Conformational Polymorphism and Eutectic Point Definition
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Questions and Answers

What is the main characteristic of a compound that exhibits conformational polymorphism?

  • Low solubility in water
  • High melting point
  • Ability to exist in multiple crystalline states (correct)
  • Low vapor pressure

Which of the following statements about the eutectic point is true?

  • It is only applicable to organic compounds
  • It is the lowest temperature at which the liquid phase can exist (correct)
  • It is the highest temperature at which the solid phase can exist
  • It refers to the point where vapor pressure is highest

How does dry heat sterilization differ from autoclaving in terms of advantages?

  • Dry heat sterilization is faster
  • Autoclaving is more effective against spores (correct)
  • Dry heat sterilization does not require high temperatures
  • Autoclaving can sterilize items sensitive to moisture

Which sterilization method is best suited for items that are sensitive to moisture?

<p>Dry heat sterilization (C)</p> Signup and view all the answers

Why is ethylene oxide gas sterilization considered a versatile method?

<p>It can sterilize heat- and moisture-sensitive items (A)</p> Signup and view all the answers

Which property of an emulsifying agent is described by the HLB (Hydrophilic Lipophilic Balance) system?

<p>The ability to interact with both hydrophilic and lipophilic phases of an emulsion (D)</p> Signup and view all the answers

Which of the following is NOT a common instability mechanism observed in suspensions and emulsions?

<p>Diffusion (B)</p> Signup and view all the answers

In a colloidal dispersion, the Tindall effect refers to the:

<p>Scattering of light by the colloidal particles (D)</p> Signup and view all the answers

Which of the following is a characteristic of Brownian movement in a colloidal dispersion?

<p>It is the random motion of particles due to collisions with molecules in the medium (A)</p> Signup and view all the answers

Zeta potential in a colloidal dispersion is a measure of the:

<p>Electrical potential at the surface of the colloidal particles (D)</p> Signup and view all the answers

Which of the following is the MOST important factor that influences the equilibrium solubility of a drug?

<p>Temperature (D)</p> Signup and view all the answers

What is the relationship between the melting point of a drug and its solubility?

<p>Melting point and solubility are inversely related (C)</p> Signup and view all the answers

Which of the following chemical properties MOST influences the water solubility of a drug?

<p>Dipole moment (A)</p> Signup and view all the answers

What is the significance of the eutectic point in the solubility of drugs?

<p>It represents the minimum melting point of a drug (A)</p> Signup and view all the answers

Which of the following is the MOST important factor that determines the rate of dissolution of a drug?

<p>Particle size (D)</p> Signup and view all the answers

Which of the following statements regarding melting point depression is correct?

<p>It is the reduction of the melting point of a material with a decrease in its size. (C)</p> Signup and view all the answers

Which of the following statements about vapor pressure is incorrect?

<p>It depends on the atmospheric pressure and the presence of other vapors in the air. (A)</p> Signup and view all the answers

Which of the following is not a physicochemical property used to test chemical substances?

<p>Conformational polymorphism (C)</p> Signup and view all the answers

What is the eutectic point?

<p>The temperature at which a mixture of two or more components melts and solidifies simultaneously. (A)</p> Signup and view all the answers

Which of the following statements about vapor pressure is true?

<p>It is a measure of the tendency of a liquid to evaporate. (A)</p> Signup and view all the answers

Which statement is true regarding the vapor pressure of a liquid mixture?

<p>The total vapor pressure of a liquid mixture is equal to the sum of the vapor pressures of the individual components, weighted by their mole fractions. (C)</p> Signup and view all the answers

What is the primary factor that determines the melting point depression of a solid when a solute is added?

<p>The concentration of the solute. (D)</p> Signup and view all the answers

Which statement is true regarding conformational polymorphism?

<p>It occurs when a compound exists in different conformational states in the solid state. (A)</p> Signup and view all the answers

What is the eutectic point of a binary system?

