Coordination and Molecular Complexes
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Questions and Answers

What is the primary characteristic of coordination complexes?

  • They consist exclusively of hydrogen bonds.
  • They involve a metal ion bonded to ligands by coordinate covalent bonds. (correct)
  • They are formed by non-covalent interactions.
  • They are only formed with organic compounds.
  • Which type of complex primarily involves non-covalent forces?

  • Metallic complexes
  • Molecular complexes (correct)
  • Coordination complexes
  • Ionic complexes
  • What factor does NOT influence protein binding?

  • Molecular weight of the drug (correct)
  • Concentration of the drug and protein
  • pH and temperature of the solution
  • Affinity of the drug to the protein
  • Which of the following statements about the consequences of protein binding is incorrect?

    <p>Protein binding enhances drug distribution to target tissues.</p> Signup and view all the answers

    Which type of molecular complex is formed between a small molecule and a large molecule?

    <p>Iodine and polyvinylpyrrolidone</p> Signup and view all the answers

    What is the most abundant plasma protein in the human body?

    <p>Albumin</p> Signup and view all the answers

    How do ion exchange resins function in drug delivery systems?

    <p>They swap ions in solution with ions attached to the resin.</p> Signup and view all the answers

    Which of the following interactions is characteristic of coordination complexes?

    <p>Covalent bonding between ligands and metal ions</p> Signup and view all the answers

    Study Notes

    Coordination Complexes

    • Formed by a metal ion and ligands, bound by coordinate covalent bonds.
    • Ligands donate electrons to the metal, forming a Lewis acid-base reaction.
    • Example: Silver-ammonia complex, ([Ag(NH3)2]^+).

    Molecular Complexes

    • Held together by non-covalent interactions: hydrogen bonds, van der Waals forces, electrostatic forces.
    • Examples: drug-protein binding, surfactant micelles.

    Ion Exchange Resins

    • Swap ions in a solution with ions attached to the resin.
    • This can purify drug solutions by removing unwanted ions.
    • Drugs can form ion pairs with the resin, leading to controlled release.

    Molecular Complexes by Size

    • Small Molecule–Small Molecule: Example: Theophylline and ethylenediamine forming aminophylline.
    • Small Molecule–Large Molecule: Example: Drug-protein complexes like iodine with polyvinylpyrrolidone.
    • Large Molecule–Large Molecule: Examples include protein-protein interactions.

    Protein Binding

    • Affinity: Strength of the drug-protein bond.
    • Concentration: Amount of drug and protein present.
    • pH and temperature: Impact protein shape and binding ability.

    Albumin

    • Most abundant plasma protein.

    Consequences of Protein Binding

    • Slowed Drug Action: Bound drugs have difficulty crossing cell membranes.
    • Prolonged Drug Duration: Drugs remain in the bloodstream for longer.
    • Limited Distribution: Only free drugs can interact with target tissues.

    Drug Interactions from Protein Binding

    • Competing drugs may displace each other from protein binding sites.
    • Increased free drug concentration can enhance or lead to toxic effects.
    • Example: Warfarin displacement can increase bleeding risk.

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    Description

    Explore the fascinating world of coordination complexes, molecular interactions, and ion exchange resins through this insightful quiz. Learn about how ligands and metal ions interact, the significance of hydrogen bonding, and drug-protein binding mechanisms. Test your knowledge on various types of molecular complexes and their applications.

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