Podcast Beta
Questions and Answers
What is the purpose of antimicrobial optimization programmes like the US antimicrobial stewardship programmes (ASP)?
To improve clinical outcomes of patients with nosocomial infections and minimize adverse effects associated with antimicrobial use.
Why is analysis of antimicrobial use and results obtained in patients and microbiological resistance important?
It is crucial to ensure appropriate treatment, avoid unnecessary treatments, and reduce adverse effects and interactions.
What are the two key aspects highlighted in the text regarding antibiotic diversification strategies?
In vitro activity, lower resistance, and suitable efficacy in clinical trials, and the need for carbapenem-sparing strategies.
Which licence applies to the data made available in the article if not stated otherwise?
Signup and view all the answers
What should one do if their intended use of the material exceeds what is permitted by statutory regulation or the Creative Commons licence?
Signup and view all the answers
The absence of improved oxygenation, the need for mechanical ventilation in case of HAP, the persistence of fever or hypothermia together with purulent respiratory secretions, radiological worsening in more than 50% of the lung area or the development of septic shock or multi-organ failure after the onset of antibiotic treatment were more common in ______ with a worse clinical course. Amongst all of these aforementioned factors, the absence of improved oxygenation was significantly associated with greater mortality (OR 2.18 [1.24–3.84] p = 0.007).
Signup and view all the answers
In regard to both the original figure and course at 72–96 h of scales such as the CPIS or biomarkers such as C-reactive protein or procalcitonin, most studies agree over its ______ use and followup of infection. Page 6 of 13 MDROs: the link with colonization MDR Pseudomonas aeruginosa, extended spectrum beta-lactamase-producing enterobacteria (ESBL-E), meticillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii and carbapenemaseproducing Enterobacteriaceae (CPE) are the MDROs most commonly involved in HAP.
Signup and view all the answers
Knowledge of local ______ is essential because there are significant differences in the local prevalence of each MDRO.
Signup and view all the answers
MDR Pseudomonas aeruginosa, extended spectrum beta-lactamase-producing enterobacteria (ESBL-E), meticillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii and carbapenemaseproducing Enterobacteriaceae (CPE) are the MDROs most commonly involved in ________.
Signup and view all the answers
The absence of improved oxygenation was significantly associated with greater ________ (OR 2.18 [1.24–3.84] p = 0.007).
Signup and view all the answers
The persistence of fever or hypothermia together with purulent respiratory secretions was more common in patients with a worse clinical course in terms of ICU and hospital length of stay, duration of mechanical ventilation, and ________.
Signup and view all the answers
The development of septic shock or multi-organ failure after the onset of antibiotic treatment were more common in patients with a worse clinical course in terms of ICU and hospital length of stay, duration of mechanical ventilation, and ________.
Signup and view all the answers
In regard to both the original figure and course at 72–96 h of scales such as the CPIS or biomarkers such as C-reactive protein or procalcitonin, most studies agree over its ________ use and followup of infection.
Signup and view all the answers
Knowledge of local ________ is essential because there are significant differences in the local prevalence of each MDRO.
Signup and view all the answers
There are significant differences in the local prevalence of each ________.
Signup and view all the answers
