Chromatin Remodeling and Epigenetic Modifications Quiz

Chromatin remodeling is the process of altering the structure of chromatin, the complex of DNA and protein that makes up chromosomes.

When chromatin is open, the DNA is more accessible to transcription factors, and gene transcription is more likely to occur.

Chromatin remodeling complexes are large protein complexes that can slide nucleosomes along the DNA or alter the histone-DNA interactions.

<p>Histone methylation is a type of post-translational modification (PTM) of histones, in which a methyl group is added to a histone protein.</p> Signup and view all the answers

<p>Histone methylation can occur on lysine, arginine, or histidine residues of histone tails.</p> Signup and view all the answers

<p>In general, histone methylation is associated with repression of gene transcription.</p> Signup and view all the answers

<p>Chromatin remodeling complexes can open up chromatin and allow transcription factors to access the DNA, thereby regulating gene expression.</p> Signup and view all the answers

<p>Histone acetylation is a post-translational modification of histones where an acetyl group is added to a lysine residue of a histone protein.</p> Signup and view all the answers

<p>Histone acetylation is generally associated with the activation of gene transcription.</p> Signup and view all the answers

<p>Chromatin remodeling, methylation, and acetylation work together to regulate gene expression, where chromatin remodeling can open up chromatin, while histone methylation and acetylation can determine the activation or repression of gene transcription.</p> Signup and view all the answers

<p>Chromatin remodeling can open up chromatin, allowing transcription factors to access the DNA.</p> Signup and view all the answers

<p>Dysregulation of these processes can lead to various diseases, including cancer, due to aberrant histone methylation patterns that can silence tumor suppressor genes and activate oncogenes in cancer cells.</p> Signup and view all the answers

<p>Histone acetylation generally has the opposite effect of histone methylation and is associated with the activation of gene transcription.</p> Signup and view all the answers

<p>Aberrant histone methylation patterns in cancer cells can lead to the silencing of tumor suppressor genes and the activation of oncogenes.</p> Signup and view all the answers

<p>Histone methylation and acetylation can determine whether or not transcription factors are able to activate or repress gene transcription.</p> Signup and view all the answers