Snell’s Clinical Neuroanatomy Chapter 9 - Reticular Formation and Limbic System

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Questions and Answers

Which of the following accurately describes the effect of damage to the cerebral cortex on a patient who is in a deep coma and has damage to the right side of their head?

  • The patient will recover fully, as the brain's plasticity will enable other regions to take over the functions of the damaged cortex.
  • The patient will exhibit increased motor function due to the reticular formation compensating for cortical damage.
  • The patient will regain consciousness as long as the reticular formation is intact, allowing for the resumption of cognitive functions.
  • The patient will remain in a vegetative state due to the irreversible loss of cerebral cortex function, despite possible wake-sleep cycles driven by the reticular formation. (correct)

Which statement correctly describes the role of the reticular formation in the central nervous system?

  • It is a diffuse network that modulates various functions including skeletal muscle activity, somatic and visceral sensations, and consciousness. (correct)
  • It primarily functions as a relay station for sensory information heading to the cerebral cortex, without influencing motor functions.
  • It strictly controls autonomic functions such as heart rate and digestion, independent of any influence from the cerebral cortex.
  • It serves solely as a protective barrier for the brainstem, preventing damage from toxins and pathogens circulating in the bloodstream.

What is the functional consequence of the reticular formation's extensive connections within the central nervous system?

  • Exclusive control over higher-order cognitive functions, independent of basic sensory and motor processes.
  • Integrated modulation of multiple systems, influencing muscle activity, autonomic responses, and consciousness. (correct)
  • Highly specific responses to sensory stimuli due to segregated direct pathways.
  • Independent control over individual organs and muscles without any central coordination.

How does the reticular formation influence skeletal muscle activity?

<p>Through the reticulospinal and reticulobulbar tracts modulating alpha and gamma motor neurons. (B)</p> Signup and view all the answers

In what way does the reticular formation contribute to the so-called “gating mechanism” of pain perception?

<p>By selectively enhancing or inhibiting ascending pathways, thereby modulating the perception of pain. (A)</p> Signup and view all the answers

How do polysynaptic pathways within the reticular formation contribute to the integration of somatic and visceral functions?

<p>They allow for the convergence and integration of both somatic and visceral sensory inputs, enabling coordinated responses. (B)</p> Signup and view all the answers

What cytoarchitectural characteristic makes it difficult to trace specific anatomical pathways within the reticular formation using traditional staining techniques?

<p>The neuronal groups are poorly defined and lack clear boundaries. (D)</p> Signup and view all the answers

How does the reticular formation influence the activity of the autonomic nervous system (ANS)?

<p>By coordinating higher-level inputs from the cerebral cortex and hypothalamus with the sympathetic and parasympathetic outflow. (B)</p> Signup and view all the answers

Which neurotransmitter plays a key role in the excitatory processes of the reticular activating system (RAS)?

<p>Acetylcholine (C)</p> Signup and view all the answers

How does the reticular formation maintain wakefulness, according to current understanding?

<p>Through continuous projection of sensory information to the cerebral cortex, causing an 'awakening' effect. (A)</p> Signup and view all the answers

What is the primary outcome of damage limited to the reticular formation?

<p>Significant changes in the level of consciousness. (A)</p> Signup and view all the answers

What distinguishes the function of the reticular formation from that of specific sensory pathways?

<p>The reticular formation provides a general level of arousal and alertness, while sensory pathways transmit specific sensory information. (C)</p> Signup and view all the answers

Which of the following is NOT a primary anatomical component of the limbic system?

<p>Cerebellum (C)</p> Signup and view all the answers

Which structure connects the hippocampus to the mammillary bodies which are part of the hypothalamus?

<p>Fornix (B)</p> Signup and view all the answers

What is the functional significance of the six-layered cortex within the parahippocampal gyrus, as it transitions into the hippocampal formation?

<p>It provides a site for initial encoding for new memories. (B)</p> Signup and view all the answers

Following bilateral removal of the temporal lobes, monkeys demonstrated docility, changes in appetite, unusual sexual behavior, and the inability to visually recognize objects. What is the name of this syndrome?

<p>Klüver-Bucy Syndrome (A)</p> Signup and view all the answers

After suffering damage to the hippocampi, an individual is unable to form new long-term memories. What condition would one use to describe them?

