Coloring Agents in Pharmaceuticals Quiz & Flashcards

What is the maximum amount of flavoring agents that can be used in chewable tablets?

Which sweetening agent is sweeter than sucrose but can give a bitter aftertaste and is considered to be carcinogenic?

What do adsorbents do in the production of tablets?

Which polymer is used in tablets to retard dissolution?

What is the role of wetting agents in tablets containing poorly soluble drugs?

What is the main disadvantage of using sucrose as a sweetening agent?

What is the first step in the wet granulation process for tablet manufacture?

Which process can be used for tablet production without initial granulation?

What is the purpose of using sodium carboxymethylcellulose in tablet production through direct compression?

When is the disintegrant added in the dry granulation process?

What is the method of choice for tablet production with powder moisture or thermosensitive ingredients?

Which excipient is typically included to provide flowability and cohesive features to the powder mixture for tablet production through direct compression?

What is the main advantage of the direct compression process for tablet manufacture?

Flavoring Agents in Chewable Tablets

Maximum allowable amount of flavoring agents in chewable tablets is typically regulated, but specific limits may vary by region.

Sweetening Agents

Aspartame is a sweetening agent that is sweeter than sucrose, known for causing a bitter aftertaste and considered to be potentially carcinogenic.

Role of Adsorbents

Adsorbents are added in tablet production to absorb moisture, preventing degradation and ensuring stability of the final product.

Dissolution-Retarding Polymers

Hydroxypropyl methylcellulose (HPMC) is commonly used to retard dissolution in tablets, controlling the release rate of the active ingredient.

Wetting Agents in Poorly Soluble Drugs

Wetting agents aid solubility and improve the dissolution of poorly soluble drugs in tablet formulations.

Disadvantage of Sucrose

Sucrose can lead to dental caries and may cause fluctuations in blood glucose levels, making it less desirable for some formulations.

First Step in Wet Granulation

The initial step involves the mixing of active ingredients with a binder to form a wet mass.

Tablet Production without Granulation

The direct compression method enables tablet production without the need for initial granulation, simplifying the process.

Purpose of Sodium Carboxymethylcellulose

Sodium carboxymethylcellulose serves as a binder and disintegrant in direct compression tablet production, enhancing tablet integrity and dissolution.

Disintegrant Addition in Dry Granulation

In the dry granulation process, disintegrants are typically added after the granules are formed, ensuring effective decomposition of the tablet upon ingestion.

Method for Moisture or Thermosensitive Ingredients

The direct compression process is the preferred method for tablet production when dealing with moisture-sensitive or thermosensitive ingredients, as it avoids heat and excessive moisture exposure.

Flowability and Cohesion in Direct Compression

Microcrystalline cellulose is commonly included to enhance flowability and cohesive properties of the powder mixture for direct compression tablet production.

Advantage of Direct Compression

Direct compression offers a faster manufacturing process and reduces the need for additional processing steps, making it more efficient and cost-effective.

This quiz covers the identification and use of coloring agents in off-color drugs, the production of elegant products, and the characteristics of flavoring and sweetening agents in pharmaceuticals. Topics also include the disadvantages and safety considerations of various sweetening agents.