5 Questions
Which of the following is an example of a ligand in complexation?
Water
What is complexation in physical pharmaceutics?
The process of covalent or non-covalent interactions between two or more compounds
What are the altered physical and chemical properties of the complexing species after complexation?
Solubility, stability, partition co-efficient, energy absorption, energy emission, conductance
What type of bonds are involved in complex formation?
Covalent and coordinate covalent
What is a coordination complex in complexation?
The product of a Lewis acid-base reaction where ligands bond to a central metal atom by coordinate covalent bonds
Study Notes
Complexation in Physical Pharmaceutics
- A ligand is a molecule or ion that donates one or more electron pairs to a central atom or ion to form a complex.
Complexation Definition
- Complexation is a process in which a central atom or ion, typically a metal ion, is bonded to one or more ligands, resulting in a complex species.
Altered Properties of Complexing Species
- After complexation, the physical and chemical properties of the complexing species are altered, including changes in solubility, stability, and reactivity.
Bonds Involved in Complex Formation
- Coordination bonds, also known as dative covalent bonds, are involved in complex formation, where the ligand donates one or more electron pairs to the central atom or ion.
Coordination Complex
- A coordination complex, also known as a complex ion, is a complex species formed by the coordination of one or more ligands to a central atom or ion, resulting in a stable, three-dimensional structure.
Test your knowledge of complexation and protein binding in physical pharmaceutics with this quiz. Explore the process of complex formation and the interactions between drug molecules and ligands.
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