18 Questions
Which factor does NOT influence the crystal habit of a substance during crystallization?
Pressure applied
Which physical property of crystals can significantly affect the production of dosage forms?
Crystal shape
What term is used to describe a unit cell with a single atom in the centre?
Body-centred
Under what conditions does Ibuprofen typically produce crystals with better flow properties?
Crystallization from methanol
Which crystal habit shape is described as needle-like?
Acicular
What term is used to describe crystals with a single atom at the center of the top or bottom faces?
End-centred
What defines a unit cell in a crystal lattice?
The arrangement of molecules or ions within it
In a centered unit cell, where are constituent particles present?
At positions other than corners in addition to corners
What type of unit cell do crystals have when their constituent particles are only at the corner positions?
Primitive unit cells
How are crystals of a given substance bound together?
By plane surfaces called faces
What type of unit cell structure do drug molecules typically form?
Monoclinic unit cells
What influences the crystal habits of a substance?
The size of the molecules or ions in the lattice
Which process is mostly used to achieve supersaturation of solute in a solution during crystallization?
Cooling
What is the difference between an amorphous solid and a crystalline solid?
Crystalline solids have a highly ordered array of constituents, while amorphous solids do not.
What is the primary factor influencing the formation of crystalline solids when most liquids are cooled?
Temperature drop
What are the constituents that make up a crystal or crystalline solid?
Highly ordered array of constituents forming a three-dimensional network
How is crystal growth achieved during the crystallization process?
By transferring solute from the solution to the crystal state through a dissolution process
What term describes the collection of lattice points that form the three-dimensional arrangement in a crystal lattice?
Lattice sites
Test your knowledge on centered unit cell atoms, crystalline structures, and the process of crystallization in the context of pharmaceuticals. Explore the different crystal forms that APIs can take and how they impact physical properties in drugs and excipients.
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