5 Questions
Which pathway of the complement system can be activated by the presence of antigen-antibody complexes?
Classical Pathway
Which protein is enzymatically cleaved into a large fragment C3b and a small fragment C3a (anaphylatoxin) in the complement system?
C3
Which complement pathway is activated by binding to activating surfaces such as bacteria?
Alternative Pathway
Which protein is involved in the MBL pathway and functions as an enzyme to cleave MBL-associated serine proteases (MASPs)?
MASP-1
Which component of the complement system forms the membrane attack complex (MAC) that leads to lysis of pathogens?
C5b
Study Notes
Complement System Activation
- Antigen-antibody complexes can activate the classical pathway.
C3 Protein in Complement System
- The C3 protein is enzymatically cleaved into a large fragment C3b and a small fragment C3a (anaphylatoxin).
Lectin Pathway Activation
- The lectin pathway is activated by binding to activating surfaces such as bacteria.
MBL Pathway Enzyme
- The MASP (MBL-associated serine protease) is involved in the MBL pathway and functions as an enzyme to cleave MBL-associated serine proteases.
Membrane Attack Complex (MAC)
- The C5-9 complex forms the membrane attack complex (MAC) that leads to lysis of pathogens.
Test your knowledge of the complement system pathways with this quiz. Identify key components and understand how the classical, alternative, and lectin pathways function.
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