Clinical Trials and Stem Cells Quiz
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Questions and Answers

Why are human pluripotent stem cells (hPSCs) preferred in drug screening due to their advantages?

  • Are normal primary cell lines
  • Give rise to limited number and several types of body cells
  • Have intrinsic capability for indefinite self-renewal
  • Have the potential to differentiate into any cellular fate (correct)

    • Unlike an embryonic stem cell, a tissue stem cell...

  • Will not create terminally differentiated cells
  • Is incapable of self-renewal
  • Can only give rise to limited number of cell types (correct)
  • Is only present during early stages of development

    • Which one is NOT an example of cancer treatment by using stem cells?

  • Delivery of apoptosis inducing genes by human mesenchymal stem cells
  • Gene-directed enzyme prodrug therapy by Mesenchymal stem cells
  • Replacing cancerous hematopoietic cells with healthy bone marrow stem cells (correct)
  • Engineered Chimeric antigen receptor T cells (CART cells) therapy

    • Cells or tissue donated by a related or unrelated individual are called...

    <p>Allogenic</p> Signup and view all the answers

    Which of the following is NOT a way that genes can be introduced into the stem cells in gene therapy?

    <p>Bacteria</p> Signup and view all the answers

    In human clinical trials, which phase refers to the first testing of a new drug, treatment, or clinical device on a small group of people?

    <p>Phase 1</p> Signup and view all the answers

    Which of the following is NOT a criteria for pluripotency of embryonic stem cells?

    <p>Commitment for differentiation to several cell types</p> Signup and view all the answers

    What is a valid characteristic of a 'multipotent' stem cell?

    <p>Can be obtained at blastocyst stage of embryonic development</p> Signup and view all the answers

    A cancer stem cell can divide to give rise to...

    <p>Cancer stem cells, progenitor cells, improperly differentiated tumor cells</p> Signup and view all the answers

    What is a blastocyst?

    <p>A very early-stage embryo</p> Signup and view all the answers

    What is the primary criteria for pluripotency of embryonic stem cells?

    <p>Commitment for differentiation to several cell types</p> Signup and view all the answers

    Which phase of the human clinical trials involves the first testing of a new drug, treatment, or clinical device on a small group of people?

    <p>Phase 1</p> Signup and view all the answers

    What is a blastocyst?

    <p>A very early-stage embryo</p> Signup and view all the answers

    What distinguishes a tissue stem cell from an embryonic stem cell?

    <p>Can be obtained at blastocyst stage of embryonic development</p> Signup and view all the answers

    What can a cancer stem cell divide to give rise to?

    <p>Cancer stem cells, progenitor cells, improperly differentiated tumor cells</p> Signup and view all the answers

    What is the correct order in Gene-directed enzyme prodrug therapy by Mesenchymal Stem cells (MSCs) against cancer?

    <p>Pro-drug is catalyzed by the enzymatic cleavage to the activated form within the tumor environment</p> Signup and view all the answers

    Why human pluripotent stem cells (hPSCs) are preferred in drug screening due to their advantages?

    <p>Have the potential to differentiate into any cellular fate</p> Signup and view all the answers

    Which one is NOT a property of an ideal scaffold in tissue engineering?

    <p>Inaccessibility of cells into the scaffold</p> Signup and view all the answers

    Which stem cells have the most potency?

    <p>Totipotent</p> Signup and view all the answers

    Which of the following is NOT a way that genes can be introduced into the stem cells in gene therapy?

    <p>Bacteria</p> Signup and view all the answers

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