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Questions and Answers
Why does the duration of action of diazepam exceed that of oxazepam?
Why does the duration of action of diazepam exceed that of oxazepam?
- Diazepam has a lower lipid solubility compared to oxazepam
- Diazepam is metabolized into active metabolites with long half-lives (correct)
- Oxazepam is excreted through the kidneys more slowly than diazepam
- Oxazepam has a higher binding affinity to plasma proteins
Which factor contributes to the extended duration of action of diazepam compared to oxazepam?
Which factor contributes to the extended duration of action of diazepam compared to oxazepam?
- Higher plasma protein binding of diazepam
- Lower lipophilicity of diazepam
- Formation of active metabolites with long half-lives (correct)
- Rapid renal excretion of diazepam
What mechanism primarily accounts for the longer duration of action of diazepam in comparison to oxazepam?
What mechanism primarily accounts for the longer duration of action of diazepam in comparison to oxazepam?
- Metabolism into long-acting active compounds (correct)
- Lower volume of distribution
- Faster renal clearance
- Stronger interaction with plasma proteins
Which of the following is a common side effect of angiotensin-converting enzyme (ACE) inhibitors?
Which of the following is a common side effect of angiotensin-converting enzyme (ACE) inhibitors?
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What is the primary mechanism of action of calcium channel blockers in treating hypertension?
What is the primary mechanism of action of calcium channel blockers in treating hypertension?
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Which class of antihypertensive medications is contraindicated in patients with a history of angioedema?
Which class of antihypertensive medications is contraindicated in patients with a history of angioedema?
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