14 Questions
Which lifestyle interventions are considered the most effective therapeutic approaches for PCOS treatment?
Exercise and weight reduction
Why is Spironolactone used in cases where some women cannot tolerate other medicines?
Its effectiveness in reducing hirsuteness
What is a reason why Cyproterone is not recommended for patients without reliable contraception?
It has a similar effect on reducing hirsuteness to finasteride
Which type of treatments have shown promising results in studies related to PCOS pathophysiology?
Insulin sensitizing and anti-androgenic treatments
What was the outcome of the study on combined rosiglitazone and flutamide treatment for PCOS?
No further benefit compared to using either drug alone
Why are androgen lowering agents for PCOS considered off-label medications?
They have not been approved by the US FDA for this specific use
What is the primary reason oral contraceptives are often considered first-line therapy for women with PCOS?
To protect the endometrium from hyperplasia
What effect have statins been investigated for in relation to PCOS?
Decreasing hirsutism scores
Which medication has shown a 30% reduction in hirsutism scores but is not widely used due to teratogenicity concerns?
Finasteride
Which group of medications has been shown to have positive effects on PCOS but only in patients with abnormal glucose metabolism?
Insulin sensitizers
What is the key factor in PCOS that contributes to increased androgen secretion from the ovaries?
High insulin levels and reduced sex hormone binding globulin production in the liver
How do oral contraceptives alleviate symptoms of PCOS like acne and hirsutism?
By reducing free androgens
What is the primary benefit of combining metformin with oral contraceptives for PCOS treatment?
To improve menstrual regulation and alleviate hirsutism
How does metformin benefit PCOS patients who are unable to induce ovulation alone?
By improving granulosa cell function and correcting abnormalities
Learn about the multifaceted approach used in treating PCOS, including lifestyle interventions, pharmacological treatments, and alternative hormonal treatments. Explore the effectiveness of combining therapies to manage clinical and biological changes associated with PCOS.
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