<p>Anterograde amnesia (C)</p> Signup and view all the answers

Why does stimulating the limbic system in patients experiencing a temporal lobe seizure trigger bizarre sensations and behaviors?

<p>Because the limbic system is involved in emotions, memory, and basic drives. (B)</p> Signup and view all the answers

What role does the hypothalamus play within the limbic system?

<p>It has a major output pathway. (D)</p> Signup and view all the answers

What is the primary function of the alveus, fimbria, and fornix within the limbic system?

<p>Connecting different structures. (D)</p> Signup and view all the answers

The cortex has a few distinct layers. What are the main layers within the hippocampus?

<p>Molecular, pyramidal, and polymorphic layers (D)</p> Signup and view all the answers

What connections do fibers originating from the cingulate gyrus form?

<p>hippocampus (B)</p> Signup and view all the answers

How do the medial and lateral longitudinal striae contribute to the function of the limbic system?

<p>By facilitating communication between the hippocampus and the cerebral cortex. (C)</p> Signup and view all the answers

In the context of limbic system function, how does memory of remote events remain accessible despite hippocampal damage?

<p>Remote memories are already consolidated in other cortical areas. (B)</p> Signup and view all the answers

How does the limbic system contribute to the integration of environmental stimuli with emotional and behavioral responses?

<p>By processing sensory information through the hypothalamus and its connections. (A)</p> Signup and view all the answers

Stimuli within the environment results in the alteration of the amygdala. What results occur to any reactions and behaviors that occur?

<p>Calm reactions and stable mood are replaced by a highly volatile or aggressive state (B)</p> Signup and view all the answers

If the neurotransmitter responsible for limiting the worst symptoms of schizophrenia is blocked, which receptors are associated?

<p>Limbic Dopamine (C)</p> Signup and view all the answers

When the effects of long-term memory is taken for granted, this region of the brain is actually still necessary. What is the name of the complex structure that helps for the basis of new and recent memories?

<p>Hippocampus (D)</p> Signup and view all the answers

When discussing sleep and wakefullness, which system is critical in both the maintenance of this area?

<p>Reticular Formation (B)</p> Signup and view all the answers

After having damage to many parts of the brain, there is often a time for healing and recovery. Where does plactiscity often occur within the structure in the hippocampus?

<p>Molecular Layer (B)</p> Signup and view all the answers

A patient is struggling to move their muscles correctly. What area of the brain could a neurologist study in order to see the muscle reflex, at a closer proximity level?

<p>Anterior horn cells of the spinal cord (A)</p> Signup and view all the answers

Due to its many connections to the various brain parts, what can the reticular formation easily support?

<p>Unanticipated Function (C)</p> Signup and view all the answers

The limbic system has some impacts and control over the system. What does it have the most control and aspects over?

<p>Control Over emotions (C)</p> Signup and view all the answers

Due to the body structure and many aspects of brain signals, what happens to patients post-operation while addressing aggressive behavior?

<p>Decreased aggression (A)</p> Signup and view all the answers

The neurons in the system are not the traditional function of standard neurons. How are these structured for memory and process?

<p>Big areas that are dense with smaller groups (A)</p> Signup and view all the answers

How does the anatomical arrangement of the reticular formation contribute to its functional versatility?

<p>Nerve cells and fibers are arranged in a net-like structure, extending throughout the central nervous system. (B)</p> Signup and view all the answers

What is the functional significance of the reticular formation's influence on both alpha and gamma motor neurons?

<p>It enables the modulation of muscle tone and reflex activity, facilitating both voluntary movement and posture maintenance. (C)</p> Signup and view all the answers

In the context of pain modulation, what is the role of the reticular formation's 'gating mechanism'?

<p>It acts as a filter, influencing the transmission of ascending pain pathways and modulating the perception of pain. (B)</p> Signup and view all the answers

How do the polysynaptic pathways within the reticular formation facilitate the integration of somatic and visceral functions?

<p>By creating a complex network of connections that allows for the coordination of autonomic, endocrine, and behavioral responses to internal and external stimuli. (A)</p> Signup and view all the answers

How does damage to the cerebral cortex spare the reticular formation, and what is the functional consequence of this selective sparing?