<p>The temperature at which both components in a binary system are in equilibrium with each other in the solid and liquid phases. (C)</p> Signup and view all the answers

What is the primary factor that determines the physicochemical properties of a chemical substance?

<p>The intermolecular forces present in the substance. (B)</p> Signup and view all the answers

Which property of an emulsifying agent is described by the HLB (Hydrophilic Lipophilic Balance) system?

<p>The ability to stabilize emulsions (C)</p> Signup and view all the answers

What is the main characteristic of a compound that exhibits conformational polymorphism?

<p>It has multiple stable crystal structures (C)</p> Signup and view all the answers

In a colloidal dispersion, the Tindall effect refers to the:

<p>Scattering of light by the colloidal particles (B)</p> Signup and view all the answers

Which of the following statements about the eutectic point is true?

<p>It represents the point of minimum melting point (B)</p> Signup and view all the answers

Which of the following is NOT a common instability mechanism observed in suspensions and emulsions?

<p>Conformational polymorphism (C)</p> Signup and view all the answers

Which of the following is a characteristic of Brownian movement in a colloidal dispersion?

<p>It is a measure of the random motion of the colloidal particles (C)</p> Signup and view all the answers

Zeta potential in a colloidal dispersion is a measure of the:

<p>Degree of dispersion and stability of the colloidal system (D)</p> Signup and view all the answers

Which property of a compound is directly related to its vapor pressure?

<p>Melting point (B)</p> Signup and view all the answers

Which of the following is a characteristic of a compound that exhibits conformational polymorphism?

<p>It has multiple stable crystal structures (B)</p> Signup and view all the answers

How does the melting point of a compound change as a result of the addition of a second component (solute) to form a solution?

<p>The melting point decreases (B)</p> Signup and view all the answers

Which of the following statements accurately describes the concept of conformational polymorphism?

<p>It refers to the ability of a compound to exist in multiple crystal structures with different molecular conformations. (B)</p> Signup and view all the answers

What is the primary factor that determines the vapor pressure of a liquid or solid substance?

<p>The strength of intermolecular forces within the substance. (A)</p> Signup and view all the answers

Which of the following statements accurately describes the eutectic point of a binary system?

<p>It is the temperature at which both components in a binary mixture undergo a phase change from solid to liquid. (A)</p> Signup and view all the answers

In the context of physicochemical properties, what is the significance of melting point depression?

<p>It is the lowering of the melting point of a solvent due to the addition of a solute, forming a eutectic mixture. (D)</p> Signup and view all the answers

Which of the following physicochemical properties is most relevant in determining the stability and solubility of a compound in a given solvent?

<p>Zeta potential (D)</p> Signup and view all the answers

What is the definition of dosage form?

<p>The physical form of a dose of drug (A)</p> Signup and view all the answers

Which Act prohibits the distribution of any new drug without prior filling of a New Drug Application (NDA)?

<p>The Federal Food, Drug, and Cosmetic Act of 1938 (B)</p> Signup and view all the answers

What does an Investigational New Drug application (IND) involve?

<p>Submission to the FDA for drug approval (A)</p> Signup and view all the answers

What distinguishes the Durham-Humphrey Amendment of 1951?

<p>Legal distinction between prescription and Over-The-Counter (OTC) drugs (D)</p> Signup and view all the answers

Which step follows the FDA review in the drug development process?

<p>Scale up to manufacturing (D)</p> Signup and view all the answers

What is the main purpose of the Comprehensive Drug Abuse Prevention & Control Act of 1970?

<p>Control and regulate drugs that have potential for abuse (D)</p> Signup and view all the answers

Which component is required before a new drug product can be distributed?

<p>FDA approval and filling of a New Drug Application (NDA) (B)</p> Signup and view all the answers

What is the main function of emulsifying agents in emulsions?

