C15- descending system

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Questions and Answers

The motoneurons in the ventromedial portion of the spinal cord are responsible for the flexor muscles of the limbs.

False (B)

Short propriospinal interneurons connect motor neurons located in adjacent spinal cord segments.

True (A)

The Ia inhibitory interneuron is not involved in the stretch reflex.

False (B)

Long propriospinal interneurons facilitate communication between the cervical and sacral segments of the spinal cord.

<p>True (A)</p> Signup and view all the answers

Interneurons play a minimal role in modulating the signals within the spinal cord.

<p>False (B)</p> Signup and view all the answers

The corticospinal system allows for purposeful use of the hand and arm under the control of the spinal cord.

<p>False (B)</p> Signup and view all the answers

In cats, 40% of the frontal lobe is dedicated to the primary motor functions.

<p>True (A)</p> Signup and view all the answers

The layer that originates corticospinal fibers is predominantly the 4th layer of the cerebral cortex.

<p>False (B)</p> Signup and view all the answers

The majority of corticospinal fibers in primates are uncrossed.

<p>False (B)</p> Signup and view all the answers

In humans, corticospinal fibers directly interact with all motor neurons, including axial muscles.

<p>True (A)</p> Signup and view all the answers

Termination of the corticospinal tract in goats occurs mainly in the lumbar region.

<p>False (B)</p> Signup and view all the answers

The largest termination of the corticospinal fibers occurs in the thoracic region.

<p>False (B)</p> Signup and view all the answers

Sherrington emphasized the role of the cortex in reflex actions, stating that reflexes can only be controlled by spinal mechanisms.

<p>False (B)</p> Signup and view all the answers

The Ib interneuron is positioned directly between Ib fibers and sensory neurons.

<p>False (B)</p> Signup and view all the answers

Autogenic inhibition operates with increased intensity as muscle force increases, preventing over-exertion.

<p>True (A)</p> Signup and view all the answers

Renshaw cells are excitatory interneurons responsible for enhancing motoneuron activity.

<p>False (B)</p> Signup and view all the answers

Humans possess a unique descending system that enables them to perform voluntary movements with high precision.

<p>True (A)</p> Signup and view all the answers

All mammals exhibit the same dexterity and voluntary movement capabilities as humans.

<p>False (B)</p> Signup and view all the answers

Independent movements of fingers in humans are solely dependent on anatomical structures.

<p>False (B)</p> Signup and view all the answers

The first step in assessing hand function after a stroke is to check for independent finger movements.

<p>True (A)</p> Signup and view all the answers

The precision grip in humans is facilitated by the anatomical independence of hand muscles.

<p>False (B)</p> Signup and view all the answers

The motor neurons communicate only with short proprio spinal neurons.

<p>False (B)</p> Signup and view all the answers

The circuitry for locomotion is entirely independent of any brain modulation.

<p>False (B)</p> Signup and view all the answers

The spinal cord does not play a role in organizing voluntary movements.

<p>False (B)</p> Signup and view all the answers

Motor neurons are the final common path to skeletal muscles.

<p>True (A)</p> Signup and view all the answers

The cortex operates at a low organizational level compared to the brainstem.

<p>False (B)</p> Signup and view all the answers

The muscle's force production is the same at all lengths regardless of motor neuron discharge frequency.

<p>False (B)</p> Signup and view all the answers

The stretch reflex involves direct signaling from Ia fibers to motoneurons.

<p>True (A)</p> Signup and view all the answers

The spinal cord's motoneuron pools are disorganized without somatotopic arrangement.

<p>False (B)</p> Signup and view all the answers

The brain cannot modulate the force exerted by muscle fibers through the frequency of discharge.

<p>False (B)</p> Signup and view all the answers

Ib fibers have a role in preventing excessively high force by causing muscle relaxation.

<p>True (A)</p> Signup and view all the answers

The ventral horn of the spinal cord is comprised solely of a dorsolateral section.

