view all the answers

    Why is water commonly used as a solvent in drug extraction?

    <p>It has good solvent action and is readily available. (B)</p> Signup and view all the answers

    What does the term 'menstruum' refer to in the context of drug extraction?

    <p>The solvent or solvent mixture used for extraction. (D)</p> Signup and view all the answers

    What is NOT a type of application for acetic acid mentioned?

    <p>Used as a 5% solution in wound care (A)</p> Signup and view all the answers

    Which of the following statements about the composition of crude drugs is correct?

    <p>Crude drugs may contain active and inactive compounds. (B)</p> Signup and view all the answers

    What characteristic is important when selecting a solvent for drug extraction?

    <p>The solvent should dissolve maximum active constituents with minimal undesirable constituents. (A)</p> Signup and view all the answers

    What is a characteristic of powdered extracts compared to pilular extracts?

    <p>Are intended to be dry with all menstruum removed (D)</p> Signup and view all the answers

    What is the primary purpose of maceration in the extraction process?

    <p>To dissolve the soluble constituents of a drug in a menstruum (A)</p> Signup and view all the answers

    Which extraction method is used to obtain pharmaceutical resins from plants?

    <p>Percolation with a solvent (B)</p> Signup and view all the answers

    During maceration, how is the comminuted drug treated to facilitate extraction?

    <p>It is agitated frequently in a stoppered container (D)</p> Signup and view all the answers

    Which of the following statements is true regarding the properties of resins?

    <p>Resins are combustible and non-conductive (B)</p> Signup and view all the answers

    What happens to the soluble constituents during the maceration extraction when using a porous cloth bag?

    <p>They tend to settle at the bottom of the container (D)</p> Signup and view all the answers

    What forms the basis for distinguishing pilular and powdered extracts?

    <p>The amount of menstruum remaining in the preparation (B)</p> Signup and view all the answers

    What temperature range is usually maintained during maceration?

    <p>15 °C – 20 °C (B)</p> Signup and view all the answers

    What are resins primarily composed of?

    <p>Oxidized terpenes and carboxylic acids (A)</p> Signup and view all the answers

    What is the main characteristic of the percolation process?

    <p>The menstruum is passed slowly through a column of drug (C)</p> Signup and view all the answers

    In which dosage form is pilular extract preferred?

    <p>Ointments or pastes (A)</p> Signup and view all the answers

    What happens to resins when heated?

    <p>They soften and eventually melt (C)</p> Signup and view all the answers

    In percolation, how does the menstruum flow through the drug column?

    <p>It flows downward due to gravity and the weight of the liquid (C)</p> Signup and view all the answers

    What is typically referred to as the collected extractive in the percolation process?

    <p>The percolate (B)</p> Signup and view all the answers

    Which statement about natural resins is correct?

    <p>They are solid or semisolid exudations from plants or certain insects (B)</p> Signup and view all the answers

    Which type of drugs can maceration be most effectively utilized for?

    <p>Drugs containing little or no cellular material (D)</p> Signup and view all the answers

    Flashcards

    Mouthwash Purpose

    Mouthwash is used therapeutically to reduce plaque, gingivitis, dental caries, and stomatitis, or cosmetically to reduce bad breath.

    Mouthwash Flavoring

    Mouthwashes use peppermint, spearmint, cinnamon, wintergreen, menthol, and methyl salicylate oils for pleasant taste and odor, masking bad taste and odor.

    Mouthwash Application

    Mouthwash is diluted before use, and it is for external use only; avoid swallowing large quantities.

    Throat Paint Composition

    Throat paints are viscous liquids with medicaments for treating throat/mouth infections.

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    Throat Paint Viscosity

    High glycerin content makes throat paints viscous to keep the medicine on the affected area longer.

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    Throat Paint Application

    Apply throat paint directly to the affected area using a brush or cotton plug.

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    Throat Paint Storage

    Throat paints are stored in colored, airtight containers.

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    Throat Paint Benefits

    Throat paints are helpful in treating pharyngitis, laryngitis, and follicular tonsillitis.

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    Ear Drops Composition

    Solutions of drugs in water, glycerol, propylene glycol, or alcohol/water mixtures for local ear use.

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    Ear Drop Vehicle Choice

    The liquid base for ear drops should mix well with earwax and allow drug contact with ear tissue.

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    Nasal Drops and Isotonicity

    Nasal drops solutions should have similar salt content (isotonic) to nasal secretions for comfort.