<p>The patient may exhibit sleep-wake cycles and spontaneous respiration, but remains unaware of their environment due to the loss of cortical function. (B)</p> Signup and view all the answers

Considering its widespread connections, how does the reticular formation contribute to the maintenance of consciousness?

<p>It receives sensory input and projects this information to various parts of the cerebral cortex, which maintains a state of wakefulness. (B)</p> Signup and view all the answers

What is the most likely explanation for the bizarre sensations and behaviors observed during temporal lobe seizures involving the limbic system?

<p>The seizure disrupts the normal function of the limbic system, leading to the inappropriate triggering of stored memories, emotions, and behaviors. (B)</p> Signup and view all the answers

In what way does the extensive interconnectivity within the limbic system contribute to its role in emotional regulation?

<p>It enables the integration of sensory information, past experiences, and internal states to generate a nuanced and context-dependent emotional response. (B)</p> Signup and view all the answers

If a patient exhibits anterograde amnesia following damage to the hippocampi, yet retains memory of remote past events, how can this phenomenon be explained?

<p>Remote memories are consolidated and stored in other cortical regions, independent of the hippocampus. (A)</p> Signup and view all the answers

How does the anatomical location of the limbic system, bordering the cerebral cortex and hypothalamus, inform its function?

<p>It enables it to integrate higher-level cognitive processes with basic drives and physiological functions, influencing a wide range of behaviors. (B)</p> Signup and view all the answers

How can lesions of the amygdala produce a calming effect?

<p>The lesions may remove a source of excitation and increase the activity of inhibitory neurons. (A)</p> Signup and view all the answers

Why temporal lobe epilepsy may present an aura?

<p>The olfactory or acoustic experiences from epilepsy precedes seizures. (D)</p> Signup and view all the answers

Following bilateral removal of the temporal lobes, monkeys demonstrated docility, changes in appetite, unusual sexual behavior, and the inability to visually recognize objects. What structure is involved?

<p>Amygdala (B)</p> Signup and view all the answers

What role does the limbic system play in learning and memory?

<p>It enables the formation of new declarative memories and emotional associations. (C)</p> Signup and view all the answers

The Papez circuit is heavily involved within which brain region?

<p>Limbic System (A)</p> Signup and view all the answers

What might be the neurological cause of someone smelling an unpleasant odor before a seizure?

<p>This might be because they are experiencing temporal lobe epilepsy. (C)</p> Signup and view all the answers

How can the limbic system respond to fearful stimuli?

<p>By causing emotional behaviors to specific environmental changes. (D)</p> Signup and view all the answers

How can the cortex influence sensation and consciousness?

<p>Though the reticular formation (D)</p> Signup and view all the answers

How does damage within the limbic system cause emotional instability?

<p>Damage to certain part of the brain causes changes in sensations. (C)</p> Signup and view all the answers

What is the contribution of the Fimbria, within the limbic system structure?

<p>Bundle of fibers to lead to the Fornix. (A)</p> Signup and view all the answers

What is the effect of blocking dopamine receptors in the limbic system for schizophrenic patients?

<p>Lessen the worst effects. (D)</p> Signup and view all the answers

In which area of the brain would a researcher look for dysfunction related to a loss of the ability to recall recent events?

<p>Hippocampus (A)</p> Signup and view all the answers

Which neurotransmitter is critical to triggering the excitation of the reticular activating system?

<p>Acetylcholine (A)</p> Signup and view all the answers

Why are those with combined amygdaloid and hippocampal injuries face a high risk of memory loss?

<p>The combination of systems causes a greater deal of memory loss. (D)</p> Signup and view all the answers

What would happen if an animal was subjected to bilatteral removal of parts of the brain?

<p>Change in behavior or docile. (C)</p> Signup and view all the answers

Because the limbic circuitry is highly complex, especially in memorization, where should one begin to study?

<p>Memorization systems are complex in circuits. (B)</p> Signup and view all the answers

What occurs when there is damage to the septal nuclei?

<p>Memory loss. (A)</p> Signup and view all the answers

What is the role of the cingulate gyrus, as a component of the limbic system?

<p>Response. (D)</p> Signup and view all the answers

What are the key symptoms of the Klüver-Bucy syndrome?