<p>False (B)</p> Signup and view all the answers

The sensor and motor systems do not need to communicate for proper movement functioning.

<p>False (B)</p> Signup and view all the answers

The diencephalon and telencephalon do not communicate with the spinal cord.

<p>False (B)</p> Signup and view all the answers

The ventral corticospinal tract accounts for 20% of the corticospinal system and is homolateral.

<p>True (A)</p> Signup and view all the answers

The primary motor cortex is exclusively responsible for sensory input in the brain.

<p>False (B)</p> Signup and view all the answers

Macaques are chosen as animal models for research on the corticospinal system due to their close proximity to human brain functions.

<p>True (A)</p> Signup and view all the answers

The lateral corticospinal tract does not decussate before innervating the spinal cord.

<p>False (B)</p> Signup and view all the answers

The extended limbic system plays no role in driving human behaviors related to survival.

<p>False (B)</p> Signup and view all the answers

Neurons retrogradely labeled can show projections from various cortical areas to the corticospinal tract.

<p>True (A)</p> Signup and view all the answers

The cingulate cortex does not contribute to the corticospinal tract in humans.

<p>False (B)</p> Signup and view all the answers

The somatosensory cortex has no descending pathways to the anterior horn of the spinal cord.

<p>False (B)</p> Signup and view all the answers

The primary motor cortex is located in area 4 of the frontal lobe.

<p>True (A)</p> Signup and view all the answers

Flashcards

Ventromedial motoneurons

Motoneurons in the ventromedial portion control axial proximal muscles to stabilize the spine.

Dorsolateral portion

The enlarged region at cervical and lumbar segments supplying motor control to upper and lower limbs.

Ia inhibitory interneuron

Interneuron involved in stretch reflex and reciprocal inhibition of muscles.

Short propriospinal interneurons

Interneurons connecting motor neurons within adjacent spinal cord segments.

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Long propriospinal interneurons

Interneurons connecting motor neurons from cervical to sacral segments, aiding in posture control.

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Ib Interneuron

An interneuron connecting Ib fibers and motorneurons for autogenic inhibition.

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Corticospinal system

The pathway that controls voluntary movements, particularly of the hands and arms, under the cortex's control.

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Autogenic Inhibition

A protective reflex preventing muscle damage during excessive force exertion.

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Role of the cortex

The cortex processes all elements necessary to perform controlled movements, influencing reflexes.

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Renshaw Cells

Inhibitory interneurons activated by motoneuron branches to modulate excitability.

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Corticospinal fiber termination

The locations (cervical, thoracic, lumbar) where corticospinal fibers terminate in the spinal cord vary among species.

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Feedback Loop

A system where the output influences the input to maintain balance.

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Human vs. animal motor control

Humans have a greater contribution from the parietal lobe for movement control compared to cats.

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Descending Systems

Neural pathways that modulate movements from higher brain centers to the spinal cord.

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Locomotion Circuit

Neural circuitry in the spinal cord responsible for coordinating movement.

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Motor neuron direct interaction

In humans, corticospinal fibers directly interact with motor neurons, allowing complex motor control.

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Reflexive control

Reflexes can be consciously controlled by the cortex during purposeful movements.

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Precision Grip

The ability to use fingers independently for refined movements.

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Cerebral cortex purpose

The cortex’s function is to purposefully control hand and arm movements compared to simpler animals.

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Synergy of Movements

Coordinated action of multiple muscles to achieve precise motion.

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Corticospinal Tract

Pathways from the cortex to spinal motor neurons that influence voluntary movement.

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Uncrossed vs. crossed fibers

In primates, most corticospinal fibers are crossed, leading to motor control opposite to the body side.

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Intrinsic Muscles

Muscles within the hand that allow fine motor control and independence.

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Diencephalon

A brain region that includes the thalamus and hypothalamus, involved in autonomic and behavioral functions.

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Hypothalamus

A part of the diencephalon controlling autonomic functions and behaviors related to survival.

