Cinacalcet/Sensipar Flashcards

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Questions and Answers

What is the brand name of Cinacalcet?

  • Hypocalcemia
  • PTH
  • Sensipar (correct)
  • Calcimimetics

What is the generic name of Sensipar?

  • Parathyroid hormone
  • Calcium
  • Calcimimetics
  • Cinacalcet (correct)

What class of drug is Cinacalcet/Sensipar?

Calcimimetics

What is the mechanism of action (MOA) of Cinacalcet/Sensipar?

<p>Increases parathyroid gland chief cell Ca sensing receptor sensitivity to extracellular calcium decreasing PTH secretion</p> Signup and view all the answers

What are the indications for using Cinacalcet/Sensipar?

<p>Secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, hypercalcemia with primary hyperparathyroidism and parathyroid carcinoma.</p> Signup and view all the answers

What is a contraindication for Cinacalcet/Sensipar?

<p>Hypocalcemia</p> Signup and view all the answers

What are potential adverse reactions of Cinacalcet/Sensipar?

<p>Hypocalcemia, hypoparathyroidism, QT prolongation, ventricular arrhythmias</p> Signup and view all the answers

What precaution should be considered when using Cinacalcet/Sensipar?

<p>QT syndrome or QT prolongation</p> Signup and view all the answers

What is a noted drug interaction with Cinacalcet/Sensipar?

<p>Eliglustat - increased levels</p> Signup and view all the answers

The common doses for Cinacalcet/Sensipar are ______ mg.

<p>30, 60, 90</p> Signup and view all the answers

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Study Notes

Cinacalcet/Sensipar Overview

  • Cinacalcet is marketed under the brand name Sensipar.
  • It belongs to the drug class of calcimimetics.

Mechanism of Action (MOA)

  • Enhances sensitivity of parathyroid gland chief cell calcium-sensing receptors.
  • Results in decreased secretion of parathyroid hormone (PTH).

Indications for Use

  • Treats secondary hyperparathyroidism in patients with chronic kidney disease on dialysis.
  • Used for hypercalcemia associated with primary hyperparathyroidism and for parathyroid carcinoma.

Contraindications

  • Should not be used in patients with hypocalcemia.

Adverse Reactions

  • Common adverse effects include hypocalcemia and hypoparathyroidism.
  • May lead to QT prolongation and increase risk of ventricular arrhythmias.

Precautions

  • Caution is advised in patients with QT syndrome or existing QT prolongation.

Drug Interactions

  • Has known interactions with eliglustat, which can lead to increased serum levels.

Dosage and Administration

  • Available in dosages of 30 mg, 60 mg, and 90 mg for administration.

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