Coagulación de la Sangre: Cascada de Coagulación

Study Notes

Coagulation Cascade

Overview

The coagulation cascade is a series of complex biochemical reactions that leads to the formation of a blood clot
It involves the activation of multiple clotting factors, which ultimately results in the formation of fibrin, a protein that forms the clot

Coagulation Pathways

Extrinsic Pathway
- Initiated by tissue factor (TF) exposure
- Involves factors VII, IX, X, and V
- Activates factor X, which leads to the formation of thrombin
Intrinsic Pathway
- Initiated by collagen exposure or blood vessel damage
- Involves factors XII, XI, IX, and VIII
- Activates factor X, which leads to the formation of thrombin
Common Pathway
- Shared by both extrinsic and intrinsic pathways
- Involves factors X, V, and II (prothrombin)
- Results in the formation of thrombin, which converts fibrinogen to fibrin

Coagulation Factors

Factor VII: Activates factor X in the extrinsic pathway
Factor IX: Activates factor X in the intrinsic pathway
Factor X: Activates prothrombin (II) to form thrombin
Factor V: Activates prothrombin (II) to form thrombin
Factor II (Prothrombin): Converted to thrombin by factor X and V
Thrombin: Converts fibrinogen to fibrin, forming the blood clot
Fibrinogen: Converted to fibrin by thrombin

Regulation of Coagulation

Anticoagulant Pathways: Regulate coagulation to prevent excessive clotting
- Involves antithrombin, protein C, and protein S
Fibrinolysis: Breaks down the blood clot once it is no longer needed
- Involves plasminogen, plasmin, and tissue plasminogen activator (tPA)

Description

Aprende sobre la cascada de coagulación, incluyendo las vías extrínseca, intrínseca y común, los factores de coagulación y la regulación de la coagulación. Conoce la importancia de la formación de coágulos sanguíneos en la prevención de hemorragias.