Conjunctiva Anatomy

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Questions and Answers

Which type of conjunctiva is characterized by tight adherence to the tarsus and is prone to papillary folds in inflammatory conditions?

  • Limbus
  • Bulbar Conjunctiva
  • Palpebral Conjunctiva (correct)
  • Fornix Conjunctiva

In a patient suspected of having sarcoidosis, which site within the conjunctiva is most likely to yield diagnostic granulomas upon biopsy?

  • Fornix Conjunctiva (correct)
  • Bulbar Conjunctiva
  • Limbus
  • Palpebral Conjunctiva

What type of epithelium is found in the bulbar conjunctiva?

  • Nonkeratinizing stratified squamous epithelium (correct)
  • Keratinized stratified squamous epithelium
  • Pseudostratified columnar epithelium
  • Transitional epithelium

Where does the conjunctival epithelium transition into corneal epithelium?

<p>Limbus (C)</p> Signup and view all the answers

Through which lymph nodes do malignancies of the conjunctiva primarily spread?

<p>Parotid and submandibular lymph nodes (A)</p> Signup and view all the answers

Which of the following conditions is NOT a cause of conjunctival scarring?

<p>Actinic (UV) damage (A)</p> Signup and view all the answers

Loss of goblet cells in the conjunctiva, leading to decreased mucin production, results in which condition?

<p>Dry eye despite normal aqueous production (D)</p> Signup and view all the answers

What is a potential consequence of extensive surgical removal of the conjunctiva?

<p>Loss of goblet cells or ductules (C)</p> Signup and view all the answers

In the context of intraepithelial lesions of the conjunctiva, which treatments are commonly used?

<p>Cryotherapy or topical chemotherapy (A)</p> Signup and view all the answers

What primary factor contributes to the development of both pinguecula and pterygium?

<p>Actinic (UV) damage (A)</p> Signup and view all the answers

Where on the eye do pingueculae typically occur?

<p>Sun-exposed area near the limbus (C)</p> Signup and view all the answers

Which of the following best describes a pinguecula?

<p>A yellowish submucosal elevation near the limbus that does not invade the cornea (A)</p> Signup and view all the answers

What is the origin point of a pterygium?

<p>Limbus (B)</p> Signup and view all the answers

Which corneal layer does a pterygium invade?

<p>Bowman’s layer (A)</p> Signup and view all the answers

Why might a clinician submit a pterygium tissue sample for histopathology?

<p>To rule out neoplasia (A)</p> Signup and view all the answers

A patient presents with inflammation of the fornix conjunctiva. Enlarged follicles are noted. Which of the following is the most likely cause?

<p>Viral Conjunctivitis (D)</p> Signup and view all the answers

A farmer who spends long hours in the sun without eye protection develops a growth on the nasal side of his eye that extends onto the cornea. The growth is causing mild astigmatism. What is the most likely diagnosis?

<p>Pterygium (D)</p> Signup and view all the answers

A patient with ocular cicatricial pemphigoid is evaluated. What pathophysiological change in the conjunctiva contributes most significantly to the patient's dry eye symptoms?

<p>Loss of goblet cells leading to decreased mucin production (B)</p> Signup and view all the answers

During an eye exam, a yellowish, raised lesion is noted adjacent to the cornea, but it does not extend onto the cornea itself. Considering the etiology, what is the most appropriate advice for the patient?

<p>Use artificial tears and wear sunglasses (C)</p> Signup and view all the answers

A patient is diagnosed with marginal zone B-cell lymphoma affecting the conjunctiva. Which specific area of the conjunctiva is the most likely site for this type of lymphoma?

<p>Fornix conjunctiva (B)</p> Signup and view all the answers

Flashcards

Palpebral Conjunctiva

Tightly adhered to the tarsus; inflammation here can lead to papillary folds.

Fornix Conjunctiva

Contains goblet cells, accessory lacrimal tissue, and lymphoid tissue; follicles enlarge in viral conjunctivitis.

Bulbar Conjunctiva

Nonkeratinizing stratified squamous epithelium covering the sclera.

Limbus

Junction between the sclera and cornea; transition from conjunctival to corneal epithelium.

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Conjunctival Scarring Pathophysiology

Loss of goblet cells leads to decreased mucin, causing dry eye.

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Pinguecula

Yellowish submucosal elevation near the limbus that does not invade the cornea.

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Pterygium

Fibrovascular growth originating at the limbus that migrates onto the cornea, potentially causing mild astigmatism.

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Etiology of Pinguecula and Pterygium

Actinic (UV) damage.

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Study Notes

  • The conjunctiva is examined by functional anatomy which contains zonal divisions

Palpebral Conjunctiva

  • Tightly adheres to the tarsus
  • When inflamed, papillary folds form; this is seen in allergic and bacterial conjunctivitis

Fornix Conjunctiva

  • Has pseudostratified columnar epithelium and goblet cells
  • Contains accessory lacrimal tissue
  • Rich in lymphoid tissue, follicles enlarge if there is viral conjunctivitis
  • Used as a diagnostic site for granulomas in sarcoidosis, with biopsies yielding up to 50% success
  • Site for marginal zone B-cell lymphoma

Bulbar Conjunctiva

  • Contains nonkeratinizing stratified squamous epithelium

Limbus

  • The junction between the sclera and cornea
  • Transitions from conjunctival to corneal epithelium

Lymphatic Drainage

  • Drains to the parotid and submandibular lymph nodes
  • Malignancies spread through these routes

Conjunctival Scarring

  • Scarring can result from multiple causes including Chlamydia trachomatis (trachoma), alkali injuries, ocular cicatricial pemphigoid, drug reactions, or surgery

Pathophysiology

  • Scarring leads to a Loss of goblet cells, which reduces mucin production
  • Mucin is required for aqueous tear film adherence
  • Leads to dry eye even with normal aqueous production

Clinical Consideration

  • Excessive surgical removal may cause goblet cell or ductule loss
  • Cryotherapy or topical chemotherapy can treat Intraepithelial lesions

Pinguecula and Pterygium

  • They caused by actinic (UV) damage
  • Occur in sun-exposed areas, specifically, the interpalpebral fissure

Pinguecula

  • Yellowish submucosal elevation
  • Located near the limbus
  • Does not invade cornea

Pterygium

  • Fibrovascular growth
  • Starts at the limbus and migrates onto cornea
  • Invades Bowman’s layer
  • Does not cross pupillary axis
  • May cause mild astigmatism
  • Submit tissue for histopathology to rule out neoplasia

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