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Questions and Answers
What type of endothelium lines the blood capillary beds in the liver lobule?
What type of endothelium lines the blood capillary beds in the liver lobule?
Where is bile produced within the liver structure?
Where is bile produced within the liver structure?
Which of the following ducts is commonly found in the dog?
Which of the following ducts is commonly found in the dog?
What is the main function of the central vein in a liver lobule?
What is the main function of the central vein in a liver lobule?
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In which animal does the pancreatic duct typically open alongside the bile duct?
In which animal does the pancreatic duct typically open alongside the bile duct?
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What connects the interlobular ducts in the liver?
What connects the interlobular ducts in the liver?
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What is one of the primary functions of the liver?
What is one of the primary functions of the liver?
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Which type of cells in the liver are involved in immune function?
Which type of cells in the liver are involved in immune function?
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Where is the gall bladder located in relation to the liver?
Where is the gall bladder located in relation to the liver?
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What is a significant difference regarding the gall bladder among some species?
What is a significant difference regarding the gall bladder among some species?
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What substance does the liver synthesize that is crucial for blood clotting?
What substance does the liver synthesize that is crucial for blood clotting?
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Which vitamin is stored in the liver?
Which vitamin is stored in the liver?
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What can be identified as a major metabolic function of the liver?
What can be identified as a major metabolic function of the liver?
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In which location of the abdominal cavity does the liver primarily reside?
In which location of the abdominal cavity does the liver primarily reside?
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What is the term for the structural units of the liver?
What is the term for the structural units of the liver?
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What is the strongly convex surface of the liver that faces the diaphragm called?
What is the strongly convex surface of the liver that faces the diaphragm called?
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Which surface of the liver is concave and lies against the stomach and duodenum?
Which surface of the liver is concave and lies against the stomach and duodenum?
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The porta of the liver is also known as what?
The porta of the liver is also known as what?
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What anatomical structure is located cranial to the liver?
What anatomical structure is located cranial to the liver?
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Which lobe of the liver is not present in pigs according to the lobulation description?
Which lobe of the liver is not present in pigs according to the lobulation description?
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In dogs, which organ is located to the left of the liver?
In dogs, which organ is located to the left of the liver?
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Which lobe of the liver is present in ruminants but not in the horse?
Which lobe of the liver is present in ruminants but not in the horse?
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Which of the following statements regarding the liver in dogs is incorrect?
Which of the following statements regarding the liver in dogs is incorrect?
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Which organ does the caudal part of the liver cover in dogs?
Which organ does the caudal part of the liver cover in dogs?
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Which lobe is present in all domestic species mentioned?
Which lobe is present in all domestic species mentioned?
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Where does the liver lie in horses?
Where does the liver lie in horses?
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What is the location of the liver biopsy site at the 12th ICS in horses?
What is the location of the liver biopsy site at the 12th ICS in horses?
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How is the rabbit liver divided?
How is the rabbit liver divided?
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Which lobe could potentially contribute to liver torsion in rabbits?
Which lobe could potentially contribute to liver torsion in rabbits?
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What is true about the cow liver's position?
What is true about the cow liver's position?
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What structure lies at the 10th ICS in cows?
What structure lies at the 10th ICS in cows?
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What is the main function of peritoneal folds?
What is the main function of peritoneal folds?
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Which ligament is a remnant of the umbilical vein?
Which ligament is a remnant of the umbilical vein?
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What type of covering does the liver have?
What type of covering does the liver have?
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What is the purpose of the falciform ligament?
What is the purpose of the falciform ligament?
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What is the primary role of ligaments in relation to the liver?
What is the primary role of ligaments in relation to the liver?
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What major vein supplies 60-70% of the blood flow to the liver?
What major vein supplies 60-70% of the blood flow to the liver?
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What structures form the portal triad in the hepatic lobule?
What structures form the portal triad in the hepatic lobule?
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Which nerve fibers innervate the liver?
Which nerve fibers innervate the liver?
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What is the shape of the hepatic lobule?
What is the shape of the hepatic lobule?
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Which abdominal organs does the hepatic portal vein collect blood from?
Which abdominal organs does the hepatic portal vein collect blood from?
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Which ligaments are involved in connecting the liver to the diaphragm?
Which ligaments are involved in connecting the liver to the diaphragm?
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What type of blood does the hepatic artery carry to the liver?
What type of blood does the hepatic artery carry to the liver?
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What happens to blood from the portal vein and hepatic artery in the liver?
What happens to blood from the portal vein and hepatic artery in the liver?
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How do vagal axons reach the liver?
How do vagal axons reach the liver?
