5 Questions
What is the diagnostic criterion for circulating clonal B cells?
>5 x10e9/l persisting for >3 months
What is the significance of a CLL Score of 4 or 5?
Occurs in 92% of CLL cases
What is the characteristic surface immunophenotype of CLL?
Surface Ig weak, CD5+, CD23+, CD79b-
What is the diagnosis when >15% prolymphocytes are present?
Prolymphocytic progression of CLL
What is the term for a CD5+ monoclonal B cell lymphocytosis that is detectable on a routine FBC?
Monoclonal B cell lymphocytosis (MBL)
Diagnose and classify Chronic Lymphocytic Leukemia (CLL) based on circulating clonal B cells, immunophenotype, and CLL score. Learn to distinguish CLL from other CD5+ lymphoproliferative disorders. Understand the role of prolymphocytes and cMBL in diagnosis.
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