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Questions and Answers
What differentiates a poison from a remedy according to Paracelsus?
What differentiates a poison from a remedy according to Paracelsus?
- The right dose (correct)
- The method of administration
- The color of the substance
- The type of substance
Which of the following is considered dose dependent drug toxicity?
Which of the following is considered dose dependent drug toxicity?
- Side effects (correct)
- Overdose
- Idiosyncratic hypersensitivity
- Allergic reactions
What can happen if β blockers affect the β receptors in the bronchi?
What can happen if β blockers affect the β receptors in the bronchi?
- Bronchoconstriction (correct)
- Vasodilation
- Increased heart rate
- Reduced blood pressure
Which adverse effects of a drug are considered when taken in excess of the therapeutic range?
Which adverse effects of a drug are considered when taken in excess of the therapeutic range?
Which type of drug toxicity can manifest as idiosyncratic hypersensitivity?
Which type of drug toxicity can manifest as idiosyncratic hypersensitivity?
Why is it important to know the side effect profile of a drug?
Why is it important to know the side effect profile of a drug?
What is the primary objective of biotransformation?
What is the primary objective of biotransformation?
How does the body defend against foreign substances?
How does the body defend against foreign substances?
Which route of excretion involves volatile compounds being exhaled?
Which route of excretion involves volatile compounds being exhaled?
Which route of absorption allows chemicals to enter the blood via the alveoli?
Which route of absorption allows chemicals to enter the blood via the alveoli?
Where do lipophilic compounds like DDT tend to store in the body?
Where do lipophilic compounds like DDT tend to store in the body?
How does bioactivation impact the clearance rate of compounds?
How does bioactivation impact the clearance rate of compounds?
What effect can biotransformation have on the concentration of active compounds at the target site?
What effect can biotransformation have on the concentration of active compounds at the target site?
What is the process by which a chemical agent translocates throughout the body called?
What is the process by which a chemical agent translocates throughout the body called?
Which factor does NOT influence the rate of distribution of a toxicant in the body?
Which factor does NOT influence the rate of distribution of a toxicant in the body?
Which organ plays a role in biliary excretion of toxicants?
Which organ plays a role in biliary excretion of toxicants?
How can urinary excretion aid in eliminating toxicants?
How can urinary excretion aid in eliminating toxicants?
How can rapid mobilization of fat affect blood concentration of lipophilic compounds?
How can rapid mobilization of fat affect blood concentration of lipophilic compounds?
What is the potential consequence of an overdose of barbiturates?
What is the potential consequence of an overdose of barbiturates?
Which drug overdose leads to liver damage by saturating the normal conjugation reaction?
Which drug overdose leads to liver damage by saturating the normal conjugation reaction?
What does N acetylcysteine act as when given to treat a paracetamol overdose?
What does N acetylcysteine act as when given to treat a paracetamol overdose?
What is an idiosyncratic reaction to a drug dose characterized by?
What is an idiosyncratic reaction to a drug dose characterized by?
What is the main function of glutathione in the body's response to paracetamol overdose?
What is the main function of glutathione in the body's response to paracetamol overdose?
Which drug causes muscle paralysis and respiratory depression at high concentrations?
Which drug causes muscle paralysis and respiratory depression at high concentrations?
What is a common cause of death in an acutely poisoned patient?
What is a common cause of death in an acutely poisoned patient?
How does activated charcoal aid in preventing the absorption of poisons?
How does activated charcoal aid in preventing the absorption of poisons?
What is one method mentioned to alter biotransformation as a way to prevent the toxicity of compounds?
What is one method mentioned to alter biotransformation as a way to prevent the toxicity of compounds?
In treating acute poisoning, what is the first goal mentioned in the strategies outlined?
In treating acute poisoning, what is the first goal mentioned in the strategies outlined?
What is one way to determine the location and ratio of ionized to un-ionized poison in the body?
What is one way to determine the location and ratio of ionized to un-ionized poison in the body?
