12 Questions
Creutzfeldt-Jakob disease (CJD) is a rapidly progressive ______ illness that causes death within 1 year of symptom onset.
neurodegenerative
Patients typically experience a prodromal phase characterized by vague, nonspecific symptoms, such as headaches, fatigue, and ______ disorders.
sleep
Neuropsychiatric symptoms are consistently seen and manifest as dementia, behavioral abnormalities, and deficits involving higher cortical function (e.g. ______).
aphasia
A characteristic physical exam finding seen in patients with CJD is startle ______, wherein jerking or clenching movements of a muscle group are triggered by a loud sound (e.g. door slamming shut).
myoclonus
On brain MRI, CJD classically presents with enhancement of the basal ganglia and ______.
thalamus
Detection of protein 14-3-3 in cerebrospinal fluid is classically seen in patients with CJD, and it occurs due to acute ______ damage.
neuronal
What is the best initial test for work-up of CJD?
Brain MRI
Which finding is classically seen on brain MRI in patients with CJD?
Enhancement of the basal ganglia and thalamus
What is the hallmark EEG finding of CJD?
Periodic sharp wave complexes
What type of movements are triggered by a loud sound in patients with CJD?
Startle myoclonus
What protein is classically detected in the cerebrospinal fluid of patients with CJD?
14-3-3 protein
Which type of symptoms are consistently seen in patients with CJD during the prodromal phase?
Vague, nonspecific symptoms like headaches and fatigue
Test your knowledge of the symptoms and diagnosis of Creutzfeldt-Jakob Disease (CJD), a rapidly progressive neurodegenerative illness. Learn about the prodromal phase, neuropsychiatric symptoms, and characteristic physical exam findings associated with CJD.
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