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Study Notes
Digestive System - Comparative Anatomy of the Liver and Pancreas
- Objectives: The presentation outlines learning objectives related to the comparative anatomy of the liver and pancreas in domestic species. These objectives include topography, lobulation, microscopic structure, blood supply, venous drainage, and innervation.
Liver Functions
- Detoxification and excretion: The liver removes waste products from the blood.
- Secretion (Bile): The liver produces bile, essential for digestion
- Storage: The liver stores lipids, vitamins (A and B), and glycogen.
- Synthesis: The liver synthesizes albumin, clotting factors, and globulins.
- Metabolism: The liver plays a role in protein, carbohydrate, and lipid metabolism.
- Immune function: Kupffer cells within the liver are part of the immune system.
Species Comparison (Liver)
- Location: The liver is the largest abdominal gland, positioned caudal to the diaphragm, typically on the right-hand side of the abdominal cavity in most species, and often entirely moved to the right in ruminants.
- Gall Bladder: The gall bladder is located between the right medial and quadrate lobes of the liver. Some species, notably horses and rats, lack a gall bladder in the fossa.
- Surface Features: The liver has a strongly convex surface facing the diaphragm (parietal/ diaphragmatic surface); the opposing, concave surface faces the internal organs (visceral surface). The porta of the liver is where major vessels and the bile duct enter or leave the liver.
Liver Lobes
- Lobulation: Different domestic species (dogs, pigs, ruminants, horses, rabbits, sheep, cows) exhibit varying degrees of visible discrete liver lobes.
Liver Topography (e.g., Dog and Horse)
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Dog: The liver is related to the stomach, spleen, pancreas, kidney, duodenum, and the greater omentum. It reaches the umbilical region and extends down to the 13th thoracic vertebra.
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Horse: Found entirely within the ribcage and positioned across the diaphragm. Its caudal margin reaches the 15th intercostal space.
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Rabbit: The liver has five lobes and a deep cleft that divides the lobes into right and left halves. A caudate lobe is often present, attached near the porta.
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Cow: The liver extends dorsally about as far as the last rib. Liver biopsy typically samples the 10th intercostal space (ICS)
Liver Attachments
- Serosa (visceral peritoneum): The liver is covered with serosa and has a thin connective tissue capsule.
- Ligaments: The falciform ligament connects the liver to the diaphragm and ventral abdominal wall. The round ligament is a remnant of the umbilical vein. The lesser omentum (hepatoduodenal and hepatogastric ligaments) are significant for attaching the liver.
Liver Blood Supply
- Hepatic Portal Vein: Carries nutrient-rich venous blood from unpaired abdominal organs.
- Hepatic Artery: Carries oxygenated blood.
- Blood Flow: Blood from the portal vein and hepatic artery intermix in hepatic sinusoids before reaching the central veins, which eventually drain into the caudal vena cava.
Liver Innervation
- Nerves: The liver receives sympathetic and parasympathetic innervation, with fibres from the vagal trunk and sympathetic axons from the celiac plexus/ganglion.
- Vagal Pathway: Vagal axons pass through the diaphragm with the esophagus to reach the abdomen and innervation target.
Hepatic Lobule
- Structure: Fundamental unit; hexagonal shaped. Contains a triad (portal venule, small bile duct, and hepatic arteriole) at each corner.
- Blood Flow: Arterioles and venules empty blood into the lobule's spongy tissue, where blood flows through capillary beds known as liver sinusoids. A central vein drains the lobule.
Bile and Bile Duct
- Production: Bile is produced by hepatocytes (liver cells).
- Discharge: Released into bile canaliculi.
- Formation: Canaliculi merge to form interlobular ducts, then hepatic ducts, which eventually connect to the cystic duct and the bile duct.
Pancreas
- Location: Dorsal part of the abdominal cavity, often abutting the stomach and liver. Typically comprises two connected lobes.
- Blood Supply: Coeliac and cranial mesenteric arteries supply blood.
- Ducts: Pancreas has both a major (pancreatic) and a minor (accessory) duct; in some species (sheep, pig) only the major duct is present.
- Location (duodenal relation): The body of the pancreas is situated near the pylorus (opening to the duodenum).
Pancreatic and Bile Ducts (Comparative)
- Species variation: Pancreatic and bile duct arrangements vary between species (e.g., horse, dog, cat, pig, sheep, cow). Some species may have a common opening into the duodenum, while others merge before the duct empties.
Supportive Reading
- Recommended texts: Specific veterinary anatomy text resources are listed for further study.
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Description
This quiz explores the comparative anatomy of the liver and pancreas across domestic species. Topics include the functions of the liver, such as detoxification and metabolism, as well as the topographical and microscopic differences between species. Test your knowledge on these vital organs!