Questions and Answers
Which type of stem cells do hondrosarcomas arise from?
Mesenchymal stem cells
What is a characteristic radiographic finding in early chondrosarcomas?
Garrington sign
Which malignancy of bone arises from marrow mesenchymal stem cells with reciprocal translocation of chromosomes 11 and 22?
Ewing sarcoma
What clinical presentation can lead to confusion between Ewing sarcoma and osteomyelitis?
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How does Ewing sarcoma typically appear radiographically?
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What distinguishes a true chondrosarcoma from other types of sarcomas?
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Which radiographic sign is characteristic of early chondrosarcomas?
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What is the clinical manifestation of Ewing sarcoma that can lead to confusion with osteomyelitis?
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What differentiates Ewing sarcoma from true chondrosarcomas radiographically?
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What is a characteristic feature of hondrosarcomas based on their origin?
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Study Notes
Chondrosarcomas
- Arise from mesenchymal stem cells
- Undergo partial differentiation to form chondroblastic differentiation or cartilage
- A true chondrosarcoma cannot demonstrate bone
- Radiographically, early chondrosarcomas show a widening of the periodontal ligament space (Garrington sign)
Ewing Sarcoma
- A very aggressive and destructive malignancy of bone
- Arises from marrow mesenchymal stem cells
- Characterized by reciprocal translocation of chromosomes 11 and 22
- Clinically manifests as a rapidly expanding lesion
- Accompanied by mobile teeth, fever, and bone necrosis
- Can be confused clinically with osteomyelitis
- Radiographically produces an ill-defined destructive lesion with focal areas of residual bone
- Residual bone resembles sequestra
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