10 Questions
Cidofovir contains a phosphate group instead of a phosphonate group.
False
The presence of a phosphate group in Cidofovir makes it more stable.
False
Cidofovir is degraded quickly in the body due to the presence of phosphatases.
False
The stability of Cidofovir is Enhanced due to the presence of a phosphonate group.
True
Cidofovir remains active in the body for a shorter period due to the presence of phosphatases.
False
The (R)(-)-enantiomer of Indometacin displays anti-inflammatory activity.
False
The N-p-chlorobenzoyl group of Indometacin orients towards the 2-methyl group in its preferred confirmation.
False
The indole ring and the chlorophenyl ring are coplanar in the preferred confirmation of Indometacin.
False
The presence of the 2-methyl group in Indometacin does not affect the orientation of the chlorophenyl ring.
False
The anti-inflammatory activity of Indometacin is independent of its molecular chirality.
False
Study Notes
Cidofovir Characteristics
- Cidofovir has a phosphonate group instead of a phosphate group, which increases its stability.
- The phosphonate group makes cidofovir resistant to degradation by phosphatases.
- This modification allows cidofovir to remain active in the body for a longer period.
Chirality of Indometacin
- Chirality in the Indometacin molecule is crucial for its anti-inflammatory activity
- Only the (S)(+)-enantiomer displays anti-inflammatory activity
Confirmation of Indometacin
- The confirmation of Indometacin plays a crucial role in its anti-inflammatory actions
- The preferred confirmation of the N-p-chlorobenzoyl group is characterized by:
- The chlorophenyl ring oriented away from the 2-methyl group
- The chlorophenyl ring is cis to the methoxyphenyl ring of the indole nucleus
- The chlorophenyl ring is non-coplanar with the indole ring due to steric hindrance caused by:
- The 2-methyl group
- The hydrogen atom at the 7-position
Cidofovir's unique structure and benefits over other antiviral drugs. Learn how its phosphonate group enhances its stability and duration of activity.
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