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Questions and Answers
How can the presence of amyloid fibrils be confirmed?
How can the presence of amyloid fibrils be confirmed?
- Congo red binding leading to red birefringence under polarized light
- Recognition of apple-green birefringence under polarized light after Congo red staining (correct)
- Appearance on light microscopy
- Thioflavine-T binding producing a blue fluorescence
Which staining technique can determine the type of amyloidosis?
Which staining technique can determine the type of amyloidosis?
- Hematoxylin and eosin staining
- Gram staining
- Immunohistochemical staining of kappa and lambda light chains (correct)
- Periodic acid-Schiff staining
How can cardiac involvement in amyloidosis be suspected?
How can cardiac involvement in amyloidosis be suspected?
- Low platelet count
- Presence of fever
- Arrhythmia or heart block on electrocardiogram (correct)
- Elevated white blood cell count
What is a common feature of patients with primary nerve, kidney, or liver involvement in amyloidosis?
What is a common feature of patients with primary nerve, kidney, or liver involvement in amyloidosis?
Which imaging technique can help detect restrictive cardiomyopathy related to amyloidosis?
Which imaging technique can help detect restrictive cardiomyopathy related to amyloidosis?
Which clinical suspicion may remain if evaluation for other causes of symptoms is unrevealing?
Which clinical suspicion may remain if evaluation for other causes of symptoms is unrevealing?
What characteristic appearance of amyloid fibrils can be observed under polarized light after binding to Congo red?
What characteristic appearance of amyloid fibrils can be observed under polarized light after binding to Congo red?
Why might biopsy sections less than 6 microns thick not stain appropriately with Congo red despite the presence of amyloid fibrils?
Why might biopsy sections less than 6 microns thick not stain appropriately with Congo red despite the presence of amyloid fibrils?
Which method is preferred for determining the type of amyloidosis once the histologic diagnosis of amyloid is made?
Which method is preferred for determining the type of amyloidosis once the histologic diagnosis of amyloid is made?
What is the characteristic appearance of amyloid fibrils under electron microscopy?
What is the characteristic appearance of amyloid fibrils under electron microscopy?
Which staining method produces an intense yellow-green fluorescence in the presence of amyloid?
Which staining method produces an intense yellow-green fluorescence in the presence of amyloid?
What is the characteristic appearance of amyloid under hematoxylin and eosin staining on biopsy sections?
What is the characteristic appearance of amyloid under hematoxylin and eosin staining on biopsy sections?
What is the typical diameter of amyloid fibrils seen in renal amyloidosis?
What is the typical diameter of amyloid fibrils seen in renal amyloidosis?
Where are the mesangial cells and mesangial matrix usually located in a capillary tuft affected by amyloidosis?
Where are the mesangial cells and mesangial matrix usually located in a capillary tuft affected by amyloidosis?
What is the similarity between the thickness of the glomerular capillary wall and the tubular basement membranes in amyloidosis?
What is the similarity between the thickness of the glomerular capillary wall and the tubular basement membranes in amyloidosis?
Which staining method is typically used to visualize amyloid deposits under a microscope?
Which staining method is typically used to visualize amyloid deposits under a microscope?
In which type of glomerulonephritis are the amyloid fibrils smaller compared to those seen in renal amyloidosis?
In which type of glomerulonephritis are the amyloid fibrils smaller compared to those seen in renal amyloidosis?
What is the typical number of cells per capillary tuft in a case of renal amyloidosis?
What is the typical number of cells per capillary tuft in a case of renal amyloidosis?
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