<p>Visual agnosia, hyperorality, and hypersexuality. (B)</p> Signup and view all the answers

A patient is unable to recall memories before a specific date, but can form new memories from that date forward. What is this disorder?

<p>Retrograde amnesia (A)</p> Signup and view all the answers

Where is the hippocampus located?

<p>Temporal (D)</p> Signup and view all the answers

Of the following, what is the main output of the limbic system?

<p>Hypothalamus (D)</p> Signup and view all the answers

Damage to the hippocampus results in ___________.

<p>Inability to produce new memories. (B)</p> Signup and view all the answers

Which aspect of motor control is most directly influenced by the reticular formation through its connections to alpha and gamma motor neurons?

<p>Maintaining muscle tone and modulating reflex activity (B)</p> Signup and view all the answers

In the nervous system, what functional role is served by the reticular formation's modulatory influence on ascending sensory pathways?

<p>To selectively filter and prioritize sensory information, influencing attention and arousal. (B)</p> Signup and view all the answers

How does the reticular formation's influence on the autonomic nervous system (ANS) contribute to homeostasis?

<p>By coordinating sympathetic and parasympathetic responses to maintain visceral functions. (B)</p> Signup and view all the answers

When considering the impact of the reticular formation on an individual's sleep-wake cycle, what is the functional significance of its widespread connections to the cerebral cortex?

<p>To provide the cortex with the sensory input necessary for maintaining wakefulness and alertness. (A)</p> Signup and view all the answers

Predict the most likely outcome if a person experiences selective damage to interneurons within the spinal cord, directly affecting the reticulospinal tract.

<p>Impaired modulation of muscle tone and reflexes, leading to spasticity or flaccidity. (D)</p> Signup and view all the answers

How do pharmaceutical interventions targeting specific neurotransmitter systems of the reticular formation affect overall brain function?

<p>They can modulate arousal, attention, and sleep-wake cycles while influencing motor and sensory processing. (B)</p> Signup and view all the answers

Damage to the cingulate gyrus would most likely result in:

<p>Deficits in processing emotions and linking them to memories. (B)</p> Signup and view all the answers

What would be the most significant consequence of damage to the mammillothalamic tract?

<p>Memory deficits and impaired spatial orientation. (B)</p> Signup and view all the answers

If a patient presents with deficits in both memory and olfaction, which limbic structure is most likely affected?

<p>Uncus (B)</p> Signup and view all the answers

What is the functional significance of the alveus in the context of hippocampal function?

<p>It facilitates the flow of information from the hippocampus to other brain regions. (A)</p> Signup and view all the answers

How does neuronal organization in the hippocampal formation differ from the six-layered structure of the cerebral cortex, and what implications does this have for information processing?

<p>The hippocampus has a distinct three-layered structure, optimizing it for pattern separation and rapid encoding. (A)</p> Signup and view all the answers

How would simultaneous activation of the amygdala and hippocampus impact an individual's behavior?

<p>It could lead to enhanced memory formation of emotionally charged events. (D)</p> Signup and view all the answers

Considering the complex interplay of structures within the limbic system, what best describes how the amygdala and hippocampus interact?

<p>The amygdala modulates the emotional content of memories encoded by the hippocampus. (D)</p> Signup and view all the answers

What role does the anterior nucleus of the thalamus play within the Papez circuit?

<p>Relaying information from the mammillary bodies to the cingulate gyrus. (D)</p> Signup and view all the answers

Following damage to the fornix, which of the following cognitive deficits would be most likely to arise?

<p>Difficulties in forming and retrieving certain types of memories. (C)</p> Signup and view all the answers

Predict the most likely outcome for an individual with bilateral lesions of the amygdala who is exposed to a previously fear-inducing stimulus.

<p>A reduced or absent conditioned fear response. (B)</p> Signup and view all the answers

Given its various aspects of influencing environmental and emotional states, the limbic system has control primarily what function overall?

<p>Visceral responses and emotional drive (C)</p> Signup and view all the answers

If the hippocampus stops processing recent memory after damage, what still results in the ability to remember remote events?

<p>Association pathways (A)</p> Signup and view all the answers

Following the removal of the amygdaloid structures, what happens to the behaviors or reactions?

<p>Decreased aggressiveness and emotional instability with increases intrest in food and sexual activity (A)</p> Signup and view all the answers

What is considered the primary role for how one can consider the hypothalamus to function?

