Podcast
Questions and Answers
Which law regulates controlled substances in the United States?
Which law regulates controlled substances in the United States?
- Food, Drug, and Cosmetic Act
- Controlled Substances Act (CSA) of 1970 (correct)
- Veterinary Practice Act
- Federal Drug Administration Act
Which agency regulates controlled substances under the CSA?
Which agency regulates controlled substances under the CSA?
- Food and Drug Administration (FDA)
- Drug Enforcement Administration (DEA) (correct)
- Centers for Disease Control and Prevention (CDC)
- Department of Agriculture (USDA)
How are controlled substances classified under the CSA?
How are controlled substances classified under the CSA?
By their potential for abuse or misuse
Which of the following is true regarding the classification of controlled substances?
Which of the following is true regarding the classification of controlled substances?
What can cause a change in the control level of a drug?
What can cause a change in the control level of a drug?
Which of the following is a general requirement for controlled substances?
Which of the following is a general requirement for controlled substances?
How often must controlled substances undergo inventory checks at a minimum?
How often must controlled substances undergo inventory checks at a minimum?
What must veterinarians do to legally purchase, administer, or dispense controlled substances?
What must veterinarians do to legally purchase, administer, or dispense controlled substances?
How do storage and record-keeping requirements for controlled substances vary?
How do storage and record-keeping requirements for controlled substances vary?
Describe the characteristics of Class 1 controlled drugs.
Describe the characteristics of Class 1 controlled drugs.
What are the two examples of class 1 controlled drugs?
What are the two examples of class 1 controlled drugs?
Describe the description of a class II controlled drug
Describe the description of a class II controlled drug
What are examples of a class II drugs?
What are examples of a class II drugs?
describe what a class 3 controlled drug is.
describe what a class 3 controlled drug is.
What are examples of a class 3 drug?
What are examples of a class 3 drug?
Describe what a Class IV drug is?
Describe what a Class IV drug is?
What are examples of Class 4 drugs?
What are examples of Class 4 drugs?
Describe the class 5 drug
Describe the class 5 drug
Under what condition is the use of opioids permitted in food-producing animals?
Under what condition is the use of opioids permitted in food-producing animals?
Which act allows the use of opioids in food-producing animals under specific conditions?
Which act allows the use of opioids in food-producing animals under specific conditions?
What resource should be consulted to determine the most current withdrawal interval recommendations for opioid use in food-producing animals?
What resource should be consulted to determine the most current withdrawal interval recommendations for opioid use in food-producing animals?
What schedule classification does tramadol fall under as a controlled drug?
What schedule classification does tramadol fall under as a controlled drug?
Is tramadol currently FDA-approved as a veterinary medication?
Is tramadol currently FDA-approved as a veterinary medication?
Where would you NOT find tramadol listed as a veterinary-approved medication?
Where would you NOT find tramadol listed as a veterinary-approved medication?
Under the Animal Medicinal Drug Use Clarification Act (AMDUCA), the FDA can prohibit the use of an entire class of drugs in selected animal species if:
Under the Animal Medicinal Drug Use Clarification Act (AMDUCA), the FDA can prohibit the use of an entire class of drugs in selected animal species if:
What is another reason the FDA may prohibit the extra-label use of a drug or drug class?
What is another reason the FDA may prohibit the extra-label use of a drug or drug class?
Can the FDA restrict extra-label drug use only for specific species, indications, or routes of administration?
Can the FDA restrict extra-label drug use only for specific species, indications, or routes of administration?
What should happen if a prohibited drug is mistakenly used in a food animal?
What should happen if a prohibited drug is mistakenly used in a food animal?
What does current law say about compounding animal drugs from bulk drug substances?
What does current law say about compounding animal drugs from bulk drug substances?
Which FDA guidance document outlines conditions where the agency does not intend to take action against compounding drugs from bulk substances for animals?
Which FDA guidance document outlines conditions where the agency does not intend to take action against compounding drugs from bulk substances for animals?
Match the groups to its correct description
Match the groups to its correct description
What are the group 1 drugs?
What are the group 1 drugs?
What are the group 2 dugs?
What are the group 2 dugs?
Which animals are included in the prohibition of extra-label use for Group I drugs?
Which animals are included in the prohibition of extra-label use for Group I drugs?
