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Questions and Answers
Which cytokine down-regulates the responses of activated macrophages in the inflammatory response?
What is a rare inherited disease that leads to severe colitis in infancy due to mutated IL-10 receptors?
Which cytokine is also a mediator of fibrosis in tissue repair after inflammation?
What type of infiltrate characterizes chronic inflammation, in contrast with acute inflammation?
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Which intracellular proteins inhibit pro-inflammatory signals triggered by receptors recognizing microbes and cytokines?
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Study Notes
Regulation of Inflammation
- IL-10 down-regulates the responses of activated macrophages in the inflammatory response.
Genetic Disorders and Inflammation
- IL-10 receptor deficiency is a rare inherited disease that leads to severe colitis in infancy.
Cytokines in Tissue Repair
- TGF-β is a mediator of fibrosis in tissue repair after inflammation.
Characteristics of Inflammation
- Chronic inflammation is characterized by a mononuclear infiltrate, in contrast with acute inflammation.
Negative Regulation of Inflammation
- Intracellular proteins, such as SOCS (Suppressor of Cytokine Signaling), inhibit pro-inflammatory signals triggered by receptors recognizing microbes and cytokines.
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Description
Test your knowledge of the mechanisms that counteract and regulate chronic inflammation, including the role of lipoxins, complement regulatory proteins, and cytokine IL-10.