<p>Acts as a major output pathway for the limbic system (C)</p> Signup and view all the answers

Why is a complete understaning of the reticuar formation seemingly unneccesary to fully understood or remembered?

<p>It's complexcity (D)</p> Signup and view all the answers

If a patient is experiencing a decrease in aggressiveness, coupled with an increase in interest in food and hyper sexuality, what structure is that damage is likely to occur?

<p>Amygdaloid (C)</p> Signup and view all the answers

When the effects are not enduing and not processing into the limbic system for memory, what can the individual not do?

<p>The ability to store long-term memory (C)</p> Signup and view all the answers

Clinical research often times, finds one thing to look for when discussing that the drugs will be lessened in side effects/symptoms? What is the agent you should aim for?

<p>Willl block just the limbic dopamine receptors without directly effecting the motor (D)</p> Signup and view all the answers

During the testing, an aura of olfactory experience is known within the anatomy of the brain to be associated in what area?

<p>Temporal lobe (B)</p> Signup and view all the answers

Following direct damage the structures of hippocampus itself, it often changes to what? (Hint: three is the common trend)

<p>A three-layered arrangement optimizing it fo the pattern separation and rapid encoding (D)</p> Signup and view all the answers

When referencing a brain section specifically and there is no visual identification, what helps the corononal section?

<p>Alveus (B)</p> Signup and view all the answers

Within many regions of the brain, there are major functions that do not line up with how they appear, which is related to its function?

<p>Sensory and scattered small neurons (C)</p> Signup and view all the answers

The reticular formation has only ascending pathways that influence the cerebral cortex.

<p>False (B)</p> Signup and view all the answers

Damage to the reticular formation always results in permanent wakefulness.

<p>False (B)</p> Signup and view all the answers

Schizophrenia symptoms can be lessened by blocking dopamine receptors in the limbic system.

<p>True (A)</p> Signup and view all the answers

The reticular formation primarily influences the somatic nervous system, with minimal impact on the autonomic and endocrine systems.

<p>False (B)</p> Signup and view all the answers

In an individual with Klüver-Bucy syndrome, removal of temporal lobes leads to increased aggression and fear responses.

<p>False (B)</p> Signup and view all the answers

Temporal lobe epilepsy is often characterized by visual auras.

<p>False (B)</p> Signup and view all the answers

The alveus, fimbria, fornix, and stria terminalis are the connecting pathways of the limbic system.

<p>True (A)</p> Signup and view all the answers

The hippocampus is located within the frontal lobe.

<p>False (B)</p> Signup and view all the answers

The limbic system is primarily involved in motor control.

<p>False (B)</p> Signup and view all the answers

The mammillothalamic tract connects the mammillary body to the cerebellum.

<p>False (B)</p> Signup and view all the answers

The degree of wakefulness is dependent on the activitiy of the reticular formation.

<p>True (A)</p> Signup and view all the answers

Damage to the hippocampus primarily affects long-term memory formation.

<p>True (A)</p> Signup and view all the answers

The reticular formation plays an unimportant role in controlling the muscles of facial expression.

<p>False (B)</p> Signup and view all the answers

The hippocampus has direct connections to the cerebral cortex, allowing it to influence a wide range of cognitive functions.

<p>False (B)</p> Signup and view all the answers

The fimbria is the efferent fiber bundle that originates from the amygdala.

<p>False (B)</p> Signup and view all the answers

The reticular formation can influence skeletal muscle activity through the reticulospinal ad reticulobulbar tracts.

<p>True (A)</p> Signup and view all the answers

The amygdala, despite its role in emotion, has no direct connections to the olfactory system.

<p>False (B)</p> Signup and view all the answers

The limbic system is essential for all forms of memory, including both short-term and long-term storage.

<p>False (B)</p> Signup and view all the answers

The cerebellum is considered a part of the limbic system due to its close involvement in emotional regulation and memory processing.

<p>False (B)</p> Signup and view all the answers

The hippocampus primarily communicates with the rest of the brain via direct projections to the spinal cord and peripheral nerves.

