Podcast
Questions and Answers
Which cytokine down-regulates the responses of activated macrophages in the inflammatory response?
Which cytokine down-regulates the responses of activated macrophages in the inflammatory response?
What is a rare inherited disease that leads to severe colitis in infancy due to mutated IL-10 receptors?
What is a rare inherited disease that leads to severe colitis in infancy due to mutated IL-10 receptors?
Which cytokine is also a mediator of fibrosis in tissue repair after inflammation?
Which cytokine is also a mediator of fibrosis in tissue repair after inflammation?
What type of infiltrate characterizes chronic inflammation, in contrast with acute inflammation?
What type of infiltrate characterizes chronic inflammation, in contrast with acute inflammation?
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Which intracellular proteins inhibit pro-inflammatory signals triggered by receptors recognizing microbes and cytokines?
Which intracellular proteins inhibit pro-inflammatory signals triggered by receptors recognizing microbes and cytokines?
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Study Notes
Regulation of Inflammation
- IL-10 down-regulates the responses of activated macrophages in the inflammatory response.
Genetic Disorders and Inflammation
- IL-10 receptor deficiency is a rare inherited disease that leads to severe colitis in infancy.
Cytokines in Tissue Repair
- TGF-β is a mediator of fibrosis in tissue repair after inflammation.
Characteristics of Inflammation
- Chronic inflammation is characterized by a mononuclear infiltrate, in contrast with acute inflammation.
Negative Regulation of Inflammation
- Intracellular proteins, such as SOCS (Suppressor of Cytokine Signaling), inhibit pro-inflammatory signals triggered by receptors recognizing microbes and cytokines.
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Description
Test your knowledge of the mechanisms that counteract and regulate chronic inflammation, including the role of lipoxins, complement regulatory proteins, and cytokine IL-10.
