Questions and Answers
What are some indications for Clomipramine (Anafranil)? (Select all that apply)
What is Clomipramine (Anafranil) classified as?
Antidepressant
What are the key side effects of Clomipramine (Anafranil)?
Seizures, suicidality, lethargy, sedation, weakness, aggression, blurry vision, dry mouth/eyes, vestibular disorder, arrhythmia, ECG changes, lower BP, constipation, nausea, vomiting
Which of the following are contraindications for Clomipramine (Anafranil)? (Select all that apply)
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Clomipramine (Anafranil) increases serotonin and norepinephrine.
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What nursing responsibilities are associated with Clomipramine (Anafranil)?
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What caution should be taken when prescribing Clomipramine (Anafranil)? (Select all that apply)
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Study Notes
Clomipramine (Anafranil) Overview
- Clomipramine is an antidepressant used primarily for depression, obsessive-compulsive disorder (OCD), and chronic neuro pain.
- Classified as a category C medication for pregnancy, taken orally.
Mechanism of Action
- Enhances the effects of serotonin and norepinephrine in the brain.
- Exhibits anticholinergic effects, leading to various side effects.
Side Effects
- Common side effects include seizures, lethargy, sedation, weakness, aggression, and blurred vision.
- Gastrointestinal issues: dry mouth, constipation, nausea, and vomiting.
- Cardiovascular effects: arrhythmias, ECG changes, and lower blood pressure.
- Risk of suicidality associated with use, especially in younger populations.
Nursing Responsibilities
- Monitor for interactions particularly with MAOIs, which can cause fatal consequences.
- Be cautious of blood pressure changes when combined with antihypertensives and CNS depressants.
- Recognize signs of toxicity when interacting with SSRIs and other specific medications.
Contraindications
- Not advised for individuals with a history of allergies, angle-closure glaucoma, myocardial infarction, or certain cardiac arrhythmias.
- Avoid use with MAOIs and in patients with QT prolongation or renal failure.
Cautionary Considerations
- Use cautiously in patients with a history of seizures or cardiac disease.
- Patients with prostatic hyperplasia and hyperthyroidism are at an increased risk of complications.
- Monitor for increased risk of suicide, which may stem from side effects such as weight gain, sexual dysfunction, and other systemic effects.
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Description
Test your knowledge of Clomipramine, also known as Anafranil, with these informative flashcards. Each card covers key aspects, including drug classification, indications, and side effects. Perfect for students and professionals in the field of pharmacology.
