Comparing the Duration of Action of Diazepam and Oxazepam

Diazepam has a lower lipid solubility compared to oxazepam

Diazepam is metabolized into active metabolites with long half-lives (correct)

Oxazepam is excreted through the kidneys more slowly than diazepam

Oxazepam has a higher binding affinity to plasma proteins

Higher plasma protein binding of diazepam

Lower lipophilicity of diazepam

Formation of active metabolites with long half-lives (correct)

Rapid renal excretion of diazepam

Metabolism into long-acting active compounds (correct)

Lower volume of distribution

Faster renal clearance

Stronger interaction with plasma proteins

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