Podcast
Questions and Answers
What form must fuel molecules take to enter the citric acid cycle?
What form must fuel molecules take to enter the citric acid cycle?
- A fatty acid
- Acetyl coenzyme A (correct)
- A dicarboxylic acid
- An amino acid
In the context of the citric acid cycle, what is the primary fate of acetate?
In the context of the citric acid cycle, what is the primary fate of acetate?
- Reduction to ethanol
- Conversion to pyruvate
- Incorporation into fatty acids
- Oxidation to $CO_2$ (correct)
Which of the following is the primary role of the citric acid cycle in aerobic metabolism?
Which of the following is the primary role of the citric acid cycle in aerobic metabolism?
- To directly produce large amounts of ATP
- To oxidize fuel molecules and produce reduced electron carriers. (correct)
- To synthesize amino acids and nucleotides
- To regenerate NADP+ for glycolysis.
Which of the following is a direct output of each turn of the citric acid cycle?
Which of the following is a direct output of each turn of the citric acid cycle?
What is the ultimate destination of NADH and $FADH_2$ produced during the citric acid cycle?
What is the ultimate destination of NADH and $FADH_2$ produced during the citric acid cycle?
Besides energy production, what other crucial role does the citric acid cycle play in the cell?
Besides energy production, what other crucial role does the citric acid cycle play in the cell?
Where within the cell do all the enzymatic reactions of the citric acid cycle take place?
Where within the cell do all the enzymatic reactions of the citric acid cycle take place?
How many molecules of $CO_2$ are produced per molecule of acetyl-CoA that enters the citric acid cycle?
How many molecules of $CO_2$ are produced per molecule of acetyl-CoA that enters the citric acid cycle?
What is the net production of NADH from one turn of the citric acid cycle?
What is the net production of NADH from one turn of the citric acid cycle?
Which of the following reactions in the citric acid cycle involves the direct consumption of water?
Which of the following reactions in the citric acid cycle involves the direct consumption of water?
Which enzyme catalyzes the condensation of acetyl-CoA with oxaloacetate to form citrate?
Which enzyme catalyzes the condensation of acetyl-CoA with oxaloacetate to form citrate?
What is the role of the enzyme aconitase in the citric acid cycle?
What is the role of the enzyme aconitase in the citric acid cycle?
Which enzyme catalyzes the first oxidation reaction in the citric acid cycle?
Which enzyme catalyzes the first oxidation reaction in the citric acid cycle?
Which of the following enzymatic reactions in the citric acid cycle is similar to the reaction converting pyruvate to acetyl-CoA?
Which of the following enzymatic reactions in the citric acid cycle is similar to the reaction converting pyruvate to acetyl-CoA?
The conversion of succinyl-CoA to succinate is coupled to which of the following?
The conversion of succinyl-CoA to succinate is coupled to which of the following?
Which enzyme catalyzes the oxidation of succinate to fumarate in the citric acid cycle?
Which enzyme catalyzes the oxidation of succinate to fumarate in the citric acid cycle?
What type of reaction is catalyzed by fumarase in the citric acid cycle?
What type of reaction is catalyzed by fumarase in the citric acid cycle?
Which enzyme catalyzes the final oxidation reaction in the citric acid cycle, regenerating oxaloacetate?
Which enzyme catalyzes the final oxidation reaction in the citric acid cycle, regenerating oxaloacetate?
Which of the following best describes the regulation of pyruvate dehydrogenase?
Which of the following best describes the regulation of pyruvate dehydrogenase?
What limits the activity of citrate synthase?
What limits the activity of citrate synthase?
How is isocitrate dehydrogenase regulated?
How is isocitrate dehydrogenase regulated?
By what mechanism is $\alpha$-ketoglutarate dehydrogenase regulated?
By what mechanism is $\alpha$-ketoglutarate dehydrogenase regulated?
Which of the following describes a key function of the pentose phosphate pathway?
Which of the following describes a key function of the pentose phosphate pathway?
Which electron carrier is primarily used to reduce substrates and functions synthetically, such as in steroid and fatty acid synthesis?
Which electron carrier is primarily used to reduce substrates and functions synthetically, such as in steroid and fatty acid synthesis?
Where does the pentose phosphate pathway take place within the cell?
Where does the pentose phosphate pathway take place within the cell?
What are the two main phases of the pentose phosphate pathway?
What are the two main phases of the pentose phosphate pathway?
Which of the following is directly generated in the oxidative phase of the pentose phosphate pathway?
Which of the following is directly generated in the oxidative phase of the pentose phosphate pathway?
The first committed step in the oxidative phase of the pentose phosphate pathway is catalyzed by which enzyme?
The first committed step in the oxidative phase of the pentose phosphate pathway is catalyzed by which enzyme?
What type of reaction is catalyzed by 6-phosphogluconate dehydrogenase in the pentose phosphate pathway?
What type of reaction is catalyzed by 6-phosphogluconate dehydrogenase in the pentose phosphate pathway?
What is the function of ribose phosphate isomerase in the pentose phosphate pathway?
What is the function of ribose phosphate isomerase in the pentose phosphate pathway?
What is the fate of ribulose 5-phosphate in cells that require more NADPH than pentose phosphates?
What is the fate of ribulose 5-phosphate in cells that require more NADPH than pentose phosphates?
Which of the following conversions occurs during the nonoxidative phase of the pentose phosphate pathway?
Which of the following conversions occurs during the nonoxidative phase of the pentose phosphate pathway?
Flashcards
Citric Acid Cycle
Citric Acid Cycle
A series of chemical reactions that extract energy from acetyl-CoA and produce electron carriers (NADH, FADH2) and GTP.
Citric Acid Cycle's Role
Citric Acid Cycle's Role
The final common pathway for the oxidation of fuel molecules, including amino acids, fatty acids, and carbohydrates.
Acetyl Coenzyme A
Acetyl Coenzyme A
Fuel molecules enter the cycle in this form.
Products per cycle
Products per cycle
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First step of TCA cycle
First step of TCA cycle
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Second step of TCA cycle
Second step of TCA cycle
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Third step of TCA cycle
Third step of TCA cycle
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Fourth step of TCA cycle
Fourth step of TCA cycle
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Fifth step of TCA cycle
Fifth step of TCA cycle
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Sixth step of TCA cycle
Sixth step of TCA cycle
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Seventh step of TCA cycle
Seventh step of TCA cycle
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Eighth step of TCA cycle
Eighth step of TCA cycle
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Pentose Phosphate Shunt
Pentose Phosphate Shunt
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Functions of PPP
Functions of PPP
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Subcellular Location of PPP
Subcellular Location of PPP
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Two Phases of PPP
Two Phases of PPP
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Oxidative Phase of PPP
Oxidative Phase of PPP
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Isomerization in PPP
Isomerization in PPP
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Overall Reaction of First Phase (PPP)
Overall Reaction of First Phase (PPP)
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Nonoxidative Phase of PPP
Nonoxidative Phase of PPP
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