Commensals vs Infections
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Questions and Answers

Which of the following best describes commensal organisms?

  • Microbes that cause disease in the host
  • Microbes that adhere to body surfaces and form stable polymicrobial communities (correct)
  • Microbes that damage host tissues
  • Microbes that compete with normal microflora for resources
  • What must a microbe do to act as a pathogen?

  • Find an appropriate niche within a host
  • Compete with normal microflora
  • Express genes that cause disease
  • All of the above (correct)
  • What is the term for the ability of a microbe to damage a host?

  • Toxicity
  • Pathogenicity (correct)
  • Adhesion
  • Virulence
  • Which of the following are considered virulence factors?

    <p>Adhesins, toxins, and capsules</p> Signup and view all the answers

    What is the main cause of tissue damage in bacterial infections?

    <p>Inflammatory response</p> Signup and view all the answers

    How do bacteria enter the body during infection?

    <p>All of the above</p> Signup and view all the answers

    What are the possible outcomes when bacteria enter where they shouldn't?

    <p>Quick clearance or clinical disease</p> Signup and view all the answers

    Which cells are involved in the response to bacterial infections?

    <p>Neutrophils and macrophages</p> Signup and view all the answers

    What is the term for the relative capacity of a pathogen to damage a host?

    <p>Virulence</p> Signup and view all the answers

    What are the clinical consequences of bacterial infection?

    <p>Tissue damage and immune response</p> Signup and view all the answers

    Which type of neutrophils increase in a regenerative left shift?

    <p>Segmented neutrophils</p> Signup and view all the answers

    What change in neutrophil morphology is seen in a degenerative left shift?

    <p>Increase in immature neutrophils</p> Signup and view all the answers

    What can cause foamy cytoplasm in neutrophils?

    <p>Toxic change</p> Signup and view all the answers

    What are Döhle bodies in neutrophils?

    <p>Focal blue-grey cytoplasmic structures</p> Signup and view all the answers

    In which of the following conditions can Döhle bodies be a normal finding?

    <p>Healthy cats</p> Signup and view all the answers

    What is a possible cause of coagulopathy in sepsis?

    <p>Stimulation of prothrombotic factors</p> Signup and view all the answers

    Which of the following is a possible reason for a person to be a carrier of a bacterial infection?

    <p>They have a subclinical infection</p> Signup and view all the answers

    What are some pathognomonic clinical presentations of bacterial infection?

    <p>Both systemic and localized inflammatory responses</p> Signup and view all the answers

    What type of inflammation is associated with the presence of neutrophils and acute inflammation?

    <p>Pus formation</p> Signup and view all the answers

    What are some cardiovascular consequences of bacterial infection?

    <p>Both congested mucous membranes and toxic line in gums</p> Signup and view all the answers

    What are some clinical pathology findings associated with inflammation in the blood?

    <p>All of the above</p> Signup and view all the answers

    What is the difference between bacteraemia and septicaemia?

    <p>Bacteraemia is the presence of bacteria in the blood, while septicaemia is the replication of bacteria in the blood</p> Signup and view all the answers

    What is the typical neutrophil concentration in circulation for a dog?

    <p>3.0-11 x 103/ul</p> Signup and view all the answers

    In which species is neutropenia typical in inflammation regardless of severity?

    <p>Cow</p> Signup and view all the answers

    What are the three steps for cells to leave blood vessels?

    <p>Marginalisation, adhesion, migration</p> Signup and view all the answers

    Which factors can produce a shift from the marginal to circulating pool of cells?

    <p>Epinephrine, glucocorticoids, infection</p> Signup and view all the answers

    What are the potential reasons for a person to be a carrier of a bacterial infection?

    <p>Subclinical infection or latent infection</p> Signup and view all the answers

    What are the clinical presentations of bacterial infection?

    <p>Inflammatory response, systemic and local symptoms, pus formation, granulomas</p> Signup and view all the answers

    What are the cardiovascular consequences of bacterial infection?

    <p>Congested mucous membranes, toxic line in gums, septicaemia</p> Signup and view all the answers

    What are the clinical pathology findings associated with inflammation in the blood?

    <p>Changes in neutrophil count, acute phase proteins, acid base and coagulation abnormalities</p> Signup and view all the answers

    What are the three steps for cells to leave blood vessels?

    <p>Marginalisation, adhesion, migration</p> Signup and view all the answers

    What are some possible causes of neutrophil toxic change in blood samples?

    <p>Rapid neuropoiesis, severe bacterial infection, injection of G-CSF</p> Signup and view all the answers

    What are Döhle bodies and when can they be seen in blood samples?

    <p>Döhle bodies are focal blue-grey cytoplasmic structures (RER/RNA) that can be seen in some healthy cats.</p> Signup and view all the answers

    What are some possible causes of asynchronous nuclear maturation in neutrophils?

    <p>Bacterial infections (Ehrlichia, Anaplasma, anthrax), viral infections (canine distemper), protozoal infections (Toxoplasma, Hepatozoon), fungal infections (Histoplasma), and hereditary/metabolic disorders (Chediak-Higashi, Birman cat anomaly, mucopolysaccharidosis).</p> Signup and view all the answers

    What is the main cause of coagulopathy in sepsis?

    <p>Inflammation, which is a procoagulant state that can lead to microthrombi formation, lower platelet counts, and consumption of coagulation factors.</p> Signup and view all the answers

    What is the difference between degenerate and non-degenerate neutrophils in tissue samples?

    <p>Degenerate neutrophils have finely granular nuclear chromatin but are in 'segments,' while non-degenerate neutrophils have dispersed organelles, persistent cytoplasmic RNA, and diffuse cytoplasmic basophilia.</p> Signup and view all the answers

    Define commensal organisms and explain their role in the human body.

    <p>Commensal organisms are microorganisms that colonize the human body without causing harm. They form stable communities known as normal microflora, which are present on the skin and in various body cavities. These organisms play a beneficial role in maintaining health by competing with potential pathogens and contributing to immune system development.</p> Signup and view all the answers

    What are the requirements for a microbe to act as a pathogen?

    <p>For a microbe to act as a pathogen, it must find an appropriate niche within a host, compete with the normal microflora, evade or overcome host defenses, and express genes that encode factors causing disease.</p> Signup and view all the answers

    Explain the concept of pathogenicity and virulence.

    <p>Pathogenicity refers to the ability of a microbe to cause damage to a host. Virulence, on the other hand, refers to the relative capacity of a pathogen to cause damage. Virulence factors, such as adhesins, toxins, and capsules, are bacterial traits that confer pathogenicity.</p> Signup and view all the answers

    Describe the different ways bacteria can invade the human body.

    <p>Bacteria can invade the human body through different mechanisms. They can enter between cells of the epithelium (paracellular), crack open cells to gain entry, or take advantage of widened gaps during an inflammatory response. Some bacteria can also enter cells in the body.</p> Signup and view all the answers

    What are the possible outcomes when bacteria enter where they shouldn't?

    <p>When bacteria enter areas where they shouldn't, they can be quickly cleared by the immune system. However, if they are not cleared, clinical disease can occur, which may manifest as acute, subacute, or chronic infections.</p> Signup and view all the answers

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