أسئلة الخامسة باثولوجي RESP (قبل التعديل)

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Questions and Answers

Which type of COPD is characterized by permanent dilation of the air spaces distal to the terminal bronchioles?

  • Bronchial asthma
  • Emphysema (correct)
  • Chronic bronchitis
  • Bronchiectasis

What is a significant pathological change in the bronchial mucosa associated with COPD?

  • Increased ciliated cell count
  • Thickening and opacity of the mucosa (correct)
  • Thinning of the mucosal lining
  • Decreased mucous gland activity

Chronic bronchitis in COPD is defined as a productive cough lasting for how long?

  • 3 months (correct)
  • 6 months
  • 12 months
  • 1 month

Which factor is NOT commonly listed as a cause of COPD?

<p>Viral infections (D)</p> Signup and view all the answers

In which type of emphysema are the respiratory bronchioles primarily affected?

<p>Centrilobular emphysema (B)</p> Signup and view all the answers

What is a common complication associated with COPD?

<p>Chronic hypoxaemia (B)</p> Signup and view all the answers

Which demographic is primarily affected by emphysema?

<p>Middle-aged men aged 40-60 (C)</p> Signup and view all the answers

What type of cell change is observed in the bronchial mucosa of COPD patients?

<p>Decreased number of ciliated cells (A)</p> Signup and view all the answers

What is primarily weakened due to the elastase-antielastase imbalance in smokers?

<p>Walls of air spaces (D)</p> Signup and view all the answers

Which theory of cigarette smoke damage explains the direct injury to airspace walls?

<p>Direct Damage Theory (C)</p> Signup and view all the answers

Which characteristic describes centriacinar emphysema?

<p>Upper zones of lung lobes first affected (D)</p> Signup and view all the answers

What physical change occurs in the chest due to panacinar emphysema?

<p>Exaggerated inspiration position (B)</p> Signup and view all the answers

What happens to mucus secretion in chronic bronchitis as a result of smoking?

<p>Increases, leading to mucus plugs (B)</p> Signup and view all the answers

What is a common feature of lungs affected by panacinar emphysema?

<p>Pale and dry appearance (B)</p> Signup and view all the answers

What causes the intraluminal pressure to increase during expiration in smokers?

<p>Trapped air due to mucus plugs (A)</p> Signup and view all the answers

What physical characteristic describes bullae in emphysematous lungs?

<p>Semitranslucent with paper-thinned walls (B)</p> Signup and view all the answers

What type of emphysema is characterized by the presence of dilated respiratory bronchioles while preserving the alveolar ducts and alveoli?

<p>Centrilobular emphysema (A)</p> Signup and view all the answers

Which of the following conditions is a complication associated with Chronic Obstructive Pulmonary Disease (COPD)?

<p>Spontaneous pneumothorax (B)</p> Signup and view all the answers

What is the main cause of bronchiectasis as described in the content?

<p>Chronic pyogenic infection (A)</p> Signup and view all the answers

Which statement correctly describes the nature of interstitial emphysema?

<p>Escape of alveolar air into the interstitial tissue (B)</p> Signup and view all the answers

What structural change occurs in the bronchi during bronchiectasis?

<p>Dilation of medium and smaller sized bronchi (C)</p> Signup and view all the answers

Which factor can contribute to the pushing forces causing bronchial dilatation?

<p>Bronchial obstruction (A)</p> Signup and view all the answers

What type of hyperinflation is characterized by an increase in lung volume due to compensatory mechanisms?

<p>Compensatory hyperinflation (C)</p> Signup and view all the answers

Which feature is NOT typically seen in the pathology of bronchiectasis?

<p>Excessive airflow obstruction (C)</p> Signup and view all the answers

Which aspect is NOT a characteristic of chronic bronchitis in COPD?

<p>Acute airway obstruction (A)</p> Signup and view all the answers

What is a distinguishing feature of centriacinar emphysema compared to panacinar emphysema?

<p>Primarily affects respiratory bronchioles (C)</p> Signup and view all the answers

How does chronic inflammation of the upper respiratory tract contribute to COPD?

<p>It causes increased mucus secretion (B)</p> Signup and view all the answers

What is a common demographic feature associated with bronchiectasis as noted in the context of COPD?

<p>Frequently occurs in the elderly population (C)</p> Signup and view all the answers

Which of the following is NOT a noted cause of COPD?

<p>Genetic predisposition to allergic reactions (B)</p> Signup and view all the answers

What is the primary pathological change observed in the bronchial mucosa of COPD patients?

<p>Squamous metaplasia (D)</p> Signup and view all the answers

What complication of COPD is directly linked to chronic hypoxaemia?

