Complement System Functions Quiz
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Questions and Answers

What is the main function of opsonization of microbes by Complement components?

  • Inducing inflammation
  • Increasing vascular permeability
  • Coactivating B cells
  • Inducing phagocytosis (correct)
  • Which complement component is responsible for increasing extravasation of plasma proteins and monocytes/neutrophils?

  • C3a
  • Factor I
  • C4a
  • C5a (correct)
  • What is the role of Factor H in the regulation of Complement?

  • Binds to C3b and helps Factor I cleave C3b (correct)
  • Binds to C3b or C4b and disassociates C3 convertase
  • Dissociates C1s and C1r from C1q
  • Binds to CR2 on B cells
  • Which pathway of the complement system involves triggering events that lead to the same terminal pathway?

    <p>Alternative pathway</p> Signup and view all the answers

    What is the complement component that binds to an antigen-antibody complex in the classical pathway?

    <p>C1</p> Signup and view all the answers

    Which complement proteins can fix complement proteins in the classical pathway?

    <p>IgM and IgG</p> Signup and view all the answers

    In the lectin pathway, what molecule binds to mannan present on the surface of microbes?

    <p>MBL (mannose-binding lectin)</p> Signup and view all the answers

    What is the function of mast cells and basophils?

    <p>Causing immediate hypersensitivity reactions</p> Signup and view all the answers

    How are natural killer (NK) cells activated?

    <p>By IL-12 IFNα/β from virus-infected cells</p> Signup and view all the answers

    What is the role of inhibitory receptors in NK cell activation?

    <p>Recognizing Class I MHC molecules to inhibit killing</p> Signup and view all the answers

    What do neutrophils primarily mediate in the inflammatory response?

    <p>Phagocytosis</p> Signup and view all the answers

    Which antibody is designed to protect from helminth but is remembered for allergic reactions?

    <p>IgE</p> Signup and view all the answers

    Which antibody is the largest and the first antibody produced?

    <p>IgM</p> Signup and view all the answers

    Which antibody is most commonly found in blood and other body fluids?

    <p>IgG</p> Signup and view all the answers

    Which antibody is a marker used to define mature B cells?

    <p>IgA</p> Signup and view all the answers

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