<p>False (B)</p> Signup and view all the answers

Match the components of the limbic system with their descriptions:

<p>Amygdala = Processes emotions, especially fear and aggression Hippocampus = Involved in the formation of new memories Hypothalamus = Controls the autonomic nervous system and hormone release Thalamus = Relays sensory and motor signals to the cerebral cortex</p> Signup and view all the answers

Match the reticular formation functions with the corresponding physiological processes:

<p>Muscle tone control = Regulation of alpha and gamma motor neurons Sensory modulation = Influence on ascending sensory pathways Autonomic control = Regulation of sympathetic and parasympathetic outflow Sleep-wake cycle = Modulation of cortical activity and arousal</p> Signup and view all the answers

Match each structure with its location:

<p>Reticular formation = Extends through the central axis of the central nervous system Limbic system = Border zone between the cerebral cortex and the hypothalamus Hippocampus = Floor of the inferior horn of the lateral ventricle Amygdala = Anterior and partly superior to the tip of the inferior horn of the lateral ventricle</p> Signup and view all the answers

Match the neurotransmitter systems with their roles in the reticular formation:

<p>Monoamine groups = Influence functions in specific CNS areas Acetylcholine = Role as excitatory neurotransmitter Motor neurons = Modulate muscle tone reflex activity Sensory systems = Influence all ascending pathways that pass to supraspinal levels</p> Signup and view all the answers

Associate the limbic system structures with the behavioral or cognitive outcomes they are associated with:

<p>Damage to corticol connections = Conversion of short-term memory to long-term memory Stimulation of parts of Limbic system = Influences sense of emotions Limbic system = Integration and connections that influence aspects of emotional behavior ANS autonomic nervous system and endocrine system = Controls many aspects of emotional behavior</p> Signup and view all the answers

Match the clinical conditions with the changes in the amygdaloid complex:

<p>Amygdaloid destruction = Many cases decrease in aggressiveness and increased desire for food Unilateral amygdalar or bilateral destruction = Aggressive behavior in many cases Amydaloid resections = Reestablish social excitability and bring about normalization of behavior Amygdala = Responsible for processing emotions, especially fear and aggression.</p> Signup and view all the answers

Relate the following components with their functions in the reticular formation:

<p>Reticular bulbospinal tracts = Pathway through which the reticular formation can influence the activity of motor neurons. Reticular formation role of sensation = Can influence ascending pathways and pain reception Higher control of the ANS = can come from areas in the brain and influence blood pressure Reticular Formation multiple ascending pathways = carries sensory information related to levels of consciousness</p> Signup and view all the answers

Match the following structures with what they affect:

<p>Spinoreticular = Tracts project from the spinal cord. Vestibular = Tracts project from the cranial nerve nuclei Internal capsule = Allows projections to the cerebral cortex Cerebellum = Projects from the cerebellum to the cerebelloreticular pathway</p> Signup and view all the answers

Match the structure with the role they provide:

<p>Hippocampus role = Helps short-term memory migrate to long-term memory Damage to Hippocampus = A person can not convert short-term memory in to long-term memory. Memory = Will not allow you to recall the remote parts of the past if that information was not stored before lesion. amnesia = when conditions is anterograde</p> Signup and view all the answers

Associate the symptoms and related systems:

<p>Reticular Formation in Epilepsy = It is possible that Epilepsy can be lead to loss of conciousness Schizophrenia = Can be tied to too much dopamine expression Pharmacologic agent = If not careful, can have major motor side-effects on dopaminergic within the extrapyramidal system Drugs to limit Dopamine with careful extrapyramidal control = Can bring about reduction in negative affect such as hallucinations</p> Signup and view all the answers

Flashcards

Reticular Formation

Net of nerve cells and fibers in the central nervous system extending from the spinal cord to the cerebrum.

Reticular Formation Functions

Influences skeletal muscle, sensations, autonomic and endocrine systems, and consciousness.

Limbic System Structures

Includes the subcallosal, cingulate, and parahippocampal gyri, the hippocampal formation, the amygdaloid nucleus, the mammillary bodies, and the anterior thalamic nuclei

Hippocampal Formation

Region made of the hippocampus, dentate gyrus, and parahippocampal gyrus.

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Limbic System Roles

Limbic structures are involved in the development of emotion, visceral responses, and the hippocampus impacts recent memory.

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Schizophrenia Treatment

Dopamine receptors blocked, lessens disordered thinking, blunted affect, and withdrawal.

