25 Questions
Which of the following is a protein structure validation program?
PROCHECK
What is the main purpose of molecular docking in the drug discovery process?
Modeling the interaction between a small molecule and a protein
What type of interactions are involved in protein-protein interactions (PPIs)?
Electrostatic forces, hydrogen bonding, and the hydrophobic effect
Which of the following is a ligand database used in docking programs?
PubChem
What is the main purpose of the Human Reference Interactome (HuRI) map?
To chart interactions between human proteins
Which type of cellular function is NOT regulated by protein-protein interactions?
DNA replication
What do online tools like STRING primarily analyze?
Protein-protein interactions
What is the primary function of Gene Ontology (GO)?
Describing knowledge of three aspects of the biology of the gene/protein
Which platform is used for Database for Annotation, Visualization and Integrated Discovery (DAVID) analysis?
What type of data can be analyzed using DAVID?
Differentially expressed genes and proteins
Which type of interactions are involved in protein-protein interactions (PPIs)?
Electrostatic forces, hydrogen bonding, and the hydrophobic effect
What is the main purpose of molecular docking in the drug discovery process?
Modeling the interaction between a small molecule and a protein
Which of the following is a ligand database used in docking programs?
PubChem
What are examples of protein structure validation programs?
PROCHECK, ERRAT, Rampage
What does the Human Reference Interactome (HuRI) map chart?
Interactions between human proteins
Which of the following is a type of cellular function regulated by protein-protein interactions?
Muscle contraction
What is the main purpose of the Gene Ontology (GO)?
Describing knowledge of the biology of genes/proteins
What type of data can be analyzed using DAVID?
Differentially expressed genes and proteins
What is the function of the online tool STRING in protein-protein interaction analysis?
Analyzing known and predicted protein interactions
What types of cellular functions are regulated by protein-protein interactions?
Electron transfer, signal transduction, cell metabolism, muscle contraction, membrane transport
What is the main purpose of the Human Reference Interactome (HuRI) map?
Charting interactions between human proteins
What do functional analysis methods help us to gain insight about?
The biology underlying a list of genes
What do online tools like STRING primarily analyze?
Known and predicted protein interactions
Which platform is used for Database for Annotation, Visualization and Integrated Discovery (DAVID) analysis?
DAVID (https://david.ncifcrf.gov/)
What type of questions can be answered using functional analysis methods?
Impact of a viral infection on a cell, impact of a drug treatment/stress/protein knockdown, function of differentially expressed genes/proteins in a disease condition, signaling pathways affected by a disease/stress or viral infection.
Explore protein structure validation programs such as PROCHECK, ERRAT, Rampage, WHATIF, ProQ, and SuperPose. Learn about molecular docking simulation and its role in the drug discovery process, modeling the interaction between small molecules and proteins, and the importance of knowing binding pockets for improved efficiency.
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