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Clinical Biochemistry Lecture 9: Enzyme Kinetics

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Clinical Biochemistry Lecture 9: Enzyme Kinetics

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Questions and Answers

What is the main concept of the Michaelis-Menten Theory?

The substrate induces conformational changes in the enzyme.

The enzyme and substrate have a rigid structure.

The enzyme and substrate fit together like a lock and key.

The enzyme combines with the substrate to form an enzyme-substrate complex. (correct)

According to the Lock and Key Theory, what is the relationship between the enzyme and substrate?

The substrate induces conformational changes in the enzyme.

The enzyme and substrate have a flexible structure.

The enzyme and substrate have no specific binding site.

The enzyme and substrate fit together like a lock and key. (correct)

What is the main limitation of the Lock and Key Theory?

It does not explain the flexibility of enzymes. (correct)

It does not explain the induced fit of enzymes.

It does not explain the role of enzymes in diagnosis.

It does not explain the binding of substrates to enzymes.

According to the Induced Fit Theory, what happens when the substrate binds to the enzyme?

The enzyme undergoes conformational changes. Signup and view all the answers

What is the analogy used to explain the Induced Fit Theory?

A glove on a hand. Signup and view all the answers

What is the clinical significance of enzymes in diagnosis?

They are used to diagnose diseases. Signup and view all the answers

What is the name of the theory that states that the three-dimensional structure of the active site of the enzyme is complementary to the substrate?

Fischer's Template Theory. Signup and view all the answers

Who is the proposer of the Induced Fit Theory?

Koshland. Signup and view all the answers

Study Notes

Enzyme-ll: Theories of Enzyme Action

Michaelis-Menten Theory

States that enzyme (E) combines with substrate (S) to form an enzyme-substrate (ES) complex
ES complex breaks down to enzyme and product (P)
Also known as the Enzyme-Substrate complex theory

Lock and Key Theory (Fischer's Template Theory)

States that the three-dimensional structure of the active site of the enzyme is complementary to the substrate
Enzyme and substrate fit each other like a lock and key
Implies a rigid structure for enzymes, which cannot explain their flexibility

Induced Fit Theory (Koshland's Theory)

Conformational changes occur at the active site of enzymes when combined with substrate
Substrate binds to a specific part of the enzyme, leading to secondary binding and conformational changes
Substrate induces conformational changes in the enzyme, similar to a glove fitting a hand
Enzyme's active site changes shape to accommodate the substrate

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Description

This quiz covers the concepts of enzyme kinetics, including the Michaelis-Menten Theory, and is based on the lecture notes of Dr. Naeem Salih Alzaidi.