Podcast
Questions and Answers
What is the effect of treating 1000 patients with ramipril for 4 years?
What is the effect of treating 1000 patients with ramipril for 4 years?
- It prevents about 150 events in around 70 patients (correct)
- It prevents about 100 events in around 35 patients
- It prevents about 50 events in around 25 patients
- It prevents about 200 events in around 100 patients
What is a disadvantage of using composite end points?
What is a disadvantage of using composite end points?
- It leads to misattribution of statistically beneficial effects to each component end point (correct)
- It increases the sample size and cost
- It makes interpretation of results easier
- It is not useful in clinical trials
Why do investigators use composite end points in clinical trials?
Why do investigators use composite end points in clinical trials?
- To avoid reporting individual end points
- To decrease the sample size and cost (correct)
- To increase the sample size and cost
- To make interpretation of results more difficult
What is a potential problem when component end points move in opposite directions?
What is a potential problem when component end points move in opposite directions?
What is a surrogate end point?
What is a surrogate end point?
Why should results for each individual end point be reported?
Why should results for each individual end point be reported?
What is a limitation of composite end points?
What is a limitation of composite end points?
What is the advantage of using composite end points in terms of sample size?
What is the advantage of using composite end points in terms of sample size?
Why might investigators be interested in multiple outcomes?
Why might investigators be interested in multiple outcomes?
What is the problem with 'averaging' the overall effect of composite end points?
What is the problem with 'averaging' the overall effect of composite end points?