<p>Stabilizing emulsions by reducing interfacial tension (C)</p> Signup and view all the answers

Which method can be used to increase the stability of suspensions according to the text?

<p>Applying external forces like ultrasonication (D)</p> Signup and view all the answers

What is a common ingredient found in both suspensions and emulsions that aids in stabilization?

<p>Stabilizers (D)</p> Signup and view all the answers

Which type of emulsion has water as the continuous phase according to the text?

<p>Oil-in-water emulsion (D)</p> Signup and view all the answers

What property is NOT a desired characteristic of a well-formulated suspension?

<p>Low stability (C)</p> Signup and view all the answers

How can the stability of an emulsion be increased based on the information given?

<p>Adding stabilizers (D)</p> Signup and view all the answers

Which of the following is a critical role played by surfactants in suspensions and emulsions?

<p>Reducing interfacial tension (D)</p> Signup and view all the answers

What effect does adjusting pH have on the stability of a suspension according to the text?

<p>Increases stability (B)</p> Signup and view all the answers

Which of the following is NOT a component of the oil phase in topical dosage forms?

<p>Propylene glycol (A)</p> Signup and view all the answers

What is the primary purpose of the ointment sterilization process?

<p>To kill any microorganisms present in the ointment (D)</p> Signup and view all the answers

Which of the following is NOT a regulatory requirement for topical dosage forms?

<p>Optimizing the viscosity of the formulation (C)</p> Signup and view all the answers

Which layer of the skin is primarily composed of keratinocytes and provides a barrier against environmental factors?

<p>Epidermis (A)</p> Signup and view all the answers

Which of the following is a key step in the incorporation method for preparing topical dosage forms?

<p>Dispersing the ingredients in a suitable vehicle (C)</p> Signup and view all the answers

What is the primary function of the dermis layer of the skin?

<p>Containing blood vessels and nerves to support the epidermis (B)</p> Signup and view all the answers

Which sterilization method is most suitable for items that are sensitive to heat and moisture?

<p>Ethylene oxide gas sterilization (A)</p> Signup and view all the answers

What is the primary function of the subcutaneous tissue layer of the skin?

<p>Storing fat and insulating the body (B)</p> Signup and view all the answers

What is the deepest layer of skin?

<p>Subcutaneous tissue (D)</p> Signup and view all the answers

Which condition is likely to be associated with a high partial pressure of CO2 in the blood?

<p>Fatigue and confusion (C)</p> Signup and view all the answers

What role does a cosurfactant play in stabilizing an emulsion?

<p>Reducing the interfacial tension between immiscible liquids (A)</p> Signup and view all the answers

Which ointment base is occlusive and provides a barrier against moisture loss?

<p>Petrolatum-based ointments (C)</p> Signup and view all the answers

What distinguishes a dispersed system from a solution?

<p>Particles in a solution settle over time (C)</p> Signup and view all the answers

What is the main advantage of transdermal drug delivery compared to other forms of drug delivery?

<p>Improved patient compliance due to controlled release of medication over an extended period (C)</p> Signup and view all the answers

Which ointment base is emollient and helps soften and soothe the skin?

<p>Lanolin-based ointments (C)</p> Signup and view all the answers

What effect does a low partial pressure of CO2 have on the body?

<p>Respiratory alkalosis (C)</p> Signup and view all the answers

Which ointment base is water-soluble and can be easily washed off the skin?

<p>Hydrophilic bases (B)</p> Signup and view all the answers

What is the primary function of a surfactant in stabilizing an emulsion?

<p>Reducing particle size (B)</p> Signup and view all the answers

What is the relationship between the dermis and epidermis?

<p>The dermis is located beneath the epidermis and contains blood vessels, nerve endings, hair follicles, and sweat glands. (A)</p> Signup and view all the answers

Which mixture would be considered homogenous at a molecular level?

<p>Solution (B)</p> Signup and view all the answers

What symptoms might be linked to an abnormal pH balance due to CO2 levels?