Why is chloramphenicol prohibited in food-producing animals?
Why is chloramphenicol prohibited in food-producing animals?
Which drug is a synthetic member of the chloramphenicol family that lacks the para-nitro group and is approved for use in pigs and cattle?
Which drug is a synthetic member of the chloramphenicol family that lacks the para-nitro group and is approved for use in pigs and cattle?
What is true about thiamphenicol?
What is true about thiamphenicol?
Florfenicol is effective for treatment of bovine and swine _____ disease
Florfenicol is effective for treatment of bovine and swine _____ disease
What are the restrictions for florfenicol treatment?
What are the restrictions for florfenicol treatment?
What is the FDA-approved use of clenbuterol?
What is the FDA-approved use of clenbuterol?
Why is clenbuterol illegal for use in food-producing animals?
Why is clenbuterol illegal for use in food-producing animals?
Clenbuterol residues in food products are particularly dangerous for which group(s) of people?
Clenbuterol residues in food products are particularly dangerous for which group(s) of people?
What has the TFDA established regarding clenbuterol residues in food products?
What has the TFDA established regarding clenbuterol residues in food products?
Why is cooking ineffective in removing clenbuterol residues from food?
Why is cooking ineffective in removing clenbuterol residues from food?
What was diethylstilbestrol (DES) originally prescribed for?
What was diethylstilbestrol (DES) originally prescribed for?
What reproductive effects were observed in female offspring of DES-treated patients?
What reproductive effects were observed in female offspring of DES-treated patients?
What reproductive issues were detected in male and female offspring of DES-treated patients?
What reproductive issues were detected in male and female offspring of DES-treated patients?
Why was DES used in food animal production?
Why was DES used in food animal production?
DES use in food producing species has been prohibited although it is still marketed in the U.S.
DES use in food producing species has been prohibited although it is still marketed in the U.S.
What was the first group of antimicrobials prohibited from extra-label use by the FDA?
What was the first group of antimicrobials prohibited from extra-label use by the FDA?
Why was the use of fluoroquinolones restricted in poultry?
Why was the use of fluoroquinolones restricted in poultry?
In which food-producing animals is the use of enrofloxacin still legal?
In which food-producing animals is the use of enrofloxacin still legal?
What change was made to the label of enrofloxacin?
What change was made to the label of enrofloxacin?
What is required when using enrofloxacin and danofloxacin?
What is required when using enrofloxacin and danofloxacin?
What was the primary use of nitroimidazoles in turkeys?
What was the primary use of nitroimidazoles in turkeys?
Why was the use of nitroimidazoles prohibited in food animals?
Why was the use of nitroimidazoles prohibited in food animals?
Which of the following nitroimidazole drugs has been linked to in vivo and in vitro potential carcinogenesis?
Which of the following nitroimidazole drugs has been linked to in vivo and in vitro potential carcinogenesis?
What was nitroimidazoles' recommended use in bulls before being prohibited?
What was nitroimidazoles' recommended use in bulls before being prohibited?
What is the current legal status of nitroimidazoles in food animals?
What is the current legal status of nitroimidazoles in food animals?
What were nitrofurans originally approved to treat in poultry and swine?
What were nitrofurans originally approved to treat in poultry and swine?
Why were systemic nitrofuran products banned from use in food-producing species in 1991?
Why were systemic nitrofuran products banned from use in food-producing species in 1991?
For what conditions were topical nitrofuran products still available for food animals after the 1991 ban?
For what conditions were topical nitrofuran products still available for food animals after the 1991 ban?
What led to the complete prohibition of nitrofurans in food animals in 2002?
What led to the complete prohibition of nitrofurans in food animals in 2002?
What is the current legal status of nitrofurans in food animals?
What is the current legal status of nitrofurans in food animals?
Which is the only glycopeptide used in veterinary medicine?
Which is the only glycopeptide used in veterinary medicine?
Why has vancomycin use been necessary in veterinary medicine?
Why has vancomycin use been necessary in veterinary medicine?
What concern has been linked to glycopeptide use in poultry and swine?
What concern has been linked to glycopeptide use in poultry and swine?
Vancomycin is considered a last-resort treatment for which type of infection?
Vancomycin is considered a last-resort treatment for which type of infection?
What is the legal status of vancomycin in food animals?
