Chronic Toxicity Testing in Animals
18 Questions
2 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is a key ethical consideration in acute lethality tests?

  • Species extrapolation
  • Inflicting pain and suffering (correct)
  • Species selection
  • Dose selection
  • In acute toxicity testing, what aspect helps in balancing benefits and risks?

  • Post-test care
  • Level of harm
  • Transparency and accountability
  • Justifying the test (correct)
  • What is a critical factor to consider when determining the level of harm in acute toxicity testing?

  • Psychological impact
  • Dose selection (correct)
  • Public perception
  • Alternatives vs. benefits
  • Which factor in acute toxicity testing emphasizes the need for alternatives to animal testing?

    <p>Alternatives vs. benefits</p> Signup and view all the answers

    What should be carefully considered to minimize psychological impacts in acute toxicity tests?

    <p>Species selection</p> Signup and view all the answers

    In acute lethality tests, why is transparency and accountability important?

    <p>Public perception</p> Signup and view all the answers

    What are some parameters monitored during chronic toxicity testing?

    <p>Food and water consumption</p> Signup and view all the answers

    Which of the following is a common route of administration in toxicity testing?

    <p>Oral ingestion</p> Signup and view all the answers

    What is the purpose of monitoring hematological and biochemical parameters in toxicity testing?

    <p>To identify physiological changes indicative of toxicity</p> Signup and view all the answers

    Which ethical principle advocates for reducing the number of animals used in toxicology experiments?

    <p>Replacement, Reduction, Refinement</p> Signup and view all the answers

    Why is it important to obtain ethical clearance before conducting chronic toxicity tests?

    <p>To meet regulatory requirements and avoid legal issues</p> Signup and view all the answers

    How do ethical considerations promote humane treatment in chronic toxicity testing?

    <p>By promoting the use of alternative methods and minimizing animal distress</p> Signup and view all the answers

    Which principle promotes the ethical treatment of animals in research?

    <p>Replacement, Reduction, and Refinement</p> Signup and view all the answers

    What is the purpose of the Draize test?

    <p>Assessing eye irritancy</p> Signup and view all the answers

    Why is the New Zealand White rabbit preferred for the Draize test?

    <p>Ease of handling and low cost</p> Signup and view all the answers

    What is a key aspect of Replacement in the 3Rs principle?

    <p>Minimizing animal testing by using alternatives</p> Signup and view all the answers

    In the Draize test, what body parts are observed for effects after applying the test substance?

    <p>Cornea, conjunctiva, and iris</p> Signup and view all the answers

    What is the focus of Refinement in the 3Rs principle?

    <p>Improving the welfare of animals involved</p> Signup and view all the answers

    Study Notes

    Acute Lethality Tests

    • Key ethical consideration: animal welfare and minimizing harm
    • Balancing benefits and risks: consideration of animal welfare and scientific objectives
    • Critical factor in determining harm: severity and duration of adverse effects

    Alternatives to Animal Testing

    • Emphasis on alternatives: reduction of animal suffering and promotion of humane treatment

    Psychological Impacts

    • Minimizing psychological impacts: careful consideration of animal welfare and stress minimization

    Transparency and Accountability

    • Importance of transparency and accountability: ensuring responsible and ethical conduct of tests

    Chronic Toxicity Testing

    • Monitored parameters: physiological, biochemical, and histopathological changes
    • Common route of administration: oral, dermal, or inhalation

    Hematological and Biochemical Parameters

    • Purpose of monitoring: detection of adverse effects and organ damage

    Ethical Principles

    • Reducing the number of animals used: 3Rs principle, particularly Replacement
    • Importance of ethical clearance: ensuring compliance with animal welfare regulations
    • Promoting humane treatment: ethical considerations and Refinement principle
    • Focus of Refinement: minimizing stress and discomfort in animals

    Draize Test

    • Purpose: evaluation of ocular and dermal irritancy of chemicals
    • Preferred animal model: New Zealand White rabbit
    • Observed body parts: eyes and skin
    • Key aspect of Replacement: development of alternative methods to animal testing

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Explore the procedures and parameters involved in chronic toxicity testing in animals, including administration methods and monitoring techniques. Learn about the ethical considerations surrounding these tests.

    More Like This

    Toxicity Testing in Modern Society
    12 questions
    1er partie biotech
    69 questions

    1er partie biotech

    WarmSelenium7607 avatar
    WarmSelenium7607
    Toxicity Testing Overview
    10 questions

    Toxicity Testing Overview

    MatchlessLearning3493 avatar
    MatchlessLearning3493
    Use Quizgecko on...
    Browser
    Browser