Coronary Artery Stenosis and Angina

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Questions and Answers

What is the term used to describe macrophages that have engulfed LDL particles?

  • Foam cells (correct)
  • Smooth muscle cells
  • Fatty streaks
  • Endothelial cells

What is the term for the fibrous cap that covers a growing atheroma?

  • Foam cells
  • Smooth muscle cells
  • Elastin
  • Interstitial collagen (correct)

What is the characteristic feature of longstanding atheromas?

  • Fatty streaks
  • LDL particle entry
  • Endothelial permeability
  • Calcium accumulation (correct)

What term is often used to refer to atherosclerotic coronary artery disease (ASCAD)?

<p>CAD (A)</p> Signup and view all the answers

What refers to the cardiac consequences of insufficient coronary blood supply to meet myocardial needs?

<p>Ischemic heart disease (B)</p> Signup and view all the answers

Which of the following factors influences the development of ASCAD?

<p>All of the above (D)</p> Signup and view all the answers

What started as a cohort study in 1948 involving Americans aged 28-62 with no history of heart attack or stroke?

<p>Framingham Heart study (B)</p> Signup and view all the answers

What is a characteristic feature of the plaques vulnerable to rupture in acute coronary syndromes?

<p>Large lipid-rich necrotic core (D)</p> Signup and view all the answers

In the context of acute coronary syndrome, what may lead to myocardial ischemia on minimal exertion or at rest?

<p>Formation of a platelet-fibrin thrombus (C)</p> Signup and view all the answers

How is Chronic Coronary Syndrome categorized?

<p>Patients with stabilized symptoms within 1 year of an ACS (C)</p> Signup and view all the answers

Which diagnostic test is essential in the quick diagnosis of acute coronary syndrome?

<p>Performing an ECG as soon as feasible (C)</p> Signup and view all the answers

What is a key factor that may indicate an acute coronary syndrome?

<p>Rest angina lasting more than 20 minutes (A)</p> Signup and view all the answers

Why is education of patients and their families essential in cases of acute coronary syndrome?

<p>To ensure quick recognition and response to symptoms (D)</p> Signup and view all the answers

Which of the following statements about angina is most accurate?

<p>Angina on exertion usually indicates at least 90% area reduction of a major coronary artery. (B)</p> Signup and view all the answers

What is the purpose of summoning an advanced life support ambulance upon a 911 responder's arrival in cases suggesting myocardial infarction?

<p>To provide transportation to a specialist hospital for PCI if needed (B)</p> Signup and view all the answers

What is the characteristic quality of discomfort experienced during angina?

<p>Tightness, squeezing, or pressure (B)</p> Signup and view all the answers

What is crucial for making a quick diagnosis of acute coronary syndrome in Vancouver and many cities?

<p>Obtaining and transmitting an ECG as soon as feasible (C)</p> Signup and view all the answers

What is a common 'angina equivalent' symptom that some patients may experience?

<p>Shortness of breath (D)</p> Signup and view all the answers

What are likely precipitating factors for angina discomfort?

<p>Exertion or emotional upset (A)</p> Signup and view all the answers

Why does angina typically occur when there is an imbalance between myocardial oxygen demand and supply?

<p>Caused by transient myocardial ischemia (C)</p> Signup and view all the answers

What is one common symptom that may accompany angina?

<p>Nausea (D)</p> Signup and view all the answers

When is angina likely to be more readily precipitated?

<p>On first arising in the morning (C)</p> Signup and view all the answers

What is the primary basis for making a diagnosis of angina?

<p>'Selective testing' based on history (C)</p> Signup and view all the answers

What is the biomarker of choice for diagnosing acute cardiac events?

<p>Troponin (Tp) (D)</p> Signup and view all the answers

Which enzyme may be used as an alternative to troponin in some situations?

<p>Creatine kinase-MB (CK-MB) (C)</p> Signup and view all the answers

What action is typically taken if a patient presents with ST elevation in the clinical setting of an ACS?

<p>Coronary balloon angioplasty and stent (Primary PCI) (A)</p> Signup and view all the answers

What diagnosis is assigned to a patient with NSTE-ACS who has no elevation of troponin?

<p>Unstable angina (C)</p> Signup and view all the answers

Which of the following stimuli is NOT mentioned as a possible cause of endothelial irritation in Atherosclerotic Coronary Artery Disease (ASCAD)?

<p>High HDL levels (C)</p> Signup and view all the answers

In CAD spectrum, which condition is characterized by a sequence of endothelial irritation followed by the expression of adhesion molecules on the endothelial surface?

<p>Stable coronary disease (B)</p> Signup and view all the answers

What is the underlying pathophysiology discussed for unstable angina in the CAD spectrum?

<p>Adhesion of circulating monocytes to endothelium (C)</p> Signup and view all the answers

Which stage of CAD spectrum is characterized by adhesion of circulating monocytes that may migrate through the endothelium and into the intima where they transform into macrophages?

<p>Non-ST Elevation Myocardial Infarction (NSTEMI) (C)</p> Signup and view all the answers

Which condition in the CAD spectrum presents with clinical similarities to unstable angina but with elevated cardiac biomarkers?

<p>Non-ST Elevation Myocardial Infarction (NSTEMI) (D)</p> Signup and view all the answers

Which type of cardiovascular disease involves diseases of the heart and vasculature, including peripheral arterial disease and cerebrovascular disease?

<p>Cardiovascular Disease (CVD) (A)</p> Signup and view all the answers

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