Podcast
Questions and Answers
What was observed in Western blots from brain lysates of COVID-19 patients?
What was observed in Western blots from brain lysates of COVID-19 patients?
- Increased RyR2 oxidation and PKA phosphorylation (correct)
- No changes in RyR2 oxidation and PKA phosphorylation
- Decreased PKA phosphorylation
- Reduced calstabin2 and NOX2 bound to the channel
What was the method used to determine oxidative stress levels in brain tissues?
What was the method used to determine oxidative stress levels in brain tissues?
- Western blots depicting RyR2 oxidation
- Measuring the ratio of GSSG to GSH by an ELISA kit (correct)
- 3 [H]ryanodine binding from immunoprecipitated RyR2
- TMB substrate incubation
What was the purpose of adding TMB substrate to each well?
What was the purpose of adding TMB substrate to each well?
- To measure the ratio of GSSG to GSH
- To incubate the plate for 30 minutes at RT
- To aspirate the 3.2.1 Oxidative stress plate
- To determine the absorbance at 450 nm (correct)
Which of the following proteins was found to be dysregulated in COVID-19 brains?
Which of the following proteins was found to be dysregulated in COVID-19 brains?
What was the comparison made to determine the sample signals?
What was the comparison made to determine the sample signals?
What was the significance of the data obtained from the Western blots?
What was the significance of the data obtained from the Western blots?
What is the main mechanism of cognitive impairment associated with COVID-19?
What is the main mechanism of cognitive impairment associated with COVID-19?
Which of the following is NOT a therapeutic target for COVID-19 neurological complications?
Which of the following is NOT a therapeutic target for COVID-19 neurological complications?
What is the role of TGF-β signaling in COVID-19?
What is the role of TGF-β signaling in COVID-19?
What is the name of the protein associated with Alzheimer's disease-like signaling in COVID-19 patients?
What is the name of the protein associated with Alzheimer's disease-like signaling in COVID-19 patients?
What is the effect of SARS-CoV-2 infection on the brain?
What is the effect of SARS-CoV-2 infection on the brain?
What is the consequence of oxidative overload in COVID-19 patients?
What is the consequence of oxidative overload in COVID-19 patients?
What is proposed as a potential therapeutic target for ameliorating COVID-19 neurological symptoms?
What is proposed as a potential therapeutic target for ameliorating COVID-19 neurological symptoms?
What is associated with fibrosis in the lungs and other organs?
What is associated with fibrosis in the lungs and other organs?
What is a potential risk factor for developing AD in the future?
What is a potential risk factor for developing AD in the future?
What is reported to be upregulated in COVID-19 infection?
What is reported to be upregulated in COVID-19 infection?
What is suggested to explain the coordination deficits experienced by hospitalized COVID-19 patients?
What is suggested to explain the coordination deficits experienced by hospitalized COVID-19 patients?
What is involved in the formation of cellular fibrosis?
What is involved in the formation of cellular fibrosis?
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