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Amygdaloid Nucleus Destruction

Cause decreased aggressiveness, emotional instability, restlessness; increased interest in food.

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Temporal Lobe Seizure

Experiencing acoustic/olfactory aura indicates initial start of seizure in temporal lobe.

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Reticular Formation

Reticular formation modulates motor systems and influences the state of consciousness

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Ascending Sensory Pathways

The ascending sensory pathways are responsible for consciousness.

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Functions of the Limbic System

Sensations of emotion and the visceral responses, plus the hippocampus is linked to recent memory

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Vegetative State

Awake but unaware due to reticular formation's role in wakefulness and cerebral cortex damage.

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Reticular Formation Extent

Extends from spinal cord through brain, influencing various CNS levels.

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Reticular Formation Columns

Intermediate, magnocellular, and parvocellular areas.

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Reticular Formation Connections

Connects to most CNS parts; afferent pathways to the reticular formation from spinal cord and cranial nerves.

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Skeletal Muscle Control

Reticulospinal and reticulobulbar tracts influence alpha and gamma motor neurons to modulates muscle tone and reflexes.

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Reticular Activating System

Arousal and consciousness controlled by multiple ascending pathways through the reticular formation to the cerebral cortex.

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Limbic System Anatomy

Includes regions such as subcallosal, cingulate, and parahippocampal gyri, amygdaloid nucleus, and hippocampus

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Hippocampus Location

Located in the floor of the inferior horn of the lateral ventricle.

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Hippocampus Damage

Damage prevents the storage of long-term memories.

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Limbic System Pathways

Alveus, fimbria, fornix, and stria terminalis.

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Limbic Output

Hypothalamus is the main output pathway.

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The Limbic system

Synthesizes, integrates responses with the environment

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Reticular Formation Placement

Located in the center of the nervous system and receives input from sensory systems and influences CNS levels.

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Reticular Fiber Pathways

Polysynaptic pathways exist, with crossed and uncrossed ascending and descending pathways, crucial for somatic and visceral functions.

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Reticular Formation Damage

Can cause persistent unconsciousness, possibly from inhibiting reticular formation activity.

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Hippocampus Definition

A curved elevation of gray matter along the floor of the inferior horn of the lateral ventricle.

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Amygdaloid Deconstruction Effect

Amygdaloid complex destruction that results in a decreeased aggressiveness, emotional instability, restlessness; increased interest in food.

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Limbic System Components

Includes the anterior thalamic nuclei, amygdala, hippocampal formation, mammillary bodies, and various cortical areas.

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What is the Reticular Formation?

A network of brainstem nuclei influencing mood, arousal, and pain perception.

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What is the Parahippocampal Gyrus?

Located on the medial edge of the temporal lobe, between the hippocampal fissure and collateral sulcus.

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What area is responsible for wakefullness?

The area involved in wakefulness is located in the brainstem.

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Reticular Formation Sensation Control

By the virtue of its location in the cerebospinal axis, it influences all ascending pathways to supraspinal levels.

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Reticular Formation Transmitter-Specific Cells

These groups influence functions in specific CNS areas. Example, monoamine cell groups in well defined areas.

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Amygdaloid Nucleus

Located anterior and superior to the inferior horn of the lateral ventricle, resembling an almond in shape.

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Alveus

A thin layer of white matter on the superior surface of the hippocamus.

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Stria Terminalis

Originates from the posterior amygdaloid nucleus.

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Anterograde Amnesia

Loss of the ability to create and retain new memories after an event.

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Study Notes

Retitcular Formation and Limbic System

  • A 24 year old medical student is rushed to the ER after a motorcycle accident, he is found to be unconscious and unresponsive, with a skull fracture
  • He fails to respond to verbal stimuli or deep painful pressure
  • Plantar reflex is extension, and other reflexes like corneal, tendon, and pupillary are absent
  • A CT scan shows skull fracture on the parietal bone
  • After a week, he becomes conscious, but shows no awareness of his surroundings
  • He expresses limited primitive reflexes, and doesn't speak or respond to commands
  • Though he has sleep/wake cycles, he doesn't respond to pain appropriately
  • The neurologists determines the reticular formation survived the accident
  • The reticular formation allows the patient to breath unassisted, but the cortex is dead
  • The patient will remain in a vegetative state and his neurologic condition is unchanged 6 months later
  • The reticular formation was believed to be a vague part of the brain, but it is now know to play an important role
  • The limbic system was used to describe the part of the brain between the cerebral cortex and the hypothalamus, but it is now known to play a vital role in emotion, behavior, drive, and memory

