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After saving the notes, what is not necessary for users?

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What is the goal of the notes according to the message from the team?

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What is NOT permitted under the license agreement of the notes?

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What is the primary function of the fibrous pericardium?

<p>Anchors the heart to surrounding structures (A)</p> Signup and view all the answers

Which layer of the heart wall is responsible for the contraction of the heart?

<p>Myocardium (C)</p> Signup and view all the answers

What is the role of the endocardium in the heart?

<p>Lines the chambers and prevents blood clotting (D)</p> Signup and view all the answers

Where is the middle mediastinum located?

<p>In the inferior mediastinum behind the sternum (C)</p> Signup and view all the answers

What structure surrounds the heart and contains serous fluid?

<p>Pericardium (A)</p> Signup and view all the answers

Which part of the fibrous skeleton of the heart serves to electrically isolate the heart's chambers?

<p>Septums (B)</p> Signup and view all the answers

Which of the following correctly describes the serous pericardium?

<p>It has parietal and visceral layers (A)</p> Signup and view all the answers

What is the primary material that reinforces the myocardium and supports the heart's structure?

<p>Connective tissue fibers (D)</p> Signup and view all the answers

What is the primary effect of the parasympathetic nervous system on heart rate?

<p>Decreases heart rate through acetylcholine release (A)</p> Signup and view all the answers

How does sympathetic stimulation affect the heart muscle cells?

<p>Enhances contractile force due to increased calcium influx (A)</p> Signup and view all the answers

What does a typical 12-lead ECG measure?

<p>A combination of electrical signals over time (A)</p> Signup and view all the answers

Which of the following statements about the sympathetic nervous system is true?

<p>It raises heart rate and increases calcium permeability in heart tissues (D)</p> Signup and view all the answers

What initiates the cyclic AMP pathway in the sympathetic nervous system?

<p>Binding of norepinephrine to beta 1 receptors (D)</p> Signup and view all the answers

What effect does the parasympathetic nervous system have on potassium permeability in the heart?

<p>Increases potassium efflux, hyperpolarizing the cell (C)</p> Signup and view all the answers

Which of the following correctly describes the role of acetylcholine in heart function?

<p>It helps to hyperpolarize the SA and AV nodes, slowing the heart rate (D)</p> Signup and view all the answers

How does increased sodium permeability affect the heart rate during sympathetic stimulation?

<p>Increases depolarization speed, raising heart rate (D)</p> Signup and view all the answers

What structure allows action potentials to move from cell to cell in the heart?

<p>Gap junctions (C)</p> Signup and view all the answers

What is the correct sequence of the heart's conduction system?

<p>SA Node → AV Node → Bundle of His → R &amp; L Bundle Branches → Purkinje Fibres (D)</p> Signup and view all the answers

Which ions are primarily involved in the spontaneous depolarization of the SA and AV node cells?

<p>Na+ and Ca2+ (A)</p> Signup and view all the answers

During repolarization of pacemaker cells, which ion channels primarily open?

<p>K+ channels (D)</p> Signup and view all the answers

What type of action potentials do contractile cardiac cells generate?

<p>Fast Non-Pacemaker Type (B)</p> Signup and view all the answers

What initiates the massive influx of Na+ ions in contractile cardiac cells?

<p>Threshold reached (D)</p> Signup and view all the answers

What causes the plateau phase in the action potential of contractile cardiac cells?

<p>Inactivation of Na+ channels (C)</p> Signup and view all the answers

Which factor primarily determines the firing frequency of SA and AV node cells?

<p>Movement of Na+ ions (D)</p> Signup and view all the answers

What is the role of the Na/K-ATPase during repolarization?

<p>It removes excess Na+ and replaces deficit K+ in the cell. (B)</p> Signup and view all the answers

What is the approximate duration of the Absolute Refractory Period in cardiac muscle?

<p>200ms (D)</p> Signup and view all the answers

What happens to K+ channels during repolarization of cardiac muscle cells?

<p>They open, accelerating the process of repolarization. (B)</p> Signup and view all the answers

Which structure sets the pace for the heart's contractions?