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    Nasal Drops pH

    Nasal drops need a pH of 6.8 to match the nasal mucosa's buffering capacity, which is low.

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    Oily Vehicle in Nasal Drops

    Oils in nasal drops hinder cilia movement (tiny hairs) in the nose.

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    Normal Saline Solution

    A solution of sodium chloride in purified water used as an eye wash and in other medical applications.

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    Sodium Bicarbonate Ear Drops

    Ear drops containing sodium bicarbonate, glycerin, and purified water, commonly used for pain relief and cleaning ear wax.

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    Sodium Chloride Eye Lotion

    An eye lotion containing sodium chloride and purified water; a simple and effective eye rinse.

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    Diluted HCl calculation

    A formula to determine the concentrated HCl required for a specific volume of diluted HCl.

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    100 mL diluted HCl

    Example calculation for preparing 100 mL of diluted HCl from concentrated HCl.

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    Extraction method

    Process to extract desired constituents from crude drugs using solvents.

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    Crude drug

    Plant or animal drug minimally processed, cleaned, and dried.

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    Menstruum

    Solvent or solvent mixture used in drug extraction.

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    Marc

    Plant residue after extraction; exhausted of active constituents.

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    Solvent Selection

    Choosing solvents based on desired constituent solubility and minimizing unwanted constituent solubility.

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    Water in Extraction

    Water can be used in drug extraction, often in conjunction with other solvents, due to availability, cost-effectiveness, and ability to dissolve plant constituents.

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    Maceration

    A process where a drug is soaked in a liquid (menstruum) to soften its cellular structure and dissolve its soluble components.

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    Maceration Methods

    Maceration can be done by repeatedly agitating the drug in the menstruum or by placing the drug in a porous bag and suspending it in the menstruum.

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    Percolation

    A process where a drug is extracted by slowly passing a solvent through a column of the drug.

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    Percolator

    A specialized apparatus used for percolation, where the drug is packed and the extracted liquid (percolate) is collected.

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    Downward Flow in Percolation

    The solvent in percolation usually flows downwards through the drug column due to gravity and the weight of the liquid.

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    Specialized Percolation

    Some advanced percolators use air pressure to enhance the solvent flow through the drug column.

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    Cylindrical Percolator

    A tall, narrow percolator ideal for complete extraction of drugs using minimal solvent. The narrow design ensures repeated exposure of drug particles to the solvent.

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    Funnel-Shaped Percolator

    A wide-mouthed percolator suitable for drugs that expand significantly during maceration. The wide top allows swelling without overcrowding, minimizing breakage.

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    Fluidextracts

    Liquid preparations from plants made by percolation, using alcohol as solvent and preservative. Each milliliter contains the therapeutic constituents of 1 gram of the standard drug.

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    Why are fluidextracts rarely used directly?

    Many fluidextracts are considered too potent for safe self-administration and are often bitter-tasting or unpalatable.

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    Extracts

    Concentrated plant or animal preparations obtained by removing active constituents with solvents, evaporating the solvent, and adjusting to prescribed standards. They are typically more potent than the crude drug.

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    Percolation in Extract Production

    Percolation is commonly used to remove active constituents from the drug during extract manufacturing. The resulting percolate is often concentrated by distillation under reduced pressure to preserve drug integrity.

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    Extract Types

    The final consistency of an extract (solid, semi-solid, or liquid) depends on the extent of solvent removal.

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    Why is distillation used in extract production?

    Distillation under reduced pressure is used to concentrate extracts while minimizing heat exposure, protecting the drug substances from degradation.

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    What are extracts?

    Extracts are concentrated preparations made by dissolving active ingredients from plants or animals in a suitable solvent. They come in different forms: semiliquid, pilular, and powdered.

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    Pilular extract: form and advantage?

    Pilular extracts are solid and pliable, resembling a pill. They are preferred when making ointments or pastes because their consistency allows for easy mixing.

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    Powdered extract: form and advantage?

    Powdered extracts are completely dry and consist of finely ground active ingredients. They are suitable for making powders, capsules, and tablets due to their consistency.

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    What are resins?

    Resins are complex mixtures of essential oils, terpene derivatives, and acids, usually found as exudations from trees.

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    How are resins formed?

    Resins are created as waste products of plant metabolism, often accumulating in specialized cavities or ducts within the plant.

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    What are the properties of resins?

    Resins are typically solid or semi-solid, insoluble in water but soluble in organic solvents. They are often transparent, hard, and combustible.

