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Questions and Answers
What is the main transformation process of a fibroblast as it matures?
What is the main transformation process of a fibroblast as it matures?
- It changes into a fibrocyte (correct)
- It transforms into a myofibroblast
- It becomes a macrophage
- It evolves into an adipocyte
Which of the following is a function of fibroblasts?
Which of the following is a function of fibroblasts?
- Engulfing bacteria
- Cleaning foreign bodies from wounds
- Forming collagen and elastin (correct)
- Generating energy through fat storage
What characterizes the nucleus of fixed macrophages or histiocytes?
What characterizes the nucleus of fixed macrophages or histiocytes?
- It is indented or kidney-shaped (correct)
- It is large and pale
- It is spherical and bright
- It contains no chromatin
How do fixed macrophages contribute to the immune response?
How do fixed macrophages contribute to the immune response?
Which cell type can form multinucleated giant cells during immune responses?
Which cell type can form multinucleated giant cells during immune responses?
What component do fibroblasts contribute to the extracellular matrix?
What component do fibroblasts contribute to the extracellular matrix?
What is the role of myofibroblasts in wound healing?
What is the role of myofibroblasts in wound healing?
What is the primary origin of fixed macrophages?
What is the primary origin of fixed macrophages?
What is a distinct feature of unilocular adipocytes?
What is a distinct feature of unilocular adipocytes?
What is the primary function of multilocular adipocytes?
What is the primary function of multilocular adipocytes?
Which characteristic is true for mesenchymal cells?
Which characteristic is true for mesenchymal cells?
Where are pericytes typically located?
Where are pericytes typically located?
What is a key difference between unilocular and multilocular adipocytes?
What is a key difference between unilocular and multilocular adipocytes?
What type of staining is used to visualize fat cells in sections?
What type of staining is used to visualize fat cells in sections?
What feature is characteristic of endothelial cells?
What feature is characteristic of endothelial cells?
Which of the following is a function of pericytes?
Which of the following is a function of pericytes?
Flashcards
Fibroblast
Fibroblast
A type of connective tissue cell that produces the fibers and matrix of connective tissue.
Fibrocyte
Fibrocyte
A mature, less active fibroblast.
Macrophage function
Macrophage function
Plays a role in body defense by phagocytizing (engulfing) foreign particles and debris.
Macrophages
Macrophages
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Myofibroblast
Myofibroblast
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Adipocyte
Adipocyte
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Connective tissue fibers
Connective tissue fibers
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CT matrix
CT matrix
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Unilocular Adipocyte
Unilocular Adipocyte
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Multilocular Adipocyte
Multilocular Adipocyte
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Mesenchymal Cell
Mesenchymal Cell
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Pericyte
Pericyte
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Endothelial Cell
Endothelial Cell
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Adipose Tissue
Adipose Tissue
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Functions of unilocular adipocytes
Functions of unilocular adipocytes
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Functions of Multilocular adipocytes
Functions of Multilocular adipocytes
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Study Notes
Connective Tissue: Fixed Cells
-
Fibroblast and Fibrocyte:
- Develop from pericytes and mesenchymal cells.
- Mature fibroblasts become less active and change into fibrocytes.
- Fibroblasts form connective tissue fibers and matrix.
- Abundant in areolar connective tissue.
- Fibroblasts can transform into contractile myofibroblasts, rich in contractile filaments.
- Crucial in wound closure during healing.
-
Fixed Macrophages (Histiocytes):
- Originate from blood monocytes migrating to connective tissue.
- Motile cells with multiple processes (pseudopodia).
- Irregular cell membrane due to pseudopodia.
- Cytoplasm is basophilic, containing lysosomes and phagocytosed materials.
- Indented or kidney-shaped nucleus, rich in heterochromatin (dark).
- Distinguished from fibroblasts by pale nucleus.
- Stained with vital stains like Trypan blue or black Indian ink.
-
Adipose Cells (Adipocytes):
- Derived from mesenchymal cells after fat accumulation.
- Unilocular:
- Large, oval cells with flattened peripheral nucleus (signet ring).
- Contain a large fat globule.
- Multilocular:
- Present in newborns.
- Many fat globules and mitochondria.
- Rounded nucleus
- Primarily for heat production.
- Found in neck, shoulders, back, axilla, and para-aortic regions in newborns.
Other Cells
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Mesenchymal Cells (UMCs):
- Embryonic, branched cells with large oval, basophilic nuclei.
- Found primarily in embryonic tissues.
- Differentiate into various connective tissue cell types.
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Pericytes:
- Pale, branched cells with cytoplasmic processes.
- Located externally to endothelium of capillaries and small venules.
- Considered mesenchymal cells, persisting throughout adulthood.
- Contribute to fibroblasts and other cells.
Endothelial Cells
- Line the inner surface of blood capillaries and vessels.
- Adults consider them connective tissue.
- Functions:
- Synthesize type IV collagen.
- Can divide to form new capillaries in damaged tissue.
- Produce their own basal lamina.
Reticular Cells
- Found in reticular connective tissue.
- Modified fibroblasts.
- Secrete reticular fibers (part of CT network).
- Branched cells with processes.
- Contribute to the stroma of glands, organs, and bone marrow.
- Remove cellular debris in lymphatic systems.
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Description
Explore the essential components of fixed cells in connective tissue, including fibroblasts, macrophages, and adipocytes. Understand their origins, functions, and significance in tissue structure and repair. This quiz provides a comprehensive overview for students studying histology.