<p>The SinoAtrial (SA) Node (C)</p> Signup and view all the answers

What effect does the Parasympathetic Nervous System have on heart rate?

<p>It lowers heart rate to maintain a normal resting rate. (B)</p> Signup and view all the answers

Where is the Atrioventricular (AV) Node located?

<p>Inferior portion of the InterAtrial Septum. (C)</p> Signup and view all the answers

What indicates that the SA Node is functioning properly?

<p>Presence of the P-Wave (C)</p> Signup and view all the answers

How does the influx of Ca+ ions contribute to muscle contraction in cardiac muscle cells?

<p>By facilitating muscular contraction through increased myoplasmic Ca+ levels. (C)</p> Signup and view all the answers

What does the PR-Segment reflect in the ECG?

<p>Delay between the SA Node and AV Node (A)</p> Signup and view all the answers

What occurs during the Relative Refractory Period?

<p>The muscle can respond to stronger-than-normal stimuli. (D)</p> Signup and view all the answers

What causes the Q-Wave to show a biphasic trace?

<p>Signal cancellation by atrial repolarization (D)</p> Signup and view all the answers

Which part of the ECG waveform corresponds to ventricular depolarization?

<p>R-Wave (C)</p> Signup and view all the answers

What occurs during the ST-Segment of the ECG?

<p>Ventricular contraction (B)</p> Signup and view all the answers

Which wave in the ECG indicates repolarization of the ventricles?

<p>T-Wave (C)</p> Signup and view all the answers

Which wave is associated with depolarization of the interventricular septum?

<p>Q-Wave (A)</p> Signup and view all the answers

In which situation is a negative deflection observed in the ECG?

<p>When depolarization moves away from a positive electrode (C)</p> Signup and view all the answers

Flashcards

Parasympathetic NS effect on heart rate

Slows the heart rate by increasing potassium permeability, hyperpolarizing the cells, and lengthening the time to reach the threshold for firing.

Sympathetic NS effect on heart rate

Increases heart rate by increasing sodium and calcium permeability, accelerating the membrane's drift toward threshold.

Acetylcholine

Neurotransmitter released by the parasympathetic nervous system that slows heart rate.

Noradrenaline (Norepinephrine)

Neurotransmitter released by the sympathetic nervous system that increases heart rate and contractility.

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ECG (Electrocardiogram)

A recording of all action potentials from the heart's nodal and contractile cells at a given time.

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ECG Lead

A combination of electrodes that measures electrical signals along a line in the body.

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Hyperpolarization

An increase in the negativity of the inside of a cell's membrane, making the cell less likely to fire an action potential.

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Action Potential

A rapid change in the electrical potential across the membrane of a neuron or muscle cell, essential for signaling.

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Medical Student Notes

Are study materials for medical, pre-med, and PA students, focused on high-yield concepts for exams.

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Final Edition

The last version of the study notes.

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Download and Saving

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Sharing Prohibited

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Simultaneous Devices

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Offline Access

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File Transfer

Method to move files from one device to another without re-downloading.

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Download Allowance

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Middle Mediastinum Location

The middle mediastinum is located in the inferior mediastinum, extending from the 2nd rib to the 5th intercostal space, anterior to the vertebrae, posterior to the sternum, and flanked by the lungs. It rests on the diaphragm.

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Middle Mediastinum Position

Two-thirds of the middle mediastinum's mass is located to the left of the midsternal line.

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Pericardium Function

The pericardium is a protective sac that surrounds the heart, containing lubricating fluid to reduce friction. It anchors the heart and prevents overfilling, ensuring effective pumping.

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Fibrous Pericardium

The outer layer of the pericardium, made of tough connective tissue, protects the heart, anchors it, and prevents overfilling.

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Serous Pericardium

The inner layer of the pericardium, composed of two continuous layers: Parietal layer lining the fibrous pericardium and Visceral layer (Epicardium) lining the heart.

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Epicardium

The outer layer of the heart, also known as the visceral layer of the serous pericardium.

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Myocardium

The muscular layer of the heart responsible for contraction and heart pumping.

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Endocardium Function

The inner lining of the heart chambers, composed of endothelial cells, prevents blood clotting and acts as a barrier between the myocardium and blood.

