32 Questions
What is the main cause of gout disease?
High levels of uric acid in the blood
Where is most uric acid reabsorbed in the body?
Proximal tubules
What is the primary source of uric acid in the body?
Breakdown of ingested nucleic acids
What percentage of uric acid elimination is accounted for by renal excretion?
70%
Where does uric acid get transported from the liver to?
Kidney
What happens to uric acid at high concentrations in the body?
It gets deposited in joints and tissues, causing painful inflammation
What is the predominant form of uric acid in acidic urine?
Uric acid crystals
What is the main reason for measuring uric acid?
To confirm diagnosis and monitor treatment of gout
What genetic disorder is caused by the complete deficiency of HGPRT?
Lesch - Nyhan syndrome
Which disease is found primarily in men and usually diagnosed between 30 and 50 years of age?
Gout
What is the usual plasma uric acid concentration in patients with gout?
Greater than 6mg/dL
Which condition may lead to the development of renal calculi in patients with gout?
Hyperuricemia due to overproduction of uric acid
Which type of patients are very susceptible to the development of renal calculi and should have their uric acid concentration monitored?
Patients on chemotherapy for leukemia and lymphoma
What is the main focus of the Musculoskeletal Block related to purine degradation and gout?
Uric acid formation and its association with gout
What is another common cause of elevated plasma uric acid concentration, besides overproduction of uric acid?
Increased metabolism of cell nuclei
What is the reason for monitoring uric acid concentration in patients on chemotherapy?
To prevent uric acid nephropathy
What is the primary source of uric acid in the body?
Breakdown of ingested nucleic acids
What percentage of uric acid elimination is accounted for by renal excretion?
70%
Where is most uric acid reabsorbed in the body?
Proximal tubules
What can happen to uric acid at high concentrations in the body?
Deposition in joints and tissues
What genetic disorder is caused by the complete deficiency of HGPRT?
Lesch-Nyhan syndrome
What is the main reason for monitoring uric acid concentration in patients on chemotherapy?
To monitor chemotherapy response
What is the primary reason for measuring uric acid?
To confirm diagnosis and monitor treatment of gout
In which condition is Lesch-Nyhan syndrome seen?
Males (X-linked genetic disorder)
What may cause elevated plasma uric acid concentration besides overproduction of uric acid?
All of the above
Who is very susceptible to the development of renal calculi and should have their uric acid concentration monitored?
Patients with gout
What is the main cause of pain and inflammation of the joints in gout?
Sodium urate precipitation
Where is uric acid reabsorbed in the body?
Kidneys
What is the predominant form of uric acid in acidic urine?
Uric acid crystals
Where does uric acid get transported from the liver to?
Blood
What is the typical plasma uric acid concentration in patients with gout?
> 6mg/dL
What happens to patients with gout in severe cases?
Tophi form causing deformities
Learn about the assessment and measurement of uric acid in the blood. Understand how uric acid is produced, and its relationship to purines, nucleic acids, and gout disease.
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