Podcast
Questions and Answers
Which type of conjunctiva is characterized by tight adherence to the tarsus and is prone to papillary folds in inflammatory conditions?
Which type of conjunctiva is characterized by tight adherence to the tarsus and is prone to papillary folds in inflammatory conditions?
- Limbus
- Bulbar Conjunctiva
- Palpebral Conjunctiva (correct)
- Fornix Conjunctiva
In a patient suspected of having sarcoidosis, which site within the conjunctiva is most likely to yield diagnostic granulomas upon biopsy?
In a patient suspected of having sarcoidosis, which site within the conjunctiva is most likely to yield diagnostic granulomas upon biopsy?
- Fornix Conjunctiva (correct)
- Bulbar Conjunctiva
- Limbus
- Palpebral Conjunctiva
What type of epithelium is found in the bulbar conjunctiva?
What type of epithelium is found in the bulbar conjunctiva?
- Nonkeratinizing stratified squamous epithelium (correct)
- Keratinized stratified squamous epithelium
- Pseudostratified columnar epithelium
- Transitional epithelium
Where does the conjunctival epithelium transition into corneal epithelium?
Where does the conjunctival epithelium transition into corneal epithelium?
Through which lymph nodes do malignancies of the conjunctiva primarily spread?
Through which lymph nodes do malignancies of the conjunctiva primarily spread?
Which of the following conditions is NOT a cause of conjunctival scarring?
Which of the following conditions is NOT a cause of conjunctival scarring?
Loss of goblet cells in the conjunctiva, leading to decreased mucin production, results in which condition?
Loss of goblet cells in the conjunctiva, leading to decreased mucin production, results in which condition?
What is a potential consequence of extensive surgical removal of the conjunctiva?
What is a potential consequence of extensive surgical removal of the conjunctiva?
In the context of intraepithelial lesions of the conjunctiva, which treatments are commonly used?
In the context of intraepithelial lesions of the conjunctiva, which treatments are commonly used?
What primary factor contributes to the development of both pinguecula and pterygium?
What primary factor contributes to the development of both pinguecula and pterygium?
Where on the eye do pingueculae typically occur?
Where on the eye do pingueculae typically occur?
Which of the following best describes a pinguecula?
Which of the following best describes a pinguecula?
What is the origin point of a pterygium?
What is the origin point of a pterygium?
Which corneal layer does a pterygium invade?
Which corneal layer does a pterygium invade?
Why might a clinician submit a pterygium tissue sample for histopathology?
Why might a clinician submit a pterygium tissue sample for histopathology?
A patient presents with inflammation of the fornix conjunctiva. Enlarged follicles are noted. Which of the following is the most likely cause?
A patient presents with inflammation of the fornix conjunctiva. Enlarged follicles are noted. Which of the following is the most likely cause?
A farmer who spends long hours in the sun without eye protection develops a growth on the nasal side of his eye that extends onto the cornea. The growth is causing mild astigmatism. What is the most likely diagnosis?
A farmer who spends long hours in the sun without eye protection develops a growth on the nasal side of his eye that extends onto the cornea. The growth is causing mild astigmatism. What is the most likely diagnosis?
A patient with ocular cicatricial pemphigoid is evaluated. What pathophysiological change in the conjunctiva contributes most significantly to the patient's dry eye symptoms?
A patient with ocular cicatricial pemphigoid is evaluated. What pathophysiological change in the conjunctiva contributes most significantly to the patient's dry eye symptoms?
During an eye exam, a yellowish, raised lesion is noted adjacent to the cornea, but it does not extend onto the cornea itself. Considering the etiology, what is the most appropriate advice for the patient?
During an eye exam, a yellowish, raised lesion is noted adjacent to the cornea, but it does not extend onto the cornea itself. Considering the etiology, what is the most appropriate advice for the patient?
A patient is diagnosed with marginal zone B-cell lymphoma affecting the conjunctiva. Which specific area of the conjunctiva is the most likely site for this type of lymphoma?
A patient is diagnosed with marginal zone B-cell lymphoma affecting the conjunctiva. Which specific area of the conjunctiva is the most likely site for this type of lymphoma?
Flashcards
Palpebral Conjunctiva
Palpebral Conjunctiva
Tightly adhered to the tarsus; inflammation here can lead to papillary folds.
Fornix Conjunctiva
Fornix Conjunctiva
Contains goblet cells, accessory lacrimal tissue, and lymphoid tissue; follicles enlarge in viral conjunctivitis.
Bulbar Conjunctiva
Bulbar Conjunctiva
Nonkeratinizing stratified squamous epithelium covering the sclera.
Limbus
Limbus
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Conjunctival Scarring Pathophysiology
Conjunctival Scarring Pathophysiology
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Pinguecula
Pinguecula
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Pterygium
Pterygium
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Etiology of Pinguecula and Pterygium
Etiology of Pinguecula and Pterygium
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Study Notes
- The conjunctiva is examined by functional anatomy which contains zonal divisions
Palpebral Conjunctiva
- Tightly adheres to the tarsus
- When inflamed, papillary folds form; this is seen in allergic and bacterial conjunctivitis
Fornix Conjunctiva
- Has pseudostratified columnar epithelium and goblet cells
- Contains accessory lacrimal tissue
- Rich in lymphoid tissue, follicles enlarge if there is viral conjunctivitis
- Used as a diagnostic site for granulomas in sarcoidosis, with biopsies yielding up to 50% success
- Site for marginal zone B-cell lymphoma
Bulbar Conjunctiva
- Contains nonkeratinizing stratified squamous epithelium
Limbus
- The junction between the sclera and cornea
- Transitions from conjunctival to corneal epithelium
Lymphatic Drainage
- Drains to the parotid and submandibular lymph nodes
- Malignancies spread through these routes
Conjunctival Scarring
- Scarring can result from multiple causes including Chlamydia trachomatis (trachoma), alkali injuries, ocular cicatricial pemphigoid, drug reactions, or surgery
Pathophysiology
- Scarring leads to a Loss of goblet cells, which reduces mucin production
- Mucin is required for aqueous tear film adherence
- Leads to dry eye even with normal aqueous production
Clinical Consideration
- Excessive surgical removal may cause goblet cell or ductule loss
- Cryotherapy or topical chemotherapy can treat Intraepithelial lesions
Pinguecula and Pterygium
- They caused by actinic (UV) damage
- Occur in sun-exposed areas, specifically, the interpalpebral fissure
Pinguecula
- Yellowish submucosal elevation
- Located near the limbus
- Does not invade cornea
Pterygium
- Fibrovascular growth
- Starts at the limbus and migrates onto cornea
- Invades Bowman’s layer
- Does not cross pupillary axis
- May cause mild astigmatism
- Submit tissue for histopathology to rule out neoplasia
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