What is the legal status of vancomycin in food animals?
Why are antiviral drugs used in poultry in some countries outside the United States?
Why are antiviral drugs used in poultry in some countries outside the United States?
What is the legal status of antiviral drugs for poultry in the United States?
What is the legal status of antiviral drugs for poultry in the United States?
The prohibition of antiviral drugs in poultry in the U.S. extends to which species?
The prohibition of antiviral drugs in poultry in the U.S. extends to which species?
How do adamantane antiviral drugs work?
How do adamantane antiviral drugs work?
Why is extra-label use of cephalosporins prohibited in food-producing animals?
Why is extra-label use of cephalosporins prohibited in food-producing animals?
Which zoonotic foodborne pathogen is of particular concern regarding cephalosporin resistance?
Which zoonotic foodborne pathogen is of particular concern regarding cephalosporin resistance?
In which food-producing animals are cephalosporins legally marketed for use?
In which food-producing animals are cephalosporins legally marketed for use?
What formulations of cephalosporins are available for use in livestock?
What formulations of cephalosporins are available for use in livestock?
Why is ceftiofur of particular concern, despite not being used in human medicine?
Why is ceftiofur of particular concern, despite not being used in human medicine?
What is the general rule regarding the extra-label use (ELDU) of indexed drugs in food-producing animals?
What is the general rule regarding the extra-label use (ELDU) of indexed drugs in food-producing animals?
What is the exception to the prohibition of indexed drug use in food-producing animals?
What is the exception to the prohibition of indexed drug use in food-producing animals?
What was the original purpose of adding gentian violet to poultry feed?
What was the original purpose of adding gentian violet to poultry feed?
How did gentian violet help prevent growth retardation in poultry?
How did gentian violet help prevent growth retardation in poultry?
What is the FDA’s stance on the use of gentian violet in food animals?
What is the FDA’s stance on the use of gentian violet in food animals?
Why is gentian violet no longer permitted for use in poultry feed?
Why is gentian violet no longer permitted for use in poultry feed?
What are some alternatives to gentian violet as a mold inhibitor?
What are some alternatives to gentian violet as a mold inhibitor?
Phenylbutazone in humans can induce ______ disorders like _____
Phenylbutazone in humans can induce ______ disorders like _____
The use of Phenylbutazone has been prohibited in female dairy cattle older than :
The use of Phenylbutazone has been prohibited in female dairy cattle older than :
What NSAID is used for lactating dairy cattle instead of Phyynylbutazone?
What NSAID is used for lactating dairy cattle instead of Phyynylbutazone?
Flunixin meglumine should only be used IV excluding veal calves and swine
Flunixin meglumine should only be used IV excluding veal calves and swine
Why are sulfonamides generally prohibited in adult dairy cattle?
Why are sulfonamides generally prohibited in adult dairy cattle?
Which of the following statements accurately describes the legal use of sulfadimethoxine and sulfaethoxypyridazine in adult dairy cattle?
Which of the following statements accurately describes the legal use of sulfadimethoxine and sulfaethoxypyridazine in adult dairy cattle?
What is the primary concern regarding the use of sulfonamides in sheep and goats?
What is the primary concern regarding the use of sulfonamides in sheep and goats?
Which factor is most critical in determining the legality of sulfonamide usage in adult dairy cattle?
Which factor is most critical in determining the legality of sulfonamide usage in adult dairy cattle?
Why did the FDA withdraw approval of metamizole (dipyrone) for human products?
Why did the FDA withdraw approval of metamizole (dipyrone) for human products?
In what animal species and for what purpose has the FDA approved dipyrone injection?
In what animal species and for what purpose has the FDA approved dipyrone injection?
Which of the following animals is dipyrone specifically prohibited from being used in?
Which of the following animals is dipyrone specifically prohibited from being used in?
What is the primary concern regarding the use of colloidal silver in animals?
What is the primary concern regarding the use of colloidal silver in animals?
Why is the use or storage of dimethyl sulfoxide (DMSO) and colloidal silver prohibited on dairy operations involving lactating dairy cattle?
Why is the use or storage of dimethyl sulfoxide (DMSO) and colloidal silver prohibited on dairy operations involving lactating dairy cattle?
What is argyria, and which substance is it associated with?