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Gap Junctions

Special connections between cardiac muscle cells that allow action potentials to travel directly from one cell to another.

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Intercalated Discs

Specialized junctions that hold cardiac muscle cells together, providing structural support and allowing for synchronized contraction.

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SA Node

The 'pacemaker' of the heart, naturally generating electrical impulses that regulate the heart rate.

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AV Node

A relay station for electrical signals, delaying the impulse before passing it on to ventricles, allowing for proper chamber filling.

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Prepotential

The gradual depolarization of the membrane potential in SA/AV node cells, leading to an action potential.

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Contractile Cardiac Cells

Muscle cells of the heart that contract in response to electrical signals, primarily responsible for pumping blood.

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Plateau Phase

A period where the membrane potential remains relatively stable, allowing for prolonged contraction in cardiac muscle cells.

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Hierarchy of Cardiac Control

The SA node is the primary pacemaker, but other nodal cells can take over if the SA node fails.

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Calcium-induced Calcium Release (CICR)

A process where the initial influx of calcium into a muscle cell triggers the release of even more calcium from internal stores, amplifying the signal and leading to muscle contraction.

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Na+/K+ Pump

An active transport protein in the cell membrane that uses energy to pump sodium ions out of the cell and potassium ions into the cell, restoring ion balance after an action potential.

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Na+/Ca+ Exchanger

A protein that exchanges sodium ions for calcium ions across the cell membrane, removing excess calcium from the cell after a contraction.

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Relative Refractory Period

A period of time after the absolute refractory period where a stronger-than-normal stimulus can trigger a new action potential. This allows for fine-tuning of heart rate.

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P-Wave

Represents the depolarization of the atria, indicating the SA node is functioning properly.

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PR-Segment

Represents the delay between the SA node and AV node, allowing for atrial contraction.

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QRS Complex

Represents the depolarization of the ventricles.

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ST-Segment

Represents the period of ventricular contraction.

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T-Wave

Represents the repolarization of the ventricles.

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Positive Deflections

Occurs when the depolarization wavefront moves towards the positive electrode.

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Negative Deflections

Occurs when the depolarization wavefront moves away from the positive electrode.

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Study Notes

Cardiovascular System Final Edition Notes

  • This document is a pre-summarized, ready-to-study, high-yield set of notes on anatomy, physiology, and pathology of the cardiovascular system.
  • The book is 201 pages in length.
  • It provides open-source images and/or attributions where possible.
  • Notes are for a time-poor student of medicine, pre-med, USMLE, or PA students.

Using the Notes

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  • A download allowance is allocated per order, extensions may be required.
  • The user may use the discount code "TAKE20OFF" for 20% off future purchases.
  • Instructions for upgrading to a bundle deal with a 80% discount are available online.

Table of Contents

  • Anatomy & Physiology Notes:
    • Anatomy of the heart
    • Electrophysiology of the heart
    • ECG Physiology
    • Mechanical events of the cardiac cycle
    • Cardiodynamics
    • Haemodynamics
    • Blood pressure physiology
    • Anatomy & physiology of blood vessels
    • Physiology of hypertension
    • Physiology of shock
    • Physiology of myocardial ischaemia / ischaemia
    • Effects of aging on the heart
  • Pathology Notes:
    • Congenital heart defects
    • Aneurysms & Dissections
    • Arrhythmias
    • Dyslipidaemia
    • Atherosclerosis
    • Drug classes for treating arrhythmias
    • Ischemic heart disease
    • Acute cardiogenic pulmonary oedema
    • Heart failure
    • Pathologies of “Heart Muscle Diseases”
    • Pathology of hypertension
    • Pathology of shock
    • DVT & PE
    • Carcinoid heart disease
    • Infective & non-infective endocarditis
    • Lymphangitis
    • Myocarditis – viral & toxic
    • Pericarditis
    • Pericardial effusion
    • Acute arterial occlusion (“critical limb ischaemia”)
    • Peripheral vascular disease
    • Varicose veins
    • Chronic skin ulcers
    • Tumours of vessels
    • Important vasculitis
    • Kaposi sarcoma
    • Buerger's Disease ("thromboangiitis obliterans")

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