36 Questions
What did the speaker mention about the data on COVID-19?
It is constantly changing
According to the speaker, what varies widely around the world?
Outpatient treatment of COVID-19
What did the speaker mention about the Acute Respiratory Clinic (ARC) at Emory TravelWell Center?
The first patient had recently returned from a holiday and had asthma
What disclaimer did the speaker provide about the guidance for outpatients with COVID-19?
It is still evolving and limited
Where can one find the US approach to management of COVID-19 based on evidence-based guidelines?
IDSA/NIH website
What did the speaker mention about post-COVID conditions?
They are a topic of discussion in the presentation
What is the reported mortality rate for children diagnosed with Multisystem Inflammatory Syndrome (MIS-C) after COVID-19 infection?
2%
Which factor is NOT listed as a risk factor for severe disease after COVID-19 infection?
Athleticism
What is the key focus of monoclonal therapy in the treatment of COVID-19?
Stopping virus replication
Which syndrome is characterized by severe hyperinflammatory symptoms 2-6 weeks after acute COVID-19 infection?
MIS-C
What percentage of ambulatory young adults (16-30 yrs old) experienced persistent symptoms at 6 months after mild COVID-19 infection?
52%
Which medication has been associated with reducing the risk of severe illness (hospitalization) by 70-80% in COVID-19 patients?
Monoclonal antibodies
What is the main purpose of Tocilizumab in the treatment of later-stage COVID-19 infection?
Controlling inflammation
What is the presumed efficacy of Sotrovimab against hospitalization or death in non-hospitalized patients with mild to moderate COVID-19?
70-85%
Which demographic group is NOT associated with an increased risk of Post-Acute Sequelae of SARS-CoV-2 infection (PASC)?
Female gender
What is the main purpose of Evolving paradigms in the treatment of early COVID-19 infection?
Neutralize virus and stop replication
What percentage of participants reported symptoms lasting at least 2 months after seropositive for COVID-19 according to the Sheehan Disability Scale?
40%
Which factor is NOT a possible mechanism for increased incidence of new diabetes diagnoses after COVID-19 infection?
Altered cholesterol metabolism
What is the most common initial presentation of COVID-19?
Fever, cough, and fatigue
What is the median incubation period for COVID-19?
2-5 days
What are the common symptoms reported in the USS Theodore Roosevelt COVID-19 outbreak?
Fever, cough, and fatigue
What did the human challenge study involving intranasal inoculation with pre-alpha wild type virus find as a common symptom?
Runny nose
In which clinical stage of illness does evidence of lower respiratory infection (LRI) appear?
Moderate illness
What is one of the inflammatory complications associated with severe or critical COVID-19?
Guillain-Barré syndrome
What is a potential reason for the lower rates of severe illness from Omicron?
Decreased variant virulence
Which factor is considered protective against severe illness in vaccinated persons with COVID-19?
Previous illness
Which group reported an attack rate of 74% from the Omicron variant outbreak?
Mostly vaccinated but unboosted attendees at a Christmas party
What was a common symptom reported in the Norway Christmas party outbreak associated with the Omicron variant?
Fatigue and headache
What are some of the dermatologic findings reported as potential symptoms of COVID-19?
Exanthematous rash and pernio (chilblains)
Which medication has been granted EUA for post-exposure prophylaxis of high-risk individuals who are not fully vaccinated or not expected to mount an adequate response to the vaccine?
Casirivimab-imdevimab
Which medication is a long-acting mAb that may provide protection for 6 or more months?
Tixagevimab-cilgavimab
Which medication is indicated for pre-exposure prophylaxis for ages ≥12 who are uninfected, without known recent exposure, and have moderate to severe immune compromise and may not mount an adequate response to vaccination?
Tixagevimab-cilgavimab
Which oral antiviral medication is recommended for use in mild-moderate COVID in persons aged ≥12 with risk factors for severe disease within 5 days of symptom onset and decreases the risk of hospitalizations or death by 88%?
Nirmatrelvir/ritonavir (Paxlovid)
Which oral antiviral medication is not recommended in severe renal or hepatic impairment, and has many drug-drug interactions (DDIs)?
Nirmatrelvir/ritonavir (Paxlovid)
Which oral antiviral medication has the potential to decrease the risk of hospitalization or death by 30% in adults with risk factors for severe disease within 5 days of symptom onset when there are no other treatment options?
Molnupiravir
Which medication's EUA was revoked due to Omicron resistance?
Casirivimab-imdevimab
Test your knowledge about the risk factors for severe COVID-19 disease and Multisystem Inflammatory Syndrome in Children (MIS-C). Learn about the factors associated with severe disease and mortality, as well as the characteristics of MIS-C.
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