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    How are pharmaceutical resins obtained?

    Resins are obtained from plants and animals using two main methods: extraction with alcohol and precipitation with water, or distillation for oil separation.

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    Example of a resin: Podophyllum Resin?

    Podophyllum Resin is obtained by extracting the active components from dried rhizome and roots of the Podophyllum plant.

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    Study Notes

    Pharmaceutical Technology I: Topical Solutions and Extracts

    • Topical solutions and extracts, administered orally, are linctuses.
    • Linctuses are viscous liquid preparations used to relieve coughs.
    • Linctuses typically contain a high concentration of sucrose and sometimes other sweetening agents.
    • Linctuses are taken in 5mL amounts, should be taken slowly and not diluted beforehand.
    • Simple syrup is a common vehicle used in linctuses.
    • Syrup tolu is preferred in certain cases due to its aromatic odor and flavor, and also a mild expectorant action.
    • Adjuvants include chemical stabilizers, coloring agents (coal tar dyes), flavoring agents (lemon syrup, black current syrup, oxymel) and preservatives.
    • Linctuses do not usually have significant side effects like headache, stomach upset or diarrhea, however, overdose may cause these issues.

    Liquid Dosage Form Used in Oral Cavity: Sprays

    • Sprays are aqueous or oleaginous solutions or finely divided solids.
    • They are applied topically, most frequently to the nasopharyngeal tract or skin.
    • Commonly used sprays are intranasal for relieving nasal congestion, treating infections, and containing antihistamines, sympathomimetic agents, and antibiotics.
    • Insulin and glucagon can potentially be administered via nasal spray. This offers faster symptom relief compared to intravenous administration.
    • Sprays for sunburn and heat burns contain local anesthetics, antiseptics, skin protectants, and antipruritics .
    • Plastic spray bottles are commonly used for nasal decongestant sprays and cosmetics like body deodorants.
    • One-way pump sprays are designed to deliver medicine directly into the nose, and help prevent contamination of the bottle.

    Liquid Dosage Form Used in Oral Cavity: Mouthwashes and Gargles

    • Mouthwashes and gargles are aqueous solutions, often concentrated, containing active ingredients and excipients.
    • Mouthwashes enhance oral hygiene and can address conditions like plaque, gingivitis, dental caries, and stomatitis.
    • Flavors like peppermint oil, spearmint oil, cinnamon oil, wintergreen oil, menthol, and methyl salicylate are commonly used.
    • Mouthwashes are dispensed in white fluted bottles, clearly labeled with dilution instructions and warnings about not swallowing.

    Liquid Dosage Form Used in Oral Cavity: Throat Paints

    • Throat paints are viscous, liquid preparations with one or more medicaments, commonly containing high glycerin content, for throat and mouth infections.
    • Viscous liquids meant to have sustained contact with the throat lining and provide prolonged drug effect and are used for pharyngitis, laryngitis, and follicular tonsillitis.
    • Throat paints are often used for local conditions and applied directly with a brush or cotton swab to the affected area.
    • The formulation includes viscous vehicles, flavoring agents, coloring agents, and sweetening agents.
    • Medicaments like antiseptics, astringents, and anti-infectives may also be included.

    Liquid Dosage Form Used in Oral Cavity: Eye Drops

    • Eye drops are sterile aqueous or oily solutions or suspensions used for instillation on the eyeball or within the conjunctival sac for local effects.
    • Eye drops require sterility, isotonicity with lachrymal secretions, neutral pH, and freedom from foreign particles.
    • The preparation process for eye drops includes sterile preparation of vehicles, dissolving the specific medicaments, clarifying the resultant mixtures, and appropriate sterilization to eliminate particulate matter.
    • Sterilization methods can include autoclaving, heating, and filtration through a membrane filter.

    Liquid Dosage Form Used in Oral Cavity: Ear Drops

    • Ear drops are simple solutions in water, glycerol, propylene glycol, or alcohol/water mixtures for local use including antibiotics, antiseptics, and wax softeners.
    • Used for cleaning ears, softening wax, and treating mild infections, however, may inconvenience patients as they need to lie down or tilt their heads.
    • Vehicles such as anhydrous glycerin and propylene glycols are popularly used.
    • The solutions, after preparation, would be placed in a suitable container and the label "For external use only" would be displayed.

