10 Questions
Which subunit of RNA polymerase II is responsible for trapping the template DNA strand and transcript during formation of the transcribing complex?
Clamp domain
What ion participates in the catalysis of phosphodiester bond formation during RNA transcription by RNA polymerase II?
Mg2+
Which region of RNA polymerase II is thought to bend and straighten as the polymerase translocates one base down the template strand?
Bridge α helix
Which of the following is NOT a conserved element that highly regulates RNA polymerase II-transcribed genes?
Chromatin remodeling proteins
During RNA transcription, what does the bridge α helix in RNA polymerase II extend across?
The cleft in the polymerase
Which element helps couple clamp closure in RNA polymerase II to the presence of RNA during transcription?
Clamp domain
What are the core regulatory elements that highly regulate RNA polymerase II-transcribed genes known as?
Core promoter sequences
Which type of promoters are shown in the Core promoter elements of non-CpG island promoters in metazoans?
Non-CpG island promoters
What site(s) do transcriptional activators bind to in relation to the promoter?
Proximal binding sites
What element forces the template DNA to bend before exiting the polymerase during RNA transcription?
Wall domain
Test your knowledge on how chromatin condensation affects gene transcription, blocking RNA polymerases and general transcription factors from interacting with gene promoters. Learn about the differences between prokaryotic and eukaryotic DNA and the role of chromatin in gene activation. Explore the concepts of chromatin-mediated regulation and heterochromatin in epigenetic regulation.
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