What is argyria, and which substance is it associated with?
While DMSO gel is suggested for reducing acute swelling due to trauma, what is a significant health concern associated with its use?
While DMSO gel is suggested for reducing acute swelling due to trauma, what is a significant health concern associated with its use?
Flashcards
Controlled Substances Act (CSA)
Controlled Substances Act (CSA)
Regulates controlled substances in the United States.
Drug Enforcement Administration (DEA)
Drug Enforcement Administration (DEA)
Regulates controlled substances under the CSA.
Potential for abuse or misuse
Potential for abuse or misuse
Controlled substances are classified by this under the CSA.
Higher
Higher
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Change in abuse potential
Change in abuse potential
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Securely
Securely
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Biennially
Biennially
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Register with the DEA
Register with the DEA
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Vary between states
Vary between states
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Class 1 Controlled Drugs
Class 1 Controlled Drugs
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Examples of Class 1 drugs
Examples of Class 1 drugs
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Class II Controlled Drug
Class II Controlled Drug
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Examples of Class II drugs
Examples of Class II drugs
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Class III Controlled Drug
Class III Controlled Drug
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Examples of Class III drugs
Examples of Class III drugs
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Class IV Drug
Class IV Drug
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Examples of Class IV drugs
Examples of Class IV drugs
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Sulfonamides
Sulfonamides
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Sulfonamide ELDU in Dairy Cattle
Sulfonamide ELDU in Dairy Cattle
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Prohibited Sulfonamide Use
Prohibited Sulfonamide Use
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Sulfonamide Use in Sheep/Goats
Sulfonamide Use in Sheep/Goats
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Definition of Adult Dairy Cattle
Definition of Adult Dairy Cattle
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Dipyrone's Human Use
Dipyrone's Human Use
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Metamizole FDA Status
Metamizole FDA Status
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Dipyrone Use in Horses
Dipyrone Use in Horses
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Dipyrone Restrictions
Dipyrone Restrictions
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Dipyrone Safety Concerns
Dipyrone Safety Concerns
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DMSO (Dimethyl sulfoxide)
DMSO (Dimethyl sulfoxide)
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Argyria
Argyria
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DMSO/Colloidal Silver - Dairy Ban
DMSO/Colloidal Silver - Dairy Ban
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Colloidal silver concerns
Colloidal silver concerns
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Colloidal silver side effects
Colloidal silver side effects
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Study Notes
- Sulfonamides are banned in adult dairy cattle, defined as any dairy cattle older than 20 months, regardless of milking status.
- Sulfonamides have demonstrated carcinogenicity in lab animals
Sulfadimethoxine and Sulfaethoxypyridazine
- Sulfadimethoxine and sulfaethoxypyridazine are currently labeled for use in adult dairy cattle.
- Using sulfadimethoxine and sulfaethoxypyridazine according to the label is permitted.
- Extra-label drug use (ELDU) of sulfadimethoxine and sulfaethoxypyridazine is prohibited.
- Using any other sulfonamide in an adult dairy cow is a violation.
Sheep and Goats
- Sulfonamide use is discouraged in sheep or goats due to potential milk residues, despite not being expressly prohibited.
Dypirone
- Concerns exist regarding human use of dypirone due to potential teratogenic effects, prolonged bleeding time, and agranulocytosis.
- The FDA removed approval of metamizole for human products.
- In 2019, the FDA approved dypirone injection for use in horses.
- Dypirone is not approved for animals intended for human consumption.
- Dypirone is not approved for food-producing animals, including lactating dairy animals.
Dimethyl Sulfoxide and Colloidal Silver
- Dimethyl sulfoxide and colloidal silver are not to be used or stored on dairy operations or fed to lactating dairy cattle.
Dimethyl Sulfoxide (DMSO)
- Dimethyl sulfoxide gel is recommended as a topical application to reduce acute swelling due to trauma.
- It raises concerns about carcinogenic diseases.
Colloidal Silver
- Human consumption of silver may result in argyria (permanent ashen-gray or blue discoloration of the skin, conjunctiva, and internal organs).
- Colloidal silver use to treat a serious illness in animals may endanger the animal's health by delaying timely, appropriate treatment.
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Know the authorities, schedules of controlled drugs and special conditions, prohibited drugs in food animals etc