    Liquid Dosage Form Used in Oral Cavity: Douches

    • Douches are aqueous solutions used as cleansing and antiseptic agents for various cavities in the body, typically applied through the use of bulb syringes.
    • Common ingredients in douches include cleansing agents (e.g., sodium chloride, sodium bicarbonate), antiseptics (e.g., chlorhexidine), and astringents (e.g., tannic acid, zinc sulfate).
    • Douches are commonly used for nasal, pharyngeal, vaginal and eye cleaning.
    • Eye, pharyngeal, nasal, and vaginal douches are commonly used for various purposes based on the specific region of the body that needs cleansing or treatment.

    Liquid Dosage Form Used in Oral Cavity: Enemas

    • Enemas are aqueous or oily solutions, emulsions, or suspensions used for rectal administration for diagnostic or therapeutic reasons including cleansing.
    • Enemas can be categorized into cleansing, carminative, retention, lubricating, or medicated enemas based on their intended use.
    • Administration of enemas requires the help of trained professionals and proper warming of the solution to body temperature.
    • The volume of the enema administered is tailored based on the patient's age and health condition.

    Intermediate Products: Aromatic Waters

    • Aromatic waters are clear, aqueous solutions saturated with volatile or aromatic substances.
    • Aromatic waters can include orange flower, peppermint, rose, anise, spearmint, and wintergreen oil, amongst others.
    • They are primarily used in perfumery and flavoring, rather than as standalone therapeutic agents.

    Intermediate Products: Concentrated Acids:

    • Dilute acids are prepared by diluting concentrated acids with purified water.
    • The strength of the dilute acid is expressed as %w/v.
    • The strength of concentrated acid is expressed in %w/w.
    • HCl (hydrochloric acid) is an example; its concentrations are usually above 60% w/v.

    Intermediate Products: Spirits

    • Spirits are alcoholic or hydroalcoholic solutions of volatile substances, with concentrations usually above 60%.
    • Spirits are used as flavoring agents and medicinally for the therapeutic value of the aromatic solvent.
    • They may be prepared by simple solution, solution by maceration, or distillation. Common examples may include aromatic ammonia spirit, camphor spirit, compound orange spirit, and peppermint spirit.

    Extraction Methods for Preparing Solutions

    • Extraction procedures are important to isolate desired chemical components from crude materials.
    • Maceration is a technique where the drug is immersed (soaked) in a solvent until the desired constituents are dissolved.
    • Percolation is a method where a suitable solvent is passed through a column of the drug to extract the desired constituents.
    • The choice of method depends on factors like the crude drug's properties, the desired constituents, and required quality of the solution.

    Example Preparations Prepared by Extraction Processes: Fluidextracts

    • Fluidextracts are liquid preparations containing a concentrated amount of active components for each milligram of the drug source.
    • They're mainly utilized as sources for medicinal extracts for therapeutic application or as components of other drug preparations like syrups.

    Example Preparations Prepared by Extraction Processes: Extracts

    • Extracts are concentrated preparations of plant or animal substances, obtained by removing the active components using an appropriate solvent and adjusting the resultant dry material.
    • Some extracts are prepared by first using a maceration method, and then percolating to improve the yield of solvent extraction.
    • The process involves extraction of active contents and reduction in volume using distillation under heat or reduced pressure for preservation purposes.
    • The extent of solvent removal determines the physical characteristics of the final extract and can be liquid(syrupy), solid, or powdered formulations.

    Resins and Oleoresins

    • Resins are amorphous or semi-solid exudates from trees or from insects feeding on the trees.
    • Resins are characterized by their lack of definite shapes, and chemically contain organic acids, alcohols, and neutral resins.
    • Oleoresins are mixtures of resins and volatile oils, often used as a starting material for further processing.
    • Oleoresins can be solid or liquid, depending on the amount of volatile oil they contain.

    Glycerits

    • Glycerits are preparations that contain at least 50% glycerin by weight and a medicinal agent.
    • Glycerins are usually prepared as solutions of medicinal agents in glycerin, with or without other additives like preservatives and flavors.
    • The presence of glycerin in preparations helps maintain stability and increase viscosity. Glycerins are used as topical or for local applications.

    Colloidal Dispersions

    • Colloidal dispersions are mixtures of very small particles dispersed in a medium, with the particles' size between 1 nm and 0.5 µm.
    • Colloidal systems can be either lyophilic (attracted to the solvent) or lyophobic (not attracted to the solvent).
    • Lyophilic colloids are often used for stabilization and include organic macromolecules that disperse easily in a liquid.
    • Lyophobic colloids are inorganic materials that require special stabilization techniques prior to use.

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