COVID-19 and Alzheimer's Disease
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Questions and Answers

What was observed in Western blots from brain lysates of COVID-19 patients?

  • Increased RyR2 oxidation and PKA phosphorylation (correct)
  • No changes in RyR2 oxidation and PKA phosphorylation
  • Decreased PKA phosphorylation
  • Reduced calstabin2 and NOX2 bound to the channel

    • What was the method used to determine oxidative stress levels in brain tissues?

  • Western blots depicting RyR2 oxidation
  • Measuring the ratio of GSSG to GSH by an ELISA kit (correct)
  • 3 [H]ryanodine binding from immunoprecipitated RyR2
  • TMB substrate incubation

    • What was the purpose of adding TMB substrate to each well?

  • To measure the ratio of GSSG to GSH
  • To incubate the plate for 30 minutes at RT
  • To aspirate the 3.2.1 Oxidative stress plate
  • To determine the absorbance at 450 nm (correct)

    • Which of the following proteins was found to be dysregulated in COVID-19 brains?

    <p>Ryanodine receptor 2 (RyR2)</p> Signup and view all the answers

    What was the comparison made to determine the sample signals?

    <p>Comparison to a standard curve</p> Signup and view all the answers

    What was the significance of the data obtained from the Western blots?

    <p>Data showed a significant difference between control and COVID-19 samples</p> Signup and view all the answers

    What is the main mechanism of cognitive impairment associated with COVID-19?

    <p>Oxidative stress</p> Signup and view all the answers

    Which of the following is NOT a therapeutic target for COVID-19 neurological complications?

    <p>Ryanodine receptor/calcium release channels (RyR)</p> Signup and view all the answers

    What is the role of TGF-β signaling in COVID-19?

    <p>Activating Alzheimer's disease-like signaling</p> Signup and view all the answers

    What is the name of the protein associated with Alzheimer's disease-like signaling in COVID-19 patients?

    <p>Ryanodine receptor (RyR)</p> Signup and view all the answers

    What is the effect of SARS-CoV-2 infection on the brain?

    <p>Activating TGF-β signaling</p> Signup and view all the answers

    What is the consequence of oxidative overload in COVID-19 patients?

    <p>Increased risk of Alzheimer's disease</p> Signup and view all the answers

    What is proposed as a potential therapeutic target for ameliorating COVID-19 neurological symptoms?

    <p>Defective intracellular Ca2+ regulation</p> Signup and view all the answers

    What is associated with fibrosis in the lungs and other organs?

    <p>TGF-β activation</p> Signup and view all the answers

    What is a potential risk factor for developing AD in the future?

    <p>Prior COVID-19 infection</p> Signup and view all the answers

    What is reported to be upregulated in COVID-19 infection?

    <p>Genes involved in oxidative overload</p> Signup and view all the answers

    What is suggested to explain the coordination deficits experienced by hospitalized COVID-19 patients?

    <p>Tau protein pathology in the cerebellum</p> Signup and view all the answers

    What is involved in the formation of cellular fibrosis?

    <p>TGF-β</p> Signup and view all the answers

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