Complement System Functions Quiz

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What is the main function of opsonization of microbes by Complement components?

Inducing inflammation

Increasing vascular permeability

Coactivating B cells

Inducing phagocytosis (correct)

Which complement component is responsible for increasing extravasation of plasma proteins and monocytes/neutrophils?

C3a

Factor I

C4a

C5a (correct)

What is the role of Factor H in the regulation of Complement?

Binds to C3b and helps Factor I cleave C3b (correct)

Binds to C3b or C4b and disassociates C3 convertase

Dissociates C1s and C1r from C1q

Binds to CR2 on B cells

Which pathway of the complement system involves triggering events that lead to the same terminal pathway?

Alternative pathway Signup and view all the answers

What is the complement component that binds to an antigen-antibody complex in the classical pathway?

C1 Signup and view all the answers

Which complement proteins can fix complement proteins in the classical pathway?

IgM and IgG Signup and view all the answers

In the lectin pathway, what molecule binds to mannan present on the surface of microbes?

MBL (mannose-binding lectin) Signup and view all the answers

What is the function of mast cells and basophils?

Causing immediate hypersensitivity reactions Signup and view all the answers

How are natural killer (NK) cells activated?

By IL-12 IFNα/β from virus-infected cells Signup and view all the answers

What is the role of inhibitory receptors in NK cell activation?

Recognizing Class I MHC molecules to inhibit killing Signup and view all the answers

What do neutrophils primarily mediate in the inflammatory response?

Phagocytosis Signup and view all the answers

Which antibody is designed to protect from helminth but is remembered for allergic reactions?

IgE Signup and view all the answers

Which antibody is the largest and the first antibody produced?

IgM Signup and view all the answers

Which antibody is most commonly found in blood and other body fluids?

IgG Signup and view all the answers

Which antibody is a marker used to define mature B cells?

IgA Signup and view all the answers

Complement System Functions Quiz

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