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Questions and Answers
Creutzfeldt-Jakob disease (CJD) is a rapidly progressive ______ illness that causes death within 1 year of symptom onset.
Creutzfeldt-Jakob disease (CJD) is a rapidly progressive ______ illness that causes death within 1 year of symptom onset.
neurodegenerative
Patients typically experience a prodromal phase characterized by vague, nonspecific symptoms, such as headaches, fatigue, and ______ disorders.
Patients typically experience a prodromal phase characterized by vague, nonspecific symptoms, such as headaches, fatigue, and ______ disorders.
sleep
Neuropsychiatric symptoms are consistently seen and manifest as dementia, behavioral abnormalities, and deficits involving higher cortical function (e.g. ______).
Neuropsychiatric symptoms are consistently seen and manifest as dementia, behavioral abnormalities, and deficits involving higher cortical function (e.g. ______).
aphasia
A characteristic physical exam finding seen in patients with CJD is startle ______, wherein jerking or clenching movements of a muscle group are triggered by a loud sound (e.g. door slamming shut).
A characteristic physical exam finding seen in patients with CJD is startle ______, wherein jerking or clenching movements of a muscle group are triggered by a loud sound (e.g. door slamming shut).
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On brain MRI, CJD classically presents with enhancement of the basal ganglia and ______.
On brain MRI, CJD classically presents with enhancement of the basal ganglia and ______.
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Detection of protein 14-3-3 in cerebrospinal fluid is classically seen in patients with CJD, and it occurs due to acute ______ damage.
Detection of protein 14-3-3 in cerebrospinal fluid is classically seen in patients with CJD, and it occurs due to acute ______ damage.
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What is the best initial test for work-up of CJD?
What is the best initial test for work-up of CJD?
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Which finding is classically seen on brain MRI in patients with CJD?
Which finding is classically seen on brain MRI in patients with CJD?
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What is the hallmark EEG finding of CJD?
What is the hallmark EEG finding of CJD?
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What type of movements are triggered by a loud sound in patients with CJD?
What type of movements are triggered by a loud sound in patients with CJD?
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What protein is classically detected in the cerebrospinal fluid of patients with CJD?
What protein is classically detected in the cerebrospinal fluid of patients with CJD?
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Which type of symptoms are consistently seen in patients with CJD during the prodromal phase?
Which type of symptoms are consistently seen in patients with CJD during the prodromal phase?
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