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Telencephalon

The largest part of the brain, it includes the cerebral cortex and is involved in higher brain functions.

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Pyramidal system

Another name for the corticospinal system, indicating its path through pyramid-shaped nuclei in the brainstem.

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Cerebral cortex

The outer layer of the brain involved in complex functions, including perception and action.

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Pupillary reflex

An involuntary reflex that controls the diameter of the pupil in response to light.

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Reticular formation

A network of neurons in the brainstem that manages sleep-wake states and arousal.

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Decussation

The crossing of nerve fibers from one side of the body to the other, especially in the brainstem.

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Hierarchical movement system

A structured network for organizing voluntary movements involving cortex, brainstem, and spinal cord.

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Spinal cord function

Part of the CNS that organizes movements and modulates muscle force through motor neurons.

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Motor neurons

Final pathway controlling muscle contractions and reflexes, originating in the spinal cord.

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Force modulation

Control of muscle force by frequency of motor neuron discharge and motor unit recruitment.

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Size principle

Recruiting smaller motor units first, increasing to larger units as force needs rise.

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Stretch reflex

A reflex action that adjusts muscle excitability based on its length without brain intervention.

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Ib fibers function

Fibers from tendon organs that help relax muscles when excessive force is detected.

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Somatotopic organization

Arrangement of motoneuron pools in the spinal cord based on specific body regions.

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Motor and sensor system communication

Coordination between motor and sensory systems for efficient movement and function.

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Study Notes

Cortical Control of Movement

  • Voluntary movement is controlled hierarchically, involving the cortex, brainstem, and spinal cord. No single part is more essential.
  • Lou Gehrig's disease highlights the crucial role of motor neurons. Without them, the spinal cord cannot organize movements, either reflexive or voluntary. Motor neurons are the final pathway to skeletal muscles.
  • The cortex is the highest level, but this isn't because it's physically dominant. It controls lower levels (brainstem and spinal cord) to orchestrate movement.

Spinal Cord Organization

  • The spinal cord is part of the central nervous system (CNS), while nerves are peripheral.
  • The brain directly controls muscle force through two primary mechanisms:
    • Firing frequency of motor neurons
    • Number of motor units recruited (size principle)
  • Muscles also have inherent length-dependent force production. A change in muscle length alters the force produced at the same firing frequency.
  • Reflexive actions, like the stretch reflex, bypass higher brain centers for faster response. Ia fibers directly adjust excitability of motoneurons based on muscle length.
  • Ib fibers provide feedback from tendon organs to regulate force. Excessive force causes muscle relaxation.
  • Motor neurons synapse in lamina IX of the anterior horn. They are organized into pools and typically involve multiple segments.
  • Sensory and motor systems communicate in the same way, with a shared language. Dysfunction can occur if they don't communicate correctly.

Descending Systems

  • Descending systems from the cortex and brainstem control movement in the spinal cord in both contralateral and ipsilateral ways, mediating the body's posture and movements.
  • Ventral corticospinal tract is homolateral, but works bilaterally through spinal cord commissure, controlling epaxial and proximal muscles.
  • Lateral corticospinal tract is the major decussating (crossing over), portion controlling 80% of movements.
  • Medial descending pathways come from the brainstem (tectum, reticular formation, vestibular nuclei) controlling medial parts, for posture & balance.
  • Lateral pathways are from the red nucleus (rubrospinal tract) and control distal parts of limbs.
  • Medial pathways control epaxial and proximal muscles; lateral pathways control distal limb muscles.
  • There are two families of systems: medial and lateral. Medial systems control primarily posture, axial, and proximal movements. Lateral systems control more specific and distal movements.

Brainstem Descending Pathways

  • Multiple pathways exist, besides corticospinal. They are responsible for both voluntary and involuntary actions. The rubrospinal tract originates from the red nucleus mimicking the lateral corticospinal tract in function.
  • Other brainstem pathways are for emotional motor control, including communication with segments of the autonomic nervous system. These systems can modulate spinal cord activity beyond simple movement.

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