<p>Fatigue and confusion (B)</p> Signup and view all the answers

What is the function of the subcutaneous tissue?

<p>It provides cushioning and helps regulate body temperature. (B)</p> Signup and view all the answers

What is the purpose of classifying ointment bases based on their physical and chemical properties?

<p>To understand the different mechanisms by which ointment bases interact with the skin. (B)</p> Signup and view all the answers

What is the role of a cosurfactant when added to a surfactant in an emulsion?

<p>Enhancing emulsion stability (A)</p> Signup and view all the answers

What physicochemical property of a drug substance affects the absorption efficiency when in the unionized state?

<p>Ionized state (D)</p> Signup and view all the answers

Which physicochemical property leads to faster drug dissolution in the GI tract?

<p>Amorphous form (B)</p> Signup and view all the answers

In the context of drug substances, what formulation factor plays a crucial role in determining the absorption rate from the GI tract?

<p>Type of base used (B)</p> Signup and view all the answers

Which physiologic factor can substantially affect the dissolution of drugs in the GI tract before absorption?

<p>Gastric emptying time (B)</p> Signup and view all the answers

Which physicochemical property of a drug substance influences its dissolution rate due to requiring more energy to break crystal habit?

<p>Solubility (C)</p> Signup and view all the answers

What is the main purpose of the Kefauver-Harris Amendments of 1962?

<p>To ensure drugs are both safe and effective before FDA approval (C)</p> Signup and view all the answers

What is a key characteristic of a Goal Drug according to the text?

<p>Minimal dosing frequency (B)</p> Signup and view all the answers

Which of the following is a major goal of cGMP as described in the text?

<p>Regulating drug manufacturing practices (D)</p> Signup and view all the answers

Describe the role of USP/NF as outlined in the text.

<p>Defining packaging and labeling standards (C)</p> Signup and view all the answers

What did the Comprehensive Drug Abuse Prevention and Control Act of 1970 achieve according to the text?

<p>Consolidated laws governing stimulants, narcotics, and other drugs (D)</p> Signup and view all the answers

What is the primary purpose of the Comprehensive Drug Abuse Prevention & Control Act of 1970?

<p>To regulate the manufacture, importation, and distribution of controlled substances (D)</p> Signup and view all the answers

What is the primary function of the Investigational New Drug (IND) application?

<p>To initiate clinical trials and obtain exemption for interstate shipment of investigational drugs (B)</p> Signup and view all the answers

Which of the following federal enactments established the legal distinction between prescription and over-the-counter drugs?

<p>The Durham-Humphrey Amendment of 1951 (A)</p> Signup and view all the answers

Which federal enactment prohibits the distribution of any new drug or drug product without prior filing of a New Drug Application (NDA) and FDA approval?

<p>The Federal Food, Drug, and Cosmetic Act of 1938 (D)</p> Signup and view all the answers

What is the definition of a dosage form according to the text?

<p>The physical form in which a dose of a drug is presented (C)</p> Signup and view all the answers

What is the primary mechanism by which drugs are absorbed into the body?

<p>Passive diffusion (B)</p> Signup and view all the answers

What is the purpose of the United States Pharmacopeia (USP) General Chapter <797>?

<p>It details the requirements for pharmaceutical compounding of sterile preparations. (B)</p> Signup and view all the answers

What is the 'first-pass effect' in drug absorption?

<p>The degradation or alteration of a drug by the liver and intestines after oral administration. (D)</p> Signup and view all the answers

Which of the following is NOT a component of the United States Pharmacopeia/National Formulary (USP/NF)?

<p>Guidelines for drug scheduling (D)</p> Signup and view all the answers

What is the primary purpose of the Comprehensive Drug Abuse Prevention & Control Act of 1970?

<p>To regulate the manufacturing and distribution of controlled substances. (C)</p> Signup and view all the answers

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