Podcast
Questions and Answers
What is the primary objective of controlled-release or modified-release products?
What is the primary objective of controlled-release or modified-release products?
What is the duration of drug release for the estradiol vaginal ring insert (Estring, Pharmacia & Upjohn)?
What is the duration of drug release for the estradiol vaginal ring insert (Estring, Pharmacia & Upjohn)?
What is the mechanism of rate-controlled delivery systems?
What is the mechanism of rate-controlled delivery systems?
What is the primary difference between targeted release and rate-controlled delivery?
What is the primary difference between targeted release and rate-controlled delivery?
Signup and view all the answers
What is the classification of controlled-release products according to the USP?
What is the classification of controlled-release products according to the USP?
Signup and view all the answers
What is the primary purpose of a delayed-release dosage form?
What is the primary purpose of a delayed-release dosage form?
Signup and view all the answers
What is the duration of drug release for levonorgestrel subdermal implants (Nor-plant System, Weth-Ayerst)?
What is the duration of drug release for levonorgestrel subdermal implants (Nor-plant System, Weth-Ayerst)?
Signup and view all the answers
What is the main difference between an extended-release dosage form and a conventional dosage form?
What is the main difference between an extended-release dosage form and a conventional dosage form?
Signup and view all the answers
What is the typical release pattern of an extended-release product?
What is the typical release pattern of an extended-release product?
Signup and view all the answers
What is a potential disadvantage of extended-release dosage forms?
What is a potential disadvantage of extended-release dosage forms?
Signup and view all the answers
What is the term used to describe the sudden and total release of the drug from an extended-release dosage form?
What is the term used to describe the sudden and total release of the drug from an extended-release dosage form?
Signup and view all the answers
What is the benefit of extended-release dosage forms in terms of drug blood levels?
What is the benefit of extended-release dosage forms in terms of drug blood levels?
Signup and view all the answers
Study Notes
Controlled/Targeted Drug Release Delivery Systems
Characteristics of Controlled-Release Products
- Designed to release medication in a controlled manner, at a predetermined rate, duration, and location
- Aim to achieve and maintain optimum therapeutic blood levels of a drug
Non-Oral Controlled-Release Delivery Systems
- Include ocular, parenteral, subdermal, vaginal, and transdermal products
- Examples: estradiol vaginal ring insert (Estring, Pharmacia & Upjohn), levonorgestrel subdermal implants (Nor-plant System, Weth-Ayerst)
Targeted Release
- Isolates or concentrates a drug in a body region, tissue, or site for absorption or for drug action
Rate-Controlled Delivery
- Applied to certain types of drug delivery systems where the rate of drug delivery is controlled by device features rather than physiological or environmental conditions
- USP differentiates rate-controlled products as extended release and delayed-release
Extended Release vs. Delayed Release
- Delayed-release dosage form: designed to release the drug at a time other than promptly after administration
- Extended-release dosage form: allows for a reduction in dosing frequency compared to conventional dosage forms
Slow Release
- Synonyms: prolonged action (PA), sustained action (SA), long acting (LA), controlled-release (CR), extended release (ER), sustained release (SR)
- Provides an immediate release of the drug followed by gradual and continual release of additional amounts of drug
Advantages of Extended-Release Products
- Reduction in drug blood level fluctuations
- Reduction in dosing frequency
- Enhanced patient convenience and compliance
- Reduction in adverse side effects
- Enhanced therapeutic benefit
- Reduction in overall health care costs
Disadvantages of Extended-Release Products
- Loss of flexibility in adjusting the drug dose
- Increased risk of sudden and total drug release or “dose dumping” due to technology failure or patient misuse
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge on controlled-release or modified-release products, designed to release medication in a controlled manner, at a predetermined rate, duration, and location. This quiz covers the concepts of orally administered and non-oral controlled-release delivery systems, including ocular and parenteral routes.
