5 Questions
Which hormone primarily stimulates the release of adrenal steroid hormones?
Adrenocorticotropic hormone (ACTH)
What mainly controls mineralocorticoid secretions?
Renin-angiotensin-aldosterone system
What is the result of increased free cortisol levels in the body?
Inhibition of CRH release
What hormone is primarily responsible for the release of ACTH from the anterior pituitary?
Corticotropin-releasing hormone (CRH)
The control of adrenal steroid hormones secretion is primarily regulated through which axis?
Hypothalamic-pituitary-adrenal axis
Study Notes
Control of Adrenal Steroid Hormones Secretion
- Physiological control of adrenal steroid hormones secretion, especially glucocorticoids (cortisol), occurs through the hypothalamic-pituitary-adrenal axis.
- The hypothalamic-pituitary-adrenal axis involves the production of hypothalamic corticotropin-releasing hormone (CRH), which stimulates the release of ACTH from the anterior pituitary gland.
- ACTH stimulates the release of adrenal steroid hormones, mainly glucocorticoids (cortisol) and androgens.
- Mineralocorticoids secretion is controlled mainly by the renin-angiotensin-aldosterone system and to a lesser extent by the hypothalamic-pituitary-adrenal axis.
Negative Feedback
- Increased free cortisol levels cause negative feedback inhibition to the hypothalamic-pituitary-adrenal axis through suppression of CRH.
- Negative feedback mechanism involves the inhibition of CRH production in the hypothalamus, which in turn reduces ACTH release from the pituitary gland.
This quiz covers the physiological control of adrenal steroid hormones secretion, focusing on glucocorticoids and the hypothalamic-pituitary-adrenal axis.
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