<p>Pulmonary hypertension (C)</p> Signup and view all the answers

In which scenario would one observe the respiratory bronchioles and alveolar ducts being primarily affected?

<p>Panacinar emphysema (A)</p> Signup and view all the answers

What is the primary pathological change observed in the walls of bronchi during bronchiectasis?

<p>Chronic suppurative inflammation (A)</p> Signup and view all the answers

What mechanism contributes to pulmonary hypertension in patients with chronic bronchitis?

<p>Increased pressure from airway obstruction (B)</p> Signup and view all the answers

What happens to the alveolar septa in advanced stages of panacinar emphysema?

<p>They rupture and lead to airspace enlargement. (D)</p> Signup and view all the answers

Which type of emphysema is associated with the escape of alveolar air into the interstitial tissue?

<p>Interstitial emphysema (A)</p> Signup and view all the answers

What type of hyperinflation occurs in response to lung disease and results in increased lung volume without the context of obstructive forces?

<p>Compensatory hyperinflation (B)</p> Signup and view all the answers

What structural feature characterizes the bronchi in bronchiectasis?

<p>Dilation with pus accumulation (C)</p> Signup and view all the answers

Which demographic is more likely to develop bronchiectasis according to the content provided?

<p>Males before the age of 20 (C)</p> Signup and view all the answers

What type of forces are involved in the dilation of bronchi as seen in bronchiectasis?

<p>Pushing forces from inside and pulling forces from outside (A)</p> Signup and view all the answers

Which theory explains the role of neutrophils and macrophages in causing damage to lung tissue through elastase release?

<p>Chronic Bronchitis Theory (B)</p> Signup and view all the answers

What is a characteristic feature of the lungs affected by centriacinar emphysema?

<p>Enlarged air spaces occur predominantly in upper zones (A)</p> Signup and view all the answers

How does cigarette smoking contribute to chronic bronchitis according to the Chronic Bronchitis Theory?

<p>By recruiting inflammatory cells and increasing mucus secretion (C)</p> Signup and view all the answers

What anatomical change is associated with panacinar emphysema as noted in the detailed description?

<p>Barrel-shaped chest and voluminous lungs (C)</p> Signup and view all the answers

What happens to the chest wall in cases of panacinar emphysema during inspiration?

<p>Holds a fixed position with increased diameter (A)</p> Signup and view all the answers

What is the primary role of elastase and antielastase in the context of smoking-related lung damage?

<p>Elastase leads to tissue destruction while antielastase inhibits elastase action (D)</p> Signup and view all the answers

In the pathogenesis of smoking-related lung disease, which process is associated with the direct injury to air space walls?

<p>Direct Damage Theory (A)</p> Signup and view all the answers

What is described as a bulla in the context of emphysematous lungs?

<p>An emphysematous space greater than 1 cm diameter (D)</p> Signup and view all the answers

Flashcards

COPD Definition

A group of lung diseases causing obstructed airflow. This obstruction can happen at various points in the lungs.

COPD Types

COPD can be categorized into chronic bronchitis, bronchial asthma, emphysema, and bronchiectasis.

Chronic Bronchitis Definition

Persistent coughing with phlegm, lasting at least 3 months of the year, for 2 years.

Emphysema Definition

Permanent damage to air sacs in the lungs, leading to air trapping.

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Emphysema Cause

Likely due to chronic irritation in the airways, including smoking and pollution.

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Centrilobular Emphysema

Damage primarily to the central parts of the lung's air sacs.

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Panacinar Emphysema

Damage to the entire air sac (acinar) unit.

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COPD Complications

COPD can lead to low blood oxygen, high blood pressure in the lungs, and eventually heart failure.

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Elastase-Antielastase Imbalance

Smoking increases elastase (breaks down lung tissue) and decreases antielastase. This imbalance damages lung air spaces.

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Direct Damage Theory

Toxic substances in cigarette smoke directly harm the walls of the air spaces in the lungs.

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Chronic Bronchitis Theory

Smoking triggers neutrophils, leading to more elastase and mucus production. This mucus can obstruct the airways.

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Centriacinar Emphysema

Lung damage starts in the upper parts of the lobes, leading to enlarged air spaces.

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Barrel Chest

A chest that is permanently enlarged, with a wider front-to-back dimension than side-to-side.

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Bullae

Large, air-filled sacs (more than 1 cm) in the lungs, resulting from loss of lung elasticity.

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α1 antitrypsin deficiency

Inherited deficiency of a protein that protects lung tissue. It makes a person more susceptible to COPD.

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What is COPD?

