Citric Acid Cycle and Biosynthesis
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Questions and Answers

Which compound is a precursor of several amino acids?

  • Oxaloacetate
  • α-ketoglutarate (correct)
  • Succinyl-CoA
  • Phosphoenolpyruvate

What is corrected by the addition of CO2 in the citric acid cycle?

  • Insufficient α-ketoglutarate
  • Lack of phosphoenolpyruvate
  • Shortage of oxaloacetate (correct)
  • Excess of succinyl-CoA

Which compound provides the raw material for fatty acid biosynthesis?

  • Isocitrate
  • Succinate
  • Malate
  • Acetate (correct)

Which pathway plays two major roles in the cell: oxidation of organic compounds and biosynthesis of key metabolites?

<p>Citric Acid Cycle (C)</p> Signup and view all the answers

What are drawn off from the glycolytic pathway for biosynthetic needs?

<p>Certain intermediates (A)</p> Signup and view all the answers

Flashcards

α-ketoglutarate: Precursor of amino acids

A molecule that acts as a starting point for the synthesis of several amino acids. It plays a crucial role in both metabolism and biosynthesis.

How is the citric acid cycle regulated?

The citric acid cycle compensates for the depletion of oxaloacetate by adding CO2 to replenish its levels.

What is the raw material for fatty acid biosynthesis?

Acetate is a simple compound that serves as the primary building block for the construction of fatty acids. It's like the individual bricks that build the structures of fats.

What are the roles of the citric acid cycle?

The citric acid cycle plays a vital role in both the breakdown of organic compounds (energy production) and the synthesis of essential molecules needed for cell functioning.

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What are drawn off from the glycolytic pathway?

The glycolytic pathway, responsible for breaking down glucose, also provides intermediates that are required for other metabolic pathways. It's a vital source of building blocks.

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Study Notes

Amino Acid Precursor

  • Alpha-ketoglutarate serves as a precursor for several amino acids, including glutamate, which can further be converted into other amino acids.

Citric Acid Cycle Correction

  • The addition of CO2 corrects the formation of oxaloacetate from malate, enhancing the citric acid cycle's efficiency and ensuring proper metabolic flow.

Fatty Acid Biosynthesis Material

  • Acetyl-CoA is the raw material needed for the biosynthesis of fatty acids, playing a crucial role in energy storage and membrane formation.

Dual-Role Pathway

  • The Pentose Phosphate Pathway has two major functions: it oxidizes glucose to generate NADPH for reductive biosynthesis and produces ribose-5-phosphate for nucleotide synthesis.

Glycolytic Pathway Derivatives

  • Intermediates from the glycolytic pathway, such as pyruvate and glyceraldehyde-3-phosphate, are drawn off for biosynthetic processes, supporting the synthesis of amino acids, nucleotides, and lipids.

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Description

Test your knowledge about the role of the citric acid cycle in biosynthesis. This quiz covers the key organic compounds involved and their importance in the production of new cell material.

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