Questions and Answers
What are Conjugated Estrogens also known as?
What is the therapeutic class of Conjugated Estrogens?
Hormone
What pharmacologic class do Conjugated Estrogens belong to?
Estrogen; hormone replacement
What is the primary indication for Conjugated Estrogens?
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Name one use of Conjugated Estrogens in cancer treatment.
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What should be used for administration of vaginal cream?
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Conjugated Estrogens are contraindicated in pregnant patients.
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List one adverse effect of Conjugated Estrogens.
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Conjugated Estrogens may lower the risk of ______ in some patients.
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Match the following warnings or contraindications with their appropriate descriptions:
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Study Notes
Conjugated Estrogens Overview
- Conjugated estrogens include Cenestin, Enjuvia, and Premarin.
- All belong to the therapeutic class of hormones.
Pharmacological Classification
- Classified as estrogen and hormone replacement therapy.
Actions and Uses
- Contains a mix of natural and synthetic plant estrogens.
- Primary use for treating moderate to severe menopausal symptoms due to decreased estrogen from ovaries.
- Also indicated for vulvar and vaginal atrophy, dyspareunia, female hypogonadism, and post-oophorectomy therapy.
- Approved for palliative treatment of prostate and certain breast cancers.
- Positive effects include increased bone density and lowered LDL cholesterol.
- May reduce coronary artery disease and colon cancer risk.
- Usually combined with progestin for postmenopausal replacement therapy.
- Intramuscular (IM) or intravenous (IV) routes can be used for dysfunctional uterine bleeding.
Administration Alerts
- Use a calibrated dosage applicator for vaginal cream administration.
- For IM or IV use, reconstitute by removing 5 mL of air before injecting diluent, gently agitate to dissolve.
- Administer IV slowly at 5 mg/min.
- Classified as Pregnancy Category X.
Adverse Effects
- Increased risk of myocardial infarction (MI), stroke, breast cancer, dementia, and venous thromboembolism.
- Decreased risk of hip fractures and colorectal cancer noted.
Black Box Warnings
- Higher endometrial cancer risk in postmenopausal women.
- Co-administration with medroxyprogesterone raises breast cancer risk.
- Alone, estrogens increase risks for stroke, deep vein thrombosis (DVT), MI, pulmonary embolism, and dementia.
Contraindications
- Contraindicated for pregnant individuals and those with known/suspected breast or estrogen-dependent tumors.
- Caution advised for patients with a history of thromboembolic disease, lipid disorders, liver disease, or abnormal uterine bleeding.
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Description
This quiz covers an overview of conjugated estrogens, including key medications such as Cenestin, Enjuvia, and Premarin. It discusses their pharmacological classification, actions, uses, and administrative alerts. Test your knowledge on hormone replacement therapy and its applications.
