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Chromosome Structure and Telomeres

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Questions and Answers

What does the telomere region of a chromosome contain?

Adenine-thymine rich base pairs

A single-stranded DNA molecule

5'-TTAGGG-3' sequence (correct)

5'-GGATCC-3' sequence

The centromere region of a chromosome is responsible for what function?

Extension of the chromosome

Replication of the chromosome

Protection of the chromosome ends

Segregation of the replicated chromosome during mitosis and meiosis (correct)

What is the physical structure of a chromosome composed of?

Single-stranded DNA molecules

Single-stranded RNA molecules

Double-stranded RNA molecules

Double-stranded DNA molecules (correct)

What are the two arms of a chromosome?

A long arm (q) and a short arm (p) Signup and view all the answers

What is the first step in the replication of a chromosome?

Identification of the ori-site Signup and view all the answers

What is the Okazaki fragment part of?

The lagging strand Signup and view all the answers

What phenomenon results in the shortening of the lagging strand during chromosome replication?

The inability of enzymes to fully replicate the end of a chromosome Signup and view all the answers

What occurs after the DNA is unwound during chromosome replication?

The replication fork is formed Signup and view all the answers

What is needed for the synthesis of Okazaki fragments on the lagging strand?

RNA primers attaching ahead on the lagging strand Signup and view all the answers

What does the state of cellular senescence result in?

Irreversible growth arrest Signup and view all the answers

What can trigger cellular senescence?

Telomeric shortening Signup and view all the answers

What does the Hayflick limit refer to?

The maximum replicative capacity of cells Signup and view all the answers

What happens when cells reach the Hayflick limit?

Cells can no longer divide Signup and view all the answers

What is contact inhibition in the context of cellular density?

Cells become more sensitive to inhibition by neighboring cells Signup and view all the answers

Chromosome Structure and Telomeres

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Podcast

Questions and Answers

What does the telomere region of a chromosome contain?

The centromere region of a chromosome is responsible for what function?

What is the physical structure of a chromosome composed of?

What are the two arms of a chromosome?

What is the first step in the replication of a chromosome?

What is the Okazaki fragment part of?

What phenomenon results in the shortening of the lagging strand during chromosome replication?

What occurs after the DNA is unwound during chromosome replication?

What is needed for the synthesis of Okazaki fragments on the lagging strand?

What does the state of cellular senescence result in?

What can trigger cellular senescence?

What does the Hayflick limit refer to?

What happens when cells reach the Hayflick limit?

What is contact inhibition in the context of cellular density?

What contributes to cellular senescence during DNA replication?

What can cause aging and senescence apart from telomeric shortening?

Which factor is not mentioned as a contributor to cellular senescence?

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