Coagulation and Hemostasis Quiz
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Questions and Answers

Primary hemostasis involves the activation of platelets and the blood vessels themselves.

True (A)

The intrinsic pathway of the coagulation cascade is triggered by tissue injury.

False (B)

The end products of fibrinolysis are fibrin degradation products (FDPs).

True (A)

Vitamin K is necessary for the activation of factors III, VII, IX, and X in the coagulation cascade.

<p>False (B)</p> Signup and view all the answers

Tertiary hemostasis is responsible for the stabilization and regulation of clot size.

<p>True (A)</p> Signup and view all the answers

Normal clotting can take as long as 10-15 minutes to initiate.

<p>False (B)</p> Signup and view all the answers

Platelets release vasoactive compounds to induce vasoconstriction during primary hemostasis.

<p>True (A)</p> Signup and view all the answers

Antithrombin III and Protein C are the only anticoagulants involved in the coagulation cascade.

<p>False (B)</p> Signup and view all the answers

Thrombosis can occur even when a blood vessel is not injured.

<p>True (A)</p> Signup and view all the answers

Massive pulmonary embolism can lead to hypoxemia and shock.

<p>True (A)</p> Signup and view all the answers

In the Ivy method for bleeding time, the blood pressure cuff is inflated to 60 mM Hg.

<p>False (B)</p> Signup and view all the answers

The time taken for bleeding to stop in the Ivy method is typically between 10-15 minutes.

<p>False (B)</p> Signup and view all the answers

An embolus is a piece of blood clot that does not travel through the bloodstream.

<p>False (B)</p> Signup and view all the answers

The Duke's method involves a standardized puncture of the arm.

<p>False (B)</p> Signup and view all the answers

Thrombosis in an artery can lead to ischemic necrosis of the supplied tissue.

<p>True (A)</p> Signup and view all the answers

The bleeding time is measured from the time the stab wound is made until bleeding begins.

<p>False (B)</p> Signup and view all the answers

Cessation of bleeding is primarily due to the formation of a clot involving fibrin.

<p>False (B)</p> Signup and view all the answers

The normal range for bleeding time is 1-2 minutes.

<p>False (B)</p> Signup and view all the answers

A prolonged prothrombin time indicates a deficiency in coagulation factors I, II, V, VII, or X.

<p>True (A)</p> Signup and view all the answers

Activated partial thromboplastin time (aPTT) normal range is between 20 to 30 seconds.

<p>False (B)</p> Signup and view all the answers

Thrombocytopenia can lead to a prolonged bleeding time.

<p>True (A)</p> Signup and view all the answers

Vitamin K deficiency is likely to prolong clotting time.

<p>True (A)</p> Signup and view all the answers

The normal clotting time for whole blood is less than 10 minutes.

<p>False (B)</p> Signup and view all the answers

A normal International Normalised Ratio (INR) is considered to be from 0.5 to 1.0.

<p>False (B)</p> Signup and view all the answers

Flashcards

Hemostasis

The process that stops bleeding from a damaged blood vessel

Primary Hemostasis

The initial stage of hemostasis, involving platelets and blood vessels to form a plug

Secondary Hemostasis

The stage of hemostasis where clotting factors create a fibrin clot to reinforce the platelet plug.

Platelet plug

A clump of activated platelets formed to stop blood from flowing

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Clotting Factors

Proteins involved in the cascade to form a fibrin clot

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Fibrin

The insoluble protein that forms the mesh of a blood clot

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Fibrinolysis

The process that breaks down the blood clot once the damage is repaired

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Extrinsic pathway

One of the two pathways activating clotting factors, triggered by tissue injury

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Thrombosis

The formation of a blood clot inside a blood vessel, preventing normal blood flow.

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Embolism

A blood clot or other object that travels through the bloodstream and blocks a vessel.

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Blood clot

A collection of blood components that prevents excessive bleeding.

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Pulmonary embolism

A blood clot in the pulmonary artery, often leading to breathing problems.

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Bleeding time (Ivy method)

A test measuring how long it takes for bleeding to stop from a standardized puncture.

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Bleeding time (Duke's method)

A test measuring bleeding time from a standardized earlobe or fingertip puncture.

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Ischemic necrosis

Death of tissue due to lack of blood flow.

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Embolus

A detached piece of a blood clot (thrombus) that travels through the circulatory system.

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Bleeding Time

The time it takes for bleeding to stop, usually due to platelet plug formation and capillary spasm, not clotting.

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Prolonged Bleeding Time

Bleeding time significantly longer than normal, indicating issues with platelets, vessel function, or von Willebrand's disease.

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Coagulation Time

The time it takes for blood to clot completely under specific lab conditions.

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Prolonged Coagulation Time

Coagulation time exceeding the normal range, suggesting deficiencies in clotting factors (e.g., hemophilia).

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Prothrombin Time (PT)

The time it takes for fibrin strands to form, assessing the extrinsic and common clotting pathways.

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International Normalized Ratio (INR)

A standardized measure of PT, comparing a patient's PT to a lab's control PT.

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Activated Partial Thromboplastin Time (aPTT)

Time for clot formation after adding calcium, phospholipids, and kaolin. It measures the intrinsic and common pathways of coagulation.

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Haemostatic plug

A clot that stops bleeding from a damaged blood vessel, dependent on platelets and their ability to adhere and aggregate.

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