Reticular Formation

  • Resembles a net(reticular)
  • Consists of nervous tissues
  • extends through the CNS from the spinal cord to cerebrum
  • Strategically placed among nerve tracts and nuclei
  • Receives inputs from most of the sensory systems
  • Has efferent fibers
    • Descend to influence nerve cells at all CNS levels
  • Exceptionally long dendrites permit input from ascending and descending pathways
  • A large number of connections allows it to influence skeletal muscles
  • Can influence somatic and visceral sensations
  • Can influence autonomic and endocrine systems, and consciousness

Arrangement

  • Consists of a deeply placed continuous network of nerve cells that extend from the spinal cord, medulla oblongata, pons, midbrain, subthalamus, and to the thalamus
  • Network divided into three longitudinal columns
    • The median column - Occupies the median plane, consists of intermediate-size neurons
    • The medial column - Large neurons
    • The lateral column - Small neurons
  • Neurons are poorly defined, therefore tracing anatomical pathways are elusive
  • Modern neurochemistry techniques identify highly organized groups of transmitter specific cells
  • Transmitter-specific cells can influence functions in specific CNS area
  • Monoaminergic groups of cells are located in well-defined areas
  • Polysynaptic pathways exist
  • Both crossed and uncrossed ascending and descending pathways are present, involving somatic and visceral functions
  • The reticular formation is continuous with the gray matter inter neurons in the spinal cord
  • Impulses are relayed to the cortex
  • A substantial projection of fibers also leaves the reticular formation to enter the cerebellum

Projections

  • Afferent pathways project from parts of the CNS
    • Spinoreticular and spinothalamic tracts, and the medial lemniscus project from the spinal cord
    • Vestibular, acoustic, and visual pathways ascend from cranial nerve nuclei
    • The cerebelloreticular pathway projects from the cerebellum
  • Afferent tracts project from the subthalamic, hypothalamic and thalamic nuclei and from the corpus striatum and limbic system
  • Fibers arise in the primary motor strip of the frontal lobe as well as the somesthetic cortex of the parietal lobe

Efferent Projections

  • Many efferent pathways extend down to the brainstem and the spinal cord through reticulobulbar and reticulospinal tracts
  • Other pathways extend to the sympathetic outflow and craniosacral parasympathetic outflow
  • Pathways extend to the corpus striatum, cerebellum, red nucleus, substantia nigra, tectum, as well as the nuclei of thalamus, subthalamus, and hypothalamus
  • Most regions of the cerebral cortex receive efferent fibers

Functions

  • Connections to all parts of the nervous system allow it to serve many functions
  • Can influence alpha and gamma motor neurons
  • Assist with reciprocal inhibition
  • Can modulate muscle tone and reflex activity
  • Also assists when standing, by helping to maintain the tone of antigravity muscles
  • Aids in control of facial expression muscle
  • Can modulate somatic and visceral sensations via ascending pathways
  • Important in "gating mechanism" for controlling pain perception
  • Can function as higher control for ANS from cerebral cortex, hypothalamus, and other subcortical nuclei
  • influences synthesis/release of releasing or release-inhibiting factors for activity of hypophysis cerebri
  • can strongly influence biological clock rhythms because of multiple afferent/efferent pathways to the hypothalamus
  • crucial for arousal and consciousness via multiple ascending pathways project sensory information to higher centers

Limbic System

  • It is involved with emotion, behavior, drive, and memory
  • Anatomically, it contains subcallosal, cingulate, and parahippocampal gyri
  • it contains hippocampal formation, amygdaloid nucleus, and mammillary bodies
  • the anterior thalamic nucleus is also included
  • The alveus, fimbria, fornix, mammillothalamic tract, and stria terminalis are also included
  • The hippocampal formation consists of the hippocampus, the dentate gyrus, and the parahippocampal gyrus.
    • The hippocampus is a curved elevation of gray matter in the inferior horn of the lateral ventricle

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