Cushing's Syndrome and Hypertension in Semester 5
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Questions and Answers

What is the blood pressure range that is considered a 'silent killer'?

  • 130–139/85-89 mmHg (correct)
  • 120–129/80-84 mmHg
  • <120/80 mmHg
  • >140/90 mmHg

    • What is the first step in finding the source of excess cortisol production in Cushing's Syndrome?

  • Check for adrenal lesions
  • Measure the 8am ACTH levels
  • Perform an overnight low dose dexamethasone suppression test (correct)
  • Conduct a hypothalamus function test

    • What is the typical ACTH level in ectopic ACTH production?

  • Elevated
  • Undetectable
  • Normal or slightly elevated
  • Highly elevated (correct)

    • What is the approximate surgical cure rate for Cushing's Disease?

    <p>65-90%</p> Signup and view all the answers

    What is the percentage of Cushing's Disease cases caused by pituitary adenoma?

    <p>80-85%</p> Signup and view all the answers

    Which of the following medications can cause analytical interference with chromogranin A?

    <p>Labetalol</p> Signup and view all the answers

    What is the primary mechanism of action of mineralocorticoids like aldosterone?

    <p>Activation of the epithelial sodium channel</p> Signup and view all the answers

    Which of the following is NOT a secondary cause of hypertension with an endocrine origin?

    <p>Hypothyroidism</p> Signup and view all the answers

    What is the purpose of measuring 24-hour urine cortisol levels?

    <p>To diagnose Cushing's syndrome</p> Signup and view all the answers

    According to the Seventh Report of the Joint National Committee, what is the primary goal of hypertension treatment?

    <p>Reducing blood pressure to normal levels</p> Signup and view all the answers

    Which of the following is NOT a characteristic of Apparent Mineralocorticoid Excess?

    <p>Increased aldosterone</p> Signup and view all the answers

    What is the primary effect of AT II on the distal renal tubules?

    <p>Stimulates sodium reabsorption</p> Signup and view all the answers

    Which of the following tests is used to diagnose ectopic ACTH production?

    <p>CRH stimulation test</p> Signup and view all the answers

    What is the primary effect of Amiloride on the body?

    <p>Blocks the epithelial sodium channel (ENaC)</p> Signup and view all the answers

    What is the characteristic of a patient with a defect in 11β-hydroxysteroid dehydrogenase type II (11HSD type II)?

    <p>Hypertension and hypokalemia</p> Signup and view all the answers

    Which of the following is a characteristic of Phaeochromocytoma?

    <p>Paroxysmal or sustained hypertension</p> Signup and view all the answers

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