COPD stands for Chronic Obstructive Pulmonary Disease and is a group of lung diseases that cause airflow obstruction. It's a long-term condition that worsens over time.

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Types of Emphysema

There are two main types of emphysema: Centrilobular and Panacinar. Centrilobular emphysema affects the central parts of the air sacs, while Panacinar emphysema affects the entire air sac unit.

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Chronic Bronchitis

A condition where the airways in the lungs are inflamed and produce excess mucus leading to persistent coughing with phlegm, lasting at least 3 months per year for 2 years.

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Bronchiectasis

A condition where the airways in the lungs become permanently enlarged and damaged, making it difficult to clear mucus and leading to frequent infections.

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Obstructive Hyperinflation

A condition where the lungs become overinflated due to air trapping, making it difficult to exhale completely.

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What are the main types of COPD?

The main types of COPD are chronic bronchitis, emphysema, and bronchiectasis.

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Emphysema

Emphysema is a lung condition where the air sacs in the lungs are damaged, leading to air trapping and making it hard to exhale.

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What happens in emphysema?

In emphysema, the walls of the tiny air sacs in the lungs get damaged, leading to larger, less elastic air sacs that trap air.

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Why is COPD more common in smokers?

Smoking causes chronic irritation in the airways, leading to inflammation and damage to the air sacs, making COPD more likely.

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What are some complications of COPD?

Complications of COPD can include low blood oxygen, high blood pressure in the lungs, and heart failure.

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What is α1 antitrypsin deficiency?

An inherited condition where the body lacks a protein that protects lung tissue, making individuals more susceptible to COPD.

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COPD: What is it?

COPD stands for Chronic Obstructive Pulmonary Disease. It's a group of lung diseases that cause airflow obstruction, making it hard to breathe.

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Emphysema: Damage to Air Sacs.

Emphysema is a type of COPD where the tiny air sacs in the lungs become damaged, leading to air trapping and difficulty exhaling.

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COPD: Causes

COPD is often caused by long-term exposure to irritants like cigarette smoke, air pollution, and dust.

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Study Notes

Chronic Obstructive Pulmonary Disease (COPD)

  • COPD is a group of lung diseases characterized by resistance to airflow due to obstruction at any level.
  • Types include chronic bronchitis, emphysema, and bronchiectasis.

Chronic Bronchitis

  • Definition: Persistent productive cough (coughing up sputum) for at least 3 consecutive months in at least 2 consecutive years.
  • Causes: Cigarette smoking, atmospheric pollution, chronic inflammation of upper respiratory tract (tonsils, mouth).
  • Pathology: Bronchial mucosa thick, opaque, and covered by excess mucus. Mucous gland hyperplasia and decreased number of ciliated cells, squamous metaplasia, and chronic inflammatory cell infiltrations.
  • Complications: Centrilobular emphysema, bronchopneumonia, bronchogenic carcinoma, chronic hypoxemia (leading to pulmonary hypertension and cardiac failure).

Emphysema

  • Definition: Permanent dilatation of air spaces distal to terminal bronchioles with damage to their walls (respiratory acinus).
  • Incidence: Commonest chronic lung disease, more common in males aged 40-60 years.
  • Two types:
    • Centrilobular emphysema: Affects the upper lung zones first.
    • Panacinar emphysema: Affects the lower lung zones first.

Bronchiectasis

  • Definition: Permanent (irreversible) dilatation of medium-sized bronchi and bronchioles.
  • Cause: Chronic suppurative inflammation in the bronchial walls and surrounding lung tissue.
  • Clinical presentation: Frequent before age 20, males more than females, can occur in adults.
  • Pathogenesis: Weak bronchial walls due to chronic pyogenic infection; forces for dilatation include bronchial obstruction (pushing forces from inside)and external pulling forces.

COPD Pathological Findings (Microscopic/Gross)

  • Centrilobular Emphysema: Dilated respiratory bronchioles with normal alveolar ducts and alveoli.
  • Panacinar Emphysema: Fewer, enlarged alveoli, distorted in shape, with rupture of interalveolar septa; reduced interalveolar capillaries due to air dilation.
  • Bronchiectasis: Affected bronchi displaying chronic inflammation, shedded epithelial cells, inflammatory cells, RBCs, extensive mucosal ulceration, and infiltration of the wall with inflammatory cells.
  • Lungs: Areas of lung collapse, fibrosis, and compensatory emphysema.

COPD Complications

  • Respiratory System: Chronic bronchitis, interstitial emphysema, spontaneous pneumothorax, respiratory failure.
  • Cardiovascular System: Pulmonary hypertension, right-sided heart failure.

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