Common Side Effects and Lipoprotein Apheresis
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Questions and Answers

What is the effect of ezetimibe on LDL-C levels when added to diet?

  • No effect
  • Decrease by 15-20% (correct)
  • Increase by 10%
  • Increase by 15-20%

In patients with primary hypercholesterolemia where initial statin therapy is contraindicated, what is the recommended treatment?

  • Ezetimibe plus statin therapy
  • Fibrates
  • Lomitapide
  • Ezetimibe monotherapy (correct)

What is the recommended daily dosage of ezetimibe?

  • 20 mg
  • 10 mg (correct)
  • 5 mg
  • 15 mg

Which group of drugs is thought to act by binding to peroxisome proliferator-activated receptor α on hepatocytes?

<p>Fibrates (B)</p> Signup and view all the answers

What effect does ezetimibe have when added to a statin therapy?

<p>Lowers LDL-C by approximately 20% (D)</p> Signup and view all the answers

In which patients is ezetimibe contraindicated when co-administered with a statin?

<p>Patients with active liver disease (C)</p> Signup and view all the answers

What is the maximum daily dose for Lomitapide?

<p>60 mg (D)</p> Signup and view all the answers

Which of the following conditions is a contraindication for Lomitapide use?

<p>Inflammatory bowel disease (C)</p> Signup and view all the answers

What adverse event is mainly associated with the use of Lomitapide?

<p>Diarrhea (D)</p> Signup and view all the answers

For which condition should Lomitapide be used according to the text?

<p>Homozygous familial hypercholesterolemia (B)</p> Signup and view all the answers

What enzyme does Lomitapide inhibit?

<p>Microsomal triglyceride transfer protein (D)</p> Signup and view all the answers

What is a possible effect of Lomitapide treatment on liver function tests according to the text?

<p>Increased alanine transaminase levels (A)</p> Signup and view all the answers

What is the main purpose of lipoprotein apheresis treatment?

<p>To remove LDL-C, Lp(a), and triglycerides from the plasma. (C)</p> Signup and view all the answers

Why is the effect of lipoprotein apheresis considered transient?

<p>Because it only temporarily lowers LDL-C. (D)